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| 1 | Ophthalmic manifestations in patients with inflammatory bowel disease: a review显示文摘Clinical manifestations of inflammatory bowel disease(IBD) are not locally restricted to the gastrointestinal tract, and a significant portion of patients have involvement of other organs and systems. The visual system is one of the most frequently affected, mainly by inflammatory disorders such as episcleritis, uveitis and scleritis. A critical review of available literature concerning ocular involvement in IBD, as it appears in Pub Med, was performed. Episcleritis, the most common ocular extraintestinal manifestation(EIM), seems to be more associated with IBD activity when compared with other ocular EIMs. In IBD patients, anterior uveitis has an insidious onset, it is longstanding and bilateral, and not related to the intestinal disease activity. Systemic steroids or immunosuppressants may be necessary in severe ocular inflammation cases, and control of the underlying bowel disease is important to prevent recurrence. Our review revealed that ocular involvement is more prevalent in Crohn's disease than ulcerative colitis, in active IBD, mainly in the presence of other EIMs. The ophthalmic symptoms in IBD are mainly nonspecific and their relevance may not be recognized by the clinician; most ophthalmic manifestations are treatable, and resolve without sequel upon prompt treatment. A collaborative clinical care team for management of IBD that includes ophthalmologists is central for improvement of quality care for these patients, and it is also cost-effective. | Leandro Lopes Troncoso Ana Luiza Biancardi Haroldo Vieira de Moraes Jr Cyrla Zaltman | 2017 | World Journal of Gastroenterology2017，23，32： | 7 |
| 2 | Gut homing receptors on CD8 T cells are retinoic acid dependent and not maintained by liver dendritic or stellate cells显示文摘 | Eksteen B Mora JR Haughton EL | 2009 | Gastroenterology2009，137，1： | 1 |
| 3 | Code validation for high-speed flow simulation over satellite launch vehicle 显示文摘 | Azevedo J L F Moraes P Jr | 1996 | Journal of Spacecraft and Rockets1996，30，1： | 1 |
| 4 | Prognostic implications of tumor-infiltrating lymphocytes in association with programmed cell death ligand 1 expression in remnant gastric cancer显示文摘Objective:Remnant gastric cancer(RGC)is usually associated with a worse prognosis.As they are less common and very heterogeneous tumors,new prognostic and reliable determinants are required to predict patients’clinical course for RGC.This study aimed to investigate the tumor-infiltrating lymphocytes(TILs)and programmed cell death ligand 1(PD-L1)status as prognostic biomarkers in a cohort of patients with RGC to develop an immunerelated score.Methods:Patients with gastric cancer(GC)who underwent curative intent gastrectomy were retrospectively investigated.RGC resections with histological diagnosis of gastric adenocarcinoma were enrolled in the study.The risk score based on immune parameters was developed using binary logistic regression analysis.RGCs were divided into high-risk(HR),intermediate-risk(IR),and low-risk(LR)groups based on their immune score.The markers(CD3+,CD4+/CD8+T cells and PD-L1)were selected for their potential prognostic,therapeutic value,and evaluated by immunohistochemistry(IHC).Results:A total of 42 patients with RGC were enrolled in the study.The score based on immune parameters exhibited an accuracy of 79%[the area under the receiver operating characteristic curve(AUC)=0.79,95%confidence interval(95%CI),0.63-0.94,P=0.002],and the population was divided into 3 prognostic groups:10(23.8%)patients were classified as LR,15(35.7%)as IR,and 17(40.5%)as HR groups.There were no differences in clinicopathological and surgical characteristics between the three groups.In survival analysis,HR and IR groups had worse disease-free survival and overall survival rates compared to the LR group.In the multivariate analysis,lymph node metastasis and the immune score risk groups were independent factors related to worse survival.Conclusions:A scoring system with immune-related markers was able to distinguish prognostic groups of RGC associated with survival.Accordingly,tumor-infiltrating immune lymphocytes and PD-L1 status may serve as a potential prognostic biomarker for patients with RGC. | Marina Alessandra Pereira Marcus Fernando Kodama Pertille Ramos André Roncon Dias Leonardo Cardili Rafael Dyer Rodrigues de Moraes Renan Ribeiro E Ribeiro Venancio Avancini Ferreira Alves Bruno Zilberstein Evandro Sobroza de Mello Ulysses Ribeiro Jr | 2022 | Chinese Journal of Cancer Research2022，34，6： | 1 |
| 5 | Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells显示文摘 | Iwata M Eksteen B | 2006 | Science2006，314，： | 1 |
| 6 | Selective imprinting of gut-homing T cells by Peyer ' s patch dendritic cells 显示文摘 | Mora JR Bono MR Manjunath N | 2003 | Nature2003，424，6944： | 1 |
| 7 | Reciprocal and dynamic control of CD8 T cell homing by dendritic cells from skin- and gut?associated lymphoid tissues 显示文摘 | Mora JR Cheng G Picarella D | 2005 | J Exp Med2005，201，2： | 1 |
| 8 | Manifestations of insulin-dependent diabetes mellitus in the periodontium of young Brazilian patients显示文摘 | Novaes AB Jr Pereira AL De moraes N | 1991 | J Periodontol1991，62，： | 1 |
| 9 | Self-focusing and Raman scattering of laser pulses in tenuous plasmas显示文摘 | Jr Mora P | 1992 | Phys Rev Lett1992，69，： | 1 |
| 10 | Differentiation and homing of IgA- secreting cells显示文摘 | Mora JR Von Andrian UH | 2008 | Mucosal Immunol2008，1，2： | 1 |
| 11 | Differentiation and homing of IgA-secreting cells显示文摘 | Mora JR yon Andfian UH | 2008 | Mucosal Immunol2008，1，2： | 1 |
| 12 | Cyclosporine preconditions dentrictic cells during differentiation and reduces IL-2 and IL-12 prodction following activation:a potential tolerogenic effect显示文摘 | Sauma D Fierro A Mora JR | 2003 | Transplant Proce2003，35，： | 1 |
| 13 | Role of retinoic acid in the imprinting of gut homing IgA secreting cells显示文摘 | Mora JR yon Andrian UH | 2009 | Semin Immunol2009，21，1： | 1 |
| 14 | Homing imprinting and immunomodulation in the gut : role of dendritic cells and retinoids显示文摘 | Mora JR | 2008 | Inflamm Bowel Dis2008，14，2： | 1 |
| 15 | Vitamin effects on the immune system: vitamins A and D take centre stage显示文摘 | Mora JR Iwata M von Andrian UH | 2008 | Nat Rev Immunol2008，8，9： | 1 |
| 16 | Optimization of acid hydrolysis from the hemicellulosic fraction of Eucalyptus grandis residue using response surface methodology显示文摘 | Canettieri E V de Moraes Rocha G J de Carvalho J A Jr | 2007 | Bioresour Technol2007，98，2： | 1 |
| 17 | High-fat diet induces apoptosis of hypothalamic neurons显示文摘 | Moraes JC Coope A Morari J Cintra DE Roman EA Pauli JR | 2009 | PLo S One2009，4，4： | 1 |
| 18 | Compatibility of Neoseiulus Paspalivorus and Proctolaelaps Bickleyi, Candidate Bioeontrol Agents of the Coconut Mite Aceria Guerreronis: Spatial Niche Use and Intraguild Predation显示文摘 | BALAGBO L M L GONDIM Jr M G C MORAES G J | 2008 | Exp Appl Aearol2008，45，12： | 1 |
| 19 | Vitamin effects on the im- mune system: vitamins A and D take centre stage 显示文摘 | Mora JR Iwata M Von Andrian UH | 2008 | Nat Rev Im- munol2008，8，9： | 1 |
| 20 | T-cell homing specificity and plasticity: new concepts and future challenges显示文摘 | MORA JR von ANDRIAN UH | 2006 | Trends Immunol2006，27，5： | 1 |
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