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| 1 | Relationship between vascular endothelium and periodontal disease in atherosclerotic lesions: Review article显示文摘Inflammation and endothelial dysfunction are linked to the pathogenesis of atherosclerotic disease. Recent studies suggest that periodontal infection and the ensuing increase in the levels of inflammatory markers may be associated with myocardial infarction, peripheral vascular disease and cerebrovascular disease. The present article aimed at reviewing contemporary data on the pathophysiology of vascular endothelium and its association with periodontitis in the scenario of cardiovascular disease. | Marco Aurélio Lumertz Saffi Mariana Vargas Furtado Carisi Anne Polanczyk Márlon Munhoz Montenegro Ingrid Webb Josephson Ribeiro Cassio Kampits Alex Nogueira Haas Cassiano Kuchenbecker Rosing Eneida Rejane Rabelo-Silva | 2015 | World Journal of Cardiology2015，7，1： | 9 |
| 2 | Proton nuclear magnetic resonance-based metabonomic models for non-invasive diagnosis of liver fibrosis in chronic hepatitis C:Optimizing the classification of intermediate fibrosis显示文摘AIM To develop metabonomic models(MMs), using 1 H nuclear magnetic resonance(NMR) spectra of serum, to predict significant liver fibrosis(SF: Metavir ≥ F2), advanced liver fibrosis(AF: METAVIR ≥ F3) and cirrhosis(C: METAVIR = F4 or clinical cirrhosis) in chronic hepatitis C(CHC) patients. Additionally, to compare the accuracy of the MMs with the aspartate aminotransferase to platelet ratio index(APRI) and fibrosis index based on four factors(FIB-4). METHODS Sixty-nine patients who had undergone biopsy in the previous 12 mo or had clinical cirrhosis were included. The presence of any other liver disease was a criterion for exclusion. The MMs, constructed using partial least squares discriminant analysis and linear discriminant analysis formalisms, were tested by cross-validation, considering SF, AF and C. RESULTS Results showed that forty-two patients(61%) presented SF, 28(40%) AF and 18(26%) C. The MMs showed sensitivity and specificity of 97.6% and 92.6% to predict SF; 96.4% and 95.1% to predict AF; and 100% and 98.0% to predict C. Besides that, the MMs correctly classified all 27(39.7%) and 25(38.8%) patients with intermediate values of APRI and FIB-4, respectively. CONCLUSION The metabonomic strategy performed excellently in predicting significant and advanced liver fibrosis in CHC patients, including those in the gray zone of APRI and FIB-4, which may contribute to reducing the need for these patients to undergo liver biopsy. | Andrea Dória Batista Carlos Jonnatan Pimentel Barros Tássia Brena Barroso Carneiro Costa Michele Maria Goncalves de Godoy Ronaldo Dionísio Silva Joelma Carvalho Santos Mariana Montenegro de Melo Lira Norma ThoméJucá Edmundo Pessoa de Almeida Lopes Ricardo Oliveira Silva | 2018 | World Journal of Hepatology2018，10，1： | 2 |
| 3 | Evolution of nonspecific duodenal lymphocytosis over 2 years of follow-up显示文摘AIM: To assess the evolution of duodenal lymphocytosis(DL), a condition characterized by increased intraepithelial lymphocytes(IELs), over 2 years of follow-up.METHODS: Consecutive patients undergoing upper endoscopy/histology for abdominal pain, diarrhea, weight loss, weakness or other extraintestinal features compatible with celiac disease(CD) were included. Evaluation of IELs infiltrate in duodenal biopsy sampleswas carried out by CD3-immunohistochemistry and expressed as number of positive cells/100 enterocytes. Diagnostic agreement on the IELs count was tested by calculating the weighted k coefficient. All patients underwent serological detection of autoantibodies associated with CD: Ig G and Ig A anti-tissue transglutaminase and endomysium. Each patient underwent further investigations to clarify the origin of DL at baseline and/or in the course of 2 years of follow-up every six months. Autoimmune thyroiditis, intestinal infections, parasitic diseases, bacterial intestinal overgrowth, hypolactasia and wheat allergy were detected. Colonoscopy and enteric magnetic resonance i m a g i n g w e r e p e r f o r m e d w h e n n e c e s s a r y. R i s k factors affecting the final diagnosis were detected by multinomial logistic regression and expressed as OR.RESULTS: Eighty-five patients(16 males, 69 females, aged 34.1 ± 12.5 years) were followed up for a mean period of 21.7 ± 11.7 mo. At baseline, endoscopy/duodenal biopsy, CD3 immunohistochemistry revealed: > 25 IELs/100 enterocytes in 22 subjects, 15-25 IELs in 37 and < 15 IELs in 26. They all had negative serum anti-transglutaminase and anti-endomysium, whilst 5 showed Ig G anti-gliadin positivity. In the course of follow-up, 23 developed CD seropositivity and gluten sensitivity(GS) was identified in 19. Other diagnoses were: 5 Helicobacter pylori infections, 4 jejunal Crohn's disease, 1 lymphocytic colitis and 1 systemic sclerosis. The disease in the remaining 32 patients was classified as irritable bowel syndrome because of the lack of diagnostic evidence. At multivariate analysis, the evolution towards CD was associated with an IELs infiltrate > 25(OR = 1640.4) or 15-25(OR = 16.95), human leukocyte antigen(HLA) DQ2/8(OR = 140.85) or DQA1*0501(OR = 15.36), diarrhea(OR = 5.56) and weakness(OR = 11.57). GS was associated with IELs 15-25(OR = 28.59), autoimmune thyroiditis(OR = 87.63), folate deficiency(OR = 48.53) and diarrhea(OR = 54.87).CONCLUSION: DL may have a multifactorial origin but the IELs infiltrate and HLA are strong predictive factors for CD development and a clinical diagnosis of GS. | Giuseppe Losurdo Domenico Piscitelli Antonio Giangaspero Mariabeatrice Principi Francesca Buffelli Floriana Giorgio Lucia Montenegro Claudia Sorrentino Annacinzia Amoruso Enzo Ierardi Alfredo Di Leo | 2015 | World Journal of Gastroenterology2015，21，24： | 2 |
| 4 | Cerebral oxygen saturation before congenital heart surgery显示文摘 | Kurth CD Steven JL Montenegro LM | 2001 | Ann Thorac Surg2001，72，1： | 1 |
| 5 | Distinct subsets of microRNAs are expressed differentially in the human placentas of patients with preeclampsia 显示文摘 | Pineles BL Romero R Montenegro D | 2007 | Am J Obstet Gynecol2007，196，3： | 1 |
| 6 | General findings of the International Atherosclerosis project显示文摘 | McGarry PA McMahan CA Montenegro MR | 1968 | Lab Invest1968，18，： | 1 |
| 7 | A deficit of calcitriol synthesis may not be the initial factor in the pathogenesis of secondary hyperparathyroidism 显示文摘 | Martinez I Saracho R Montenegro J | 1996 | Nephrol Dial Transplant1996，113，： | 1 |
| 8 | Evidence for a stereotypic difference in post-transcriptional regulation of placental gene expression in preeclampsia and SGA:An explanation for the two different phenotypes? 显示文摘 | Pineles BL Romero R Montenegro D | 2006 | Am J Obstet Gynecol2006，195，6： | 1 |
| 9 | Chitin-based tubes for tissue engineering in the nervous system显示文摘 | Freier T Montenegro R Shan Koh H | 2005 | Biomaterials2005，26，22： | 1 |
| 10 | Identification and parameterization of flow processes in artificial capillary barriers显示文摘 | Kampf M Holfelder T Montenegro H | 2003 | Water Resources Research2003，39，10： | 1 |
| 11 | Differences in extracellular matrix components and cell density during normal and dexamethasone-treated secondary palate development in two strains of mice with different susceptibility to glucocorticoid induced-clefting显示文摘 | Montenegro MA Rojas M Dominguez S | 1998 | Craniofac Genet Dev Biol1998，18，2： | 1 |
| 12 | Cytokineresponses during acute simian Plasmodium cynomolgi and Plas- modiumknowlesi infections显示文摘 | Praba-Egge AD Montenegro S Cogswell FB | 2002 | Am J Trop Med Hyg2002，67，6： | 1 |
| 13 | Attenuation of endoplasmic reticulum stress using the chemical chaperone 4 phenylbutyric acid prevents cardiac fibrosis induced by isoproterenol显示文摘 | Ayala P Montenegro J Vivar R | 2012 | Exp Mol Pathol2012，92，1： | 1 |
| 14 | Indigenous health in Latin America and the Caribbean显示文摘 | Raul A Montenegro Carolyn Stephens | 2006 | The Lancet2006，，9525： | 1 |
| 15 | 6LoWPAN ad hoc on-demand distance vector routing (LOAD)显示文摘 | Kim K Park S D Montenegro G | 2007 | Network Working Group Internet Draff(work in progress)2007，802，1： | 1 |
| 16 | Spatial temporal variability of electrical conductivity of groundwater in the semiarid region of Pernambuco, Brazil显示文摘 | Andrade T S Montenegro S M Montenegro A A | 2012 | Revista Brasileira de Engenharia Agricola e Ambiental2012，16，5： | 1 |
| 17 | Cytotoxic Effects of Gold Nanoparticles:A Multiparametric Study显示文摘 | Soenen S J Manshian B Montenegro J M | 2012 | ACS Nano2012，6，7： | 1 |
| 18 | Differences in extracellular matrix components and cell density during normal and dexamethasone-treated secondary palate development in two strains of mice with different susceptibility to glucoeortieoid induced-clefting显示文摘 | MONTENEGRO MA ROJIAS M DOMINGUEZ S | 1998 | J Craniofac Genet Dev Biol1998，18，2： | 1 |
| 19 | 显示文摘 | Ramos SG Montenegro AP Goissis G | 1994 | Pathol Int1994，44，9： | 1 |
| 20 | Ethnicity affects the distribution of delta-aminolevulinic acid dehydratase (ALAD) genetic variants显示文摘 | MONTENEGRO M F BARBOSA F JR SANDRIM V C | 2006 | Clin Chim Acta2006，367，： | 1 |
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