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| 1 | Upregulation of the APE1 and H2AX genes and miRNAs involved in DNA damage response and repair in gastric cancer显示文摘Gastric cancer remains one of the leading causes of cancer-related death worldwide,and most of the cases are associated with Helicobacter pylori infection.This bacterium promotes the production of reactive oxygen species(ROS),which cause DNA damage in gastric epithelial cells.In this study,we evaluated the expression of important genes involved in the recognition of DNA damage(ATM,ATR,and H2AX)and ROS-induced damage repair(APE1)and the expression of some miRNAs(miR-15a,miR-21,miR-24,miR-421 and miR-605)that target genes involved in the DNA damage response(DDR)in 31 fresh tissues of gastric cancer.Cytoscape v3.1.1 was used to construct the postulated miRNA:mRNA interaction network.Analysis performed by real-time quantitative PCR exhibited significantly increased levels of the APE1(RQ=2.55,p<0.0001)and H2AX(RQ=2.88,p=0.0002)genes beyond the miR-421 and miR-605 in the gastric cancer samples.In addition,significantly elevated levels of miR-21,miR-24 and miR-421 were observed in diffuse-type gastric cancer.Correlation analysis reinforced some of the gene:gene(ATM/ATR/H2AX)and miRNA:mRNA relationships obtained also with the interaction network.Thus,our findings show that tumor cells from gastric cancer presents deregulation of genes and miRNAs that participate in the recognition and repair of DNA damage,which could confer an advantage to cell survival and proliferation in the tumor microenvironment. | Fernanda S.Manoel-Caetano Ana Flávia T.Rossi Gabriela Calvet de Morais Fábio Eduardo Severino Ana Elizabete Silva | 2019 | Genes & Diseases2019，6，2： | 5 |
| 2 | A quantitative study of silver-stained NORs in different segments of the normal human colorectal cypt显示文摘 | Morais M Dockery P White F | | 0，，： | 1 |
| 3 | Superior vena cava syndrome as tumour presentation显示文摘 | Pires N F Morais A QueirogaH | | 0，，1： | 1 |
| 4 | Stress-induced anhedonia is associated with hypertrophy of medium spiny neurons of the nucleus accumbens显示文摘 | BESSA J M MORAIS M MARQUES F | 2013 | Translational Psychiatry2013，3，： | 1 |
| 5 | Subclinical hypothyroidism represents an additional risk factor for coronary artery calcification,especially in subjects with intermediate and high cardiovascular risk scores显示文摘 | Silva N Santos O Morais F | 2014 | Eur J Endocrinol2014，171，3： | 1 |
| 6 | An examination of the determinants of entertainment vacationers' intentions to revisit 显示文摘 | ]PETRICK J F MORAIS D D NORMAN W C | 2001 | Journal of Travel Research2001，40，1： | 1 |
| 7 | Biomaterialst tissue interactions: possible solutions to overcome foreign body re- sponse显示文摘 | Morais J M Papadimitrakopoulos F Burgess D J | 2010 | AAPS J2010，12，2： | 1 |
| 8 | Combined effects of chemical dip and/or carrageenan coating and/or controlled atmo- sphere on quality of fresh-cut banana显示文摘 | BICO S L S RAPOSO M F J MORAIS R M S C | 2009 | Food Control2009，20，5： | 1 |
| 9 | 显示文摘 | Tourinho F A Morais P C Sousa M H | 1996 | Proceedings of SPIE - The International Society for Optical Engineering1996，2779，： | 1 |
| 10 | Duplex reverse transcription-PCR followed by nested PCR assays for detection and identification of Brazilian alphaviruses and flaviviruses显示文摘 | Morais Bronzoni R V Baleotti F G Ribierra Nogueira M R | 2005 | Clin Microbiol2005，43，： | 1 |
| 11 | An examination of the determination of entertainment cationers' intentions to revisit显示文摘 | Petrick J F Morais D D Norman W C | 2001 | Journal of Travel Research2001，，： | 1 |
| 12 | Combined effects of chemical dip and/or carrageenan coating and/or contolled atmosphere on quality of fresh-cut banana显示文摘 | BICO S L S RAPOSO M F J MORAIS R M S C | 2009 | Food Control2009，20，： | 1 |
| 13 | Evolutionary view of acyl - CoA diacylglycerol acyl- transferase (DGAT) , a key enzyme in neutral lipid bio- synthesisa显示文摘 | Turchetto- Zolet A C Maraschin F S de Morais G L D | 2011 | BMC Evolutionary Biology2011，11，1： | 1 |
| 14 | Combined effects of chemical dip and/or carrageenan coating and/or con- trolled atmosphere on quality of fresh-cut banana显示文摘 | Bico S L S Raposo M F J Morais R M S C | 2009 | Food Con- trol2009，20，50： | 1 |
| 15 | Biosensor based on multi-walled carbon nanotubes paste electrode modified with laccase for pirimicarb pesticide quantification显示文摘 | OLIVEIRA T M B F BARROSO M F MORAIS S | | 0，，： | 1 |
| 16 | Vascular complications after liver transplantation in pediatric patients显示文摘 | Moray G Boyvat F Sevmis S | 2005 | Transplant Proc2005，37，7： | 1 |
| 17 | Systems of p-Laplacean equations involving homogeneous nonlinearities with critical Sobolev exponent degrees显示文摘 | Morais F D C Souto M A S | | 0，，： | 1 |
| 18 | Delayed graft function: predictive factors and impact on outcome in living related kidney transplantations显示文摘 | SEAEL F M KARAKATALI H MORAY G | 1998 | Ren Fail1998，20，： | 1 |
| 19 | Micro- structural analysis and tensile properties of squeeze cast Al-7Mg alloy显示文摘 | CARDOSO D B C DIAS M F MORAIS C A L | 2010 | Materials Science Forum2010，643，： | 1 |
| 20 | Combined effects of chemical dip and/or carrageenan coating and/or con- trolled atmosphere on quality of fresh-cut banana显示文摘 | Bico S L S Raposo M F J Morais R M S C | 2009 | Food Con- trol2009，20，50： | 1 |
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