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| 1 | Benefit of neoadjuvant concurrent chemoradiotherapy for locally advanced perihilar cholangiocarcinoma显示文摘AIM To clarify the role of neoadjuvant concurrent chemoradiotherapy(NACCRT) followed by surgical resection for localized or locally advanced perihilar cholangiocarcinoma(CCA).METHODS We retrospectively reviewed 57 patients who underwent surgical resection with or without NACCRT for perihilar CCA; 12 patients received NACCRT and 45 patients did not received NACCRT. Patients with locally advanced perihilar CCA requiring NACCRT were defined as follows:(1) a mass involving unilateral branches of the portal vein or hepatic artery with insufficient volume of the anticipated remnant lobe; or(2) an infiltrating mass in the main portal vein that was too long for reconstruction, identified at preoperative staging. RESULTS The median disease-free survival(DFS) durations of the neoadjuvant and non-neoadjuvant CCRT groups were26.0 and 15.1 mo, respectively(P = 0.91). The median overall survival(OS) durations of the neoadjuvant and non-neoadjuvant CCRT groups were 32.9 and 27.1 mo, respectively(P = 0.26). The NACCRT group showed a downstaging tendency compared to the non-NACCRT group as compared with the tumor stage confirmed by histological examination after surgery and the tumor stage confirmed by imaging test at the time of diagnosis(P = 0.01). CONCLUSION NACCRT does not prolong DFS and OS in localized or locally advanced perihilar CCA. However, NACCRT may allow tumor downstaging and improve tumor resectability. | Jang Han Jung Hyun Jik Lee Hee Seung Lee Jung Hyun Jo In Rae Cho Moon Jae Chung Jeong Youp Park Seung Woo Park Si Young Song Seungmin Bang | 2017 | World Journal of Gastroenterology2017，23，18： | 21 |
| 2 | Comparison of efficacy and safety between standard-dose and modified-dose FOLFIRINOX as a first-line treatment of pancreatic cancer显示文摘AIM To directly compare the efficacy and toxicity of standarddose FOLFIRINOX(sFOLFIRINOX) and modified-dose FOLFIRINOX(mFOLFIRINOX, 75% of standard-dose) for pancreatic cancer.METHODS One hundred and thirty pancreatic cancer patients who received sFOLFIRINOX(n = 88) or mFOLFIRINOX(n = 42) as their first-line chemotherapy from January 2013 to July 2017 were retrospectively reviewed. For efficacy analysis, the objective response rate(ORR),disease control rate(DCR), progression-free survival(PFS), and overall survival(OS) were evaluated and compared using Pearson's chi-square test, Kaplan-Meier plot and log-rank test. The adverse events(AEs) were evaluated, and severe(≥ grade 3) AEs rates of the two groups were compared for toxicity analysis.RESULTS The mFOLFIRINOX group included more female patients(30.7% vs 57.1%; P = 0.004) and older patients [age(median), 57 vs 63.5; P = 0.018] than the sFOLFIRINOX group. In the efficacy analysis, the ORR and DCR were not significantly different between the two groups(ORR: 39.8% vs 35.7%; P = 0.656; DCR: 80.7% vs 83.3%; P = 0.716). The median PFS and OS were also not different between the groups(PFS: 8.7 mo vs 8.1 mo, P = 0.272; OS: 13.9 mo vs 13.7 mo, P = 0.476). In the safety analysis with severe AEs, the rates of neutropenia(83.0% vs 66.7%; P = 0.044), anorexia(48.9% vs 28.6%; P = 0.029) and diarrhea(13.6% vs 0.0%; P = 0.009) were markedly lower in the mFOLFIRINOX group.CONCLUSION m FOLFIRINOX showed comparable efficacy but better safety compared to sFOLFIRINOX. If clinically necessary, initiating FOLFIRINOX with 75% of the standard-dose can alleviate toxicity concerns without compromising efficacy. | Huapyong Kang Jung Hyun Jo Hee Seung Lee Moon Jae Chung Seungmin Bang Seung Woo Park Si Young Song Jeong Youp Park | 2018 | World Journal of Gastrointestinal Oncology2018，10，11： | 6 |
| 3 | Differential diagnosis between gallbladder adenomas and cholesterol polyps on contrast-enhanced harmonic endoscopic ultrasonography显示文摘 | Chan Hyuk Park Moon Jae Chung Tak Geun Oh Jeong Youp Park Seungmin Bang Seung Woo Park Hyunki Kim Ho Kyoung Hwang Woo Jung Lee Si Young Song | 2013 | Surgical Endoscopy2013，，4： | 2 |
| 4 | Endoscopic Papillary Large Balloon Dilatation Alone Is Safe and Effective for the Treatment of Difficult Choledocholithiasis in Cases of Billroth II Gastrectomy: A Single Center Experience显示文摘 | Hui Won Jang Kyong Joo Lee Moon Jae Jung Joo Won Jung Jeong Youp Park Seung Woo Park Si Young Song Jae Bock Chung Seungmin Bang | 2013 | Digestive Diseases and Sciences2013，，6： | 2 |
| 5 | Comparison between laparoscopy and noninvasive tests for the diagnosis of tuberculous peritonitis显示文摘 | Hong KD Lee SI Moon HY | | 0，，11： | 1 |
| 6 | Usefulness and safety of ultrasound-guided percutaneous needle biopsy in renal allograft patients显示文摘 | Kim SI Moon JI Kim MS | 1998 | Transplant Proc1998，30，7： | 1 |
| 7 | Gets Sensing Properties of Printed MultiwaUed Carbon Nanotubes Using the Field Emission Effect显示文摘 | Lee YD Cho WS Moon SI | 2006 | Chemical Physics Letters2006，433，： | 1 |
| 8 | Continuous separation of breast cancer ceils from blood samples using multi-orifice flow fractionation (MOFF) and dielectrophoresis (DEP) 显示文摘 | Moon HS Kwon K Kim SI | 2011 | Lab Chip2011，11，6： | 1 |
| 9 | A case of bleeding from the Dieulafoy lesion of the jejunum显示文摘 | Lee KS Moon YJ Lee SI | | 0，，： | 1 |
| 10 | Comparison between laparoscopy and noninvasive tests for the diagnosis of tuberculous peritonitis显示文摘 | Hong KD Lee SI Moon HY | 2011 | World J Surg2011，35，11： | 1 |
| 11 | Polycyclic aromatic hydrocar- bon- induced oxidative stress, antioxidant capacity, and the risk of lung cancer : a pilot nested case - control study 显示文摘 | Eom SY Yim DH Moon SI | 2013 | Anticancer Res2013，33，8： | 1 |
| 12 | Changes in blood glucose and cortisol levels atter epidural or shoulder intra-articular glucoeortieoid injections in diabetic or nondiabetic patients 显示文摘 | Moon H J Choi KH Lee SI | 2014 | American Journal of Physical Medicine and Rehabilitation2014，93，5： | 1 |
| 13 | Serum response factor enhances liver metastasis of colorectal carcinomavia alteration of the E-cadherin/β-catenin complex显示文摘 | Ha Choi Kyung Kim Ji Lee Ho Park Kyu Jang Myoung Chung Si Hwang Hee Yu Woo Moon | 2009 | Oncology Reports2009，，1： | 1 |
| 14 | Segmental pedicle screw fixation in the treatment of thoracic idiopathic scoliosis显示文摘 | Suk SI Lee HM Moon SH | 1995 | Spine1995，20，12： | 1 |
| 15 | Establishment and Maintenance of Human Embryonic Stem Cells on STO, a Permanently Growing Cell Line显示文摘 | Moon SY Roh SI Kim CG | 2003 | Biology of Reproduction2003，69，2： | 1 |
| 16 | Removal of NO from flue gas by aqueous chlorine-dioxide scrubbing solution in a lab-scale bubbling reactor显示文摘 | Bal Raj Deshwal Dong Seop Jin Si Hyun Lee Seung Hyun Moon Jong Hyeon Jung Hyung Keun Lee | 2007 | Journal of Hazardous Materials2007，，3： | 1 |
| 17 | Genetic load and transgenic mitigating genes in transgenic Brassica rapa (field mustard) × Brassica napus (oilseed rape) hybrid populations 显示文摘 | Rose CW Millwood RJ Moon HS Rao MR Halfhill MD Raymer PL Warwick4 SI Al-Ahmad H Gressel J and Stewart Jr CN | 2009 | BMC Biotechnol2009，9，： | 1 |
| 18 | Comparison between laparoscopy and noninvasive tests for the diagnosis of tuberculous peritonitis显示文摘 | Hong KD Lee SI Moon HY | 2011 | World J Surg2011，35，11： | 1 |
| 19 | Melt/Solid polycondensation of L_Lactic acid:an alternative route to poly(L-Latic acid) with high molecular weight显示文摘 | Moon SI Lee CW | 2001 | Polymer2001，42，31： | 1 |
| 20 | Continuous separation of breast cancer cells from blood samples using muhiorifice flow fractionation (MOFF) and dielectrophoresis (DEP) 显示文摘 | Moon HS Kwon K Kim SI | 2011 | Lab Chip2011，11，6： | 1 |
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