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| 1 | Nose-to-brain delivery of macromolecules mediated by cell-penetrating peptides显示文摘Brain delivery of macromolecular therapeutics(e.g., proteins) remains an unsolved problem because of the formidable blood–brain barrier(BBB). Although a direct pathway of nose-to-brain transfer provides an answer to circumventing the BBB and has already been intensively investigated for brain delivery of small drugs,new challenges arise for intranasal delivery of proteins because of their larger size and hydrophilicity. In order to overcome the barriers and take advantage of available pathways(e.g., epithelial tight junctions, uptake by olfactory neurons, transport into brain tissues, and intra-brain diffusion), a low molecular weight protamine(LMWP) cell-penetrating peptide was utilized to facilitate nose-to-brain transport. Cell-penetrating peptides(CPP)have been widely used to mediate macromolecular delivery through many kinds of biobarriers. Our results show that conjugates of LMWP–proteins are able to effectively penetrate into the brain after intranasal administration.The CPP-based intranasal method highlights a promising solution for protein therapy of brain diseases. | Tingting Lin Ergang Liu Huining He Meong Cheol Shin Cheol Moon Victor C.Yang Yongzhuo Huang | 2016 | Acta Pharmaceutica Sinica B2016，6，4： | 4 |
| 2 | High-performance all-polymer solar cells enabled by a novel low bandgap non-fully conjugated polymer acceptor显示文摘The non-fully conjugated polymer as a new class of acceptor materials has shown some advantages over its small molecular counterpart when used in photoactive layers for all-polymer solar cells(all-PSCs),despite a low power conversion efficiency(PCE)caused by its narrow absorption spectra.Herein,a novel non-fully conjugated polymer acceptor PFY-2TS with a low bandgap of~1.40 eV was developed,via polymerizing a largeπ-fused small molecule acceptor(SMA)building block(namely YBO)with a non-conjugated thioalkyl linkage.Compared with its precursor YBO,PFY-2TS retains a similar low bandgap but a higher LUMO level.Moreover,compared with the structural analog of YBO-based fully conjugated polymer acceptor PFY-DTC,PFY-2TS shows a similar absorption spectrum and electron mobility,but significantly different molecular crystallinity and aggregation properties,which results in optimal blend morphology with a polymer donor PBDB-T and physical processes of the device in all-PSCs.As a result,PFY-2TS-based all-PSCs achieved a PCE of 12.31%with a small energy loss of 0.56 eV enabled by the reduced non-radiative energy loss(0.24 eV),which is better than that of 11.08%for the PFY-DTC-based ones.Our work clearly demonstrated that non-fully conjugated polymers as a new class of acceptor materials are very promising for the development of high-performance all-PSCs. | Qunping Fan Ruijie Ma Tao Liu Jianwei Yu Yiqun Xiao Wenyan Su Guilong Cai Yuxiang Li Wenhong Peng Tao Guo Zhenghui Luo Huiliang Sun Lintao Hou Weiguo Zhu Xinhui Lu Feng Gao Ellen Moons Donghong Yu He Yan Ergang Wang | 2021 | Science China Chemistry2021，64，8： | 3 |
| 3 | Background exposure of urban populations to lead and cadmium: comparison between China and Japan显示文摘 | Zuo-Wen Zhang Chan-Seok Moon Takao Watanabe Shinichro Shimbo Feng-Sheng He Y.-Q. Wu Shun-Fu Zhou De-Ming Su Jiang-Bin Qu M. Ikeda | 1997 | International Archives of Occupational and Environmental Health1997，，4： | 1 |
| 4 | Metastasisassociated protein 1 enhances angiogenesis by stabilization of HIF-1α显示文摘 | Moon HE Cheon H Chun KH | | 0，，04： | 1 |
| 5 | Metastasis- associated protein 1 enhances angiogenesis by stabilization of HIF-1 α 显示文摘 | Moon HE Cheon H Chun KH etal | 2006 | Oncol Rep2006，16，4： | 1 |
| 6 | Metastasis-associated protein 1enhances angiogenesis by stabilization of HIF-lalpha显示文摘 | Moon HE Cheon H Chun KH | 2006 | Oncol Rep2006，16，4： | 1 |
| 7 | Metastasis-associated protein 1 enhances angiogenesis by stabilization of HIF-1α 显示文摘 | Moon HE Cheon H Chun K-H | 2006 | Oncol Rep2006，16，： | 1 |
| 8 | Metastasis-associated protein 1 inhibits p53-induced apoptosis显示文摘 | Moon HE Cheon H Lee MS | 2007 | Oncol Rep2007，18，5： | 1 |
| 9 | Metastasis- associated protein 1 enhances angiogenesis by stabilization of HIF-1alpha显示文摘 | Moon HE Cheon H Chun KH | 2006 | OncolRep2006，16，4： | 1 |
| 10 | Metastasis-associated protein 1 enhances angiogenesis by stabilization of HIF-1 alpha显示文摘 | Moon HE Cheon H Chun KH | 2006 | Oncol Rep2006，16，4： | 1 |
| 11 | Hypoxia-induced angiogenesis in human hepatocel|ular carcinoma显示文摘 | Kim KR HE Moon KW Kim | 2002 | Mol Med2002，80，11： | 1 |
| 12 | Hypoxia-induced angiogenesis in human hepatocellular carcinoma 显示文摘 | Kim KR Moon HE Kim KW | 2002 | J Mol Med2002，80，11： | 1 |
| 13 | Metastasis-assecisted protein 1 enhances angiogenosis by stabilzation of H1F-1 alpha显示文摘 | CHEON H CHUN KH | 2006 | Oncol Rep2006，16，4： | 1 |
| 14 | Loss of mitochandrial DNA enhances angiogenic and invasive potential of hepatoma ceils 显示文摘 | Cheon H Moon HE Lee MS | 2010 | Oncol Rep2010，23，3： | 1 |
| 15 | Metastasis-associated protein1 inhibits p53-induced apoptosis显示文摘 | Moon HE Cheon H Lee MS | 2007 | Oncol Rep2007，18，5： | 1 |
| 16 | Hypoxia-induced angiogenesis in human hepatocellular carcinoma显示文摘 | Kim KR Moon HE Kim KW | 2002 | J Mol Med2002，80，11： | 1 |
| 17 | Effect of blast-induced vibration on existing tunnels in soft rocks 显示文摘 | Jong He Shin Hoon Gi Moon Sung Eun Chae | 2011 | Tunnelling and Underground Space Technology2011，，26： | 1 |
| 18 | Metastasis-associated protein1enhances angiogenesis by stabilization of HIF-1alpha显示文摘 | Moon HE Cheon H Chun KH | 2006 | Oncol Rep2006，16，4： | 1 |
| 19 | Metastasisassociated protein 1 enhances angiogenesis by stabilization of HIF-1α显示文摘 | Moon HE Cheon H Chun KH | 2006 | Oncol Rep2006，16，4： | 1 |
| 20 | Metastasis-associated pro-tein 1 enhances angiogenesis by stabilization of HIF-1alpha显示文摘 | Moon HE Cheon H Chun KH | 2006 | Oncol Rep2006，16，4： | 1 |
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