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| 1 | The causes of land-use and land-cover change: moving beyond the myths显示文摘 | Eric F. Lambin B.L. Turner Helmut J. Geist Samuel B. Agbola Arild Angelsen John W. Bruce Oliver T. Coomes Rodolfo Dirzo Günther Fischer Carl Folke P.S. George Katherine Homewood Jacques Imbernon Rik Leemans Xiubin Li Emilio F. Moran Michael Mortimore P.S. | 2001 | Global Environmental Change2001，，4： | 2 |
| 2 | Clinical predictors of thiopurine-related adverse events in Crohn's disease显示文摘AIM: To determine the incidence and predictors of thiopurine-related adverse events. METHODS: Subjects with Crohn's disease who were followed in the Alberta Inflammatory Bowel Disease Consortium patient database registry were identified. Retrospective chart review was conducted between August 5th, 2010 and June 1st, 2012. We collected data on: age at diagnosis; sex; disease location and behaviour at time of prescribing thiopurine; perianal fistulising disease at or prior to thiopurine prescription; smoking status at time of thiopurine prescription, use of corticosteroid within 6 mo of diagnosis; dosage, age at onset, and cessation of 5-aminosalicyclic acid(5-ASA); anti-tumour necrosis factor medication exposure and intestinal resection before thiopurine prescription. The primary outcome of interest was the first adverse event that led to discontinuation of the first thiopurine medication used. Logistic regression models were used to associate clinical characteristics with outcomes after adjusting for potential confounders. Risk estimates were presented as odds ratios(OR) with 95% CI. Effect modification by age and sex were explored.RESULTS: Our cohort had a median follow-up duration of 5.8 years [interquartile range(IQR 25th-75th) 2.7-9.1]. Thiopurine therapy was discontinued in 31.3% of patients because of: hypersensitivity reactions(7.1%), acute pancreatitis(6.2%), gastrointestinal intolerance(5.4%), leucopenia(3.7%), hepatotoxicity(3.4%), infection(1.1%) and other reasons(4.3%). A higher incidence of thiopurine withdrawal was observed in patients over the age of 40(39.4%, P = 0.007). A sexby-age interaction(P = 0.04) was observed. Females older than 40 years of age had an increased risk of thiopurine discontinuation due to an adverse event(age above 40 vs age below 40, adjusted OR = 2.8; 95%CI: 1.4-5.6). In contrast, age did not influence thiopurine withdrawal in males(age above 40 vs below 40, adjusted OR = 0.9; 95%CI: 0.4-2.1). Other clinical variables(disease location and phenotype, perianal disease, smoking history, history of intestinal resection and prior 5-ASA or corticosteroid use) were not associated with an increased risk an adverse event leading to therapy cessation. CONCLUSION: Thiopurine withdrawal due to adverse events is commoner in women over the age of 40 at prescription. These findings need to be replicated in other cohorts. | Gordon W Moran Marie-France Dubeau Gilaad G Kaplan Hong Yang Bertus Eksteen Subrata Ghosh Remo Panaccione | 2015 | World Journal of Gastroenterology2015，21，25： | 2 |
| 3 | Angioimmunoblastic lymphadenopathy with dysproteinaemia显示文摘 | Moran EM Rappaport B | 1974 | Lancet1974，1，： | 1 |
| 4 | Geldanamycin promotes premature mitotic entry and micronucleation in irradiated p53/ p21 deficient colon carcinoma cells显示文摘 | Moran DM Gawlak G Jayaprakash MS | 2008 | Oncogene2008，27，42： | 1 |
| 5 | Early mortality after hip fracture is delay before surgery important? 显示文摘 | MORAN C G WENN R T SIKAND M | 2005 | J B one Joint Surg (A m)2005，87，3： | 1 |
| 6 | Optical lightpipe as a high -band width fusion diagnostic显示文摘 | Moran M J Lerche R A G Mant | 2006 | Rev Sci Inslrum2006，77，10： | 1 |
| 7 | Optimal total mesorectal excision for rectal cancer is by dissection in front of Denovillier's fascia显示文摘 | Heald RJ Moran J Brow G | 2004 | Br J Surg2004，91，1： | 1 |
| 8 | Early mortality after hipfractrue显示文摘 | Moran C G | 2005 | J Bone Joint Surg(Am)2005，87，3： | 1 |
| 9 | Genomie changes following host restriction in bacteria显示文摘 | MORAN N A PLAGUE G R | 2004 | Current Opinion in Genetics & Devel- opment2004，14，6： | 1 |
| 10 | Anesthesia and evoked re- sponses in neurosurgery显示文摘 | Soghomonyan S Moran K R Sandhu G S | 2014 | Front Pharmacol2014，5，： | 1 |
| 11 | Angio-immunoblastic Lymphadenopathy with dysproteinaemia显示文摘 | Frizzera G Moran EM Rappaport H | 1974 | Lancet1974，1，7866： | 1 |
| 12 | The familial occurrence of agoraphobia 显示文摘 | Moran C Andrews G | 1985 | Br J Psychiatry1985，146，： | 1 |
| 13 | Pulmonary plasmacytomas: a clinicopathologic and immunohistochemical study of five cases显示文摘 | Koss M N Hochholzer L Moran C A Frizzera G | 1998 | Ann Diagn Pathol1998，2，： | 1 |
| 14 | Interaction of (4-hydroxyphenyl) pyruvate dioxygenase with the specific inhibitor 2- - 1,3 -eyelohexanedione 显示文摘 | Kavana M Moran G R | 2003 | Biochemistry2003，42，10： | 1 |
| 15 | Pulmonary artery sarcoma: a clinicopathologic and immunohistochemical study of 12 cases 显示文摘 | Huo L Moran C A Fuller G N | 2006 | Am J Clin Pathol2006，125，： | 1 |
| 16 | Leucovorin enhancement of the effects of the fluoropyrimidines on thymidylate synthase 显示文摘 | Moran R G | 1989 | Cancer1989，63，5： | 1 |
| 17 | Performance analysis of a PWM inverter VAR compensator显示文摘 | JOOS G MORAN L ZIOGAS P | 1991 | IEEE Transac-tions on Power Electronics1991，6，3： | 1 |
| 18 | Effect of the cyanobacterial(blue-green algal) toxins from Microcystis aeruginosa on isolated enterocytes from the chicken small intestine显示文摘 | Facloner I R Dombusch M Moran G | 1992 | Toxicon1992，30，7： | 1 |
| 19 | Angioimmunoblastic lymphadenopathy with dysproteinaemia显示文摘 | Frizzera G Moran EM Rappaort B | 1974 | Lancet1974，7866，： | 1 |
| 20 | Differentiation among cffects of nitrogen fertilization treatments on conifer seedlings by foliar reflectance:a comparison of methods显示文摘 | Moran J A Mitchell A K Goodmanson G Stockburger K A | | 0，，16： | 1 |
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