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| 1 | Clinical predictors of thiopurine-related adverse events in Crohn's disease显示文摘AIM: To determine the incidence and predictors of thiopurine-related adverse events. METHODS: Subjects with Crohn's disease who were followed in the Alberta Inflammatory Bowel Disease Consortium patient database registry were identified. Retrospective chart review was conducted between August 5th, 2010 and June 1st, 2012. We collected data on: age at diagnosis; sex; disease location and behaviour at time of prescribing thiopurine; perianal fistulising disease at or prior to thiopurine prescription; smoking status at time of thiopurine prescription, use of corticosteroid within 6 mo of diagnosis; dosage, age at onset, and cessation of 5-aminosalicyclic acid(5-ASA); anti-tumour necrosis factor medication exposure and intestinal resection before thiopurine prescription. The primary outcome of interest was the first adverse event that led to discontinuation of the first thiopurine medication used. Logistic regression models were used to associate clinical characteristics with outcomes after adjusting for potential confounders. Risk estimates were presented as odds ratios(OR) with 95% CI. Effect modification by age and sex were explored.RESULTS: Our cohort had a median follow-up duration of 5.8 years [interquartile range(IQR 25th-75th) 2.7-9.1]. Thiopurine therapy was discontinued in 31.3% of patients because of: hypersensitivity reactions(7.1%), acute pancreatitis(6.2%), gastrointestinal intolerance(5.4%), leucopenia(3.7%), hepatotoxicity(3.4%), infection(1.1%) and other reasons(4.3%). A higher incidence of thiopurine withdrawal was observed in patients over the age of 40(39.4%, P = 0.007). A sexby-age interaction(P = 0.04) was observed. Females older than 40 years of age had an increased risk of thiopurine discontinuation due to an adverse event(age above 40 vs age below 40, adjusted OR = 2.8; 95%CI: 1.4-5.6). In contrast, age did not influence thiopurine withdrawal in males(age above 40 vs below 40, adjusted OR = 0.9; 95%CI: 0.4-2.1). Other clinical variables(disease location and phenotype, perianal disease, smoking history, history of intestinal resection and prior 5-ASA or corticosteroid use) were not associated with an increased risk an adverse event leading to therapy cessation. CONCLUSION: Thiopurine withdrawal due to adverse events is commoner in women over the age of 40 at prescription. These findings need to be replicated in other cohorts. | Gordon W Moran Marie-France Dubeau Gilaad G Kaplan Hong Yang Bertus Eksteen Subrata Ghosh Remo Panaccione | 2015 | World Journal of Gastroenterology2015，21，25： | 2 |
| 2 | Microcontact printing of catalytic nanoparticles for selective electroless deposition of metals on nonplanar polymeric substrates 显示文摘 | Ng W K Wu L Moran P M | 2002 | Appl Phys Lett2002，81，16： | 1 |
| 3 | Residual stress measurement with focused acoustic waves and direct comparison with X-ray diffraction stress measurements显示文摘 | Moran Thomas J Martin Richard W Rveibel Richard | 2005 | Materials Science and Engineering A2005，399，1： | 1 |
| 4 | Interaction of photochemical and microbial processes in the degradation of refractory dissolved organic matter from a coastal marine environment显示文摘 | Miller W J Moran M A | 1997 | Limonl Oceanogr1997，42，： | 1 |
| 5 | Treatment of material discontinuity in the Element-Free Galerkin method显示文摘 | Cordes L W Moran B | 1996 | Comput methods Appl Mech Engrg1996，139，： | 1 |
| 6 | A simple signal processing architecture for instantaneous radar polarimetry 显示文摘 | Howard S D Calderbank A R Moran W | 2007 | IEEE Transactions on Information Theory2007，53，4： | 1 |
| 7 | Comparisons of male and female broiler responses to dietary threonine from 42 to 56 days of age显示文摘 | Dozier W A Moran Jr E T Kidd M T | 2001 | J ApplPoult Res2001，10，： | 1 |
| 8 | Treatment of material discontinuity in the element-free Galerkin method显示文摘 | Cordes L W Moran B | 1996 | Comput Meth Appl Mech Eng1996，139，： | 1 |
| 9 | Control System for Three Phase Active Power Filter which Simultaneously Compensates Power Factor and Unbalanced Loads显示文摘 | Dixon J W Garcia J J Moran L | 1995 | Trans on Industrial Electronics1995，42，6： | 1 |
| 10 | Intensified CCD (ICCD) dynamic range and noise performance 显示文摘 | MORAN S E ULICH B L ELKINS W P | | SPIE0，3137，： | 1 |
| 11 | A Morphmetric Study of Human Lumbar and Selected Thoracic Vertebrae 显示文摘 | Berry J Moran J M Berg W S | 1987 | Spine1987，12，4： | 1 |
| 12 | Primary intrapulmonary meniugiomas:a elinieopathologic and immu- nohistochemical study of ten cases 显示文摘 | MORAN CA HOCHHOLZER L RUSH W | 1996 | Cancer1996，78，11： | 1 |
| 13 | Control system for three phase active power filter which simultaneously compensates power factor and unbalanced loads显示文摘 | Dixon J W Garcia J J Moran L | 1995 | IEEE Trans on Industrial Electronics1995，42，6： | 1 |
| 14 | Patient personality and mortality: A 4-year prospective examination of chronic renal insufficiency显示文摘 | Christensen A J Ehlers S L Wiebe J S Moran P J Raichle K Ferneyhough K Lawton W J | 2002 | Health Psychology2002，21，4： | 1 |
| 15 | Diagnosis and management of obstructive sleep apnea, a multidisciplinary approach 显示文摘 | Moran W B | 1985 | Arch Otolaryngol1985，111，9： | 1 |
| 16 | Cardiovascular autonomic neuropathy is associated with microalbuminuria in older patients with type 2 diabetes显示文摘 | Moran A Palmas W Field L | 2004 | Diabetes Care2004，27，4： | 1 |
| 17 | Photochemical release of biologically available nitrogen from aquatic dissolved organic matter显示文摘 | Bushaw K L Zepp R G Ta-r M A Schulz-Jander D Bourbonniere R A Hodson R E Miller W L Bronk D A Moran M A | 2002 | Nature2002，381，： | 1 |
| 18 | A simple and low-cost control strategy for active power filters connected in cascade显示文摘 | MORAN L A FERNANDEZ L DIXON J W | 1997 | IEEE Trans Ind Electron1997，44，5： | 1 |
| 19 | Treatment of material discontinuity in the element-free Galerkin method显示文摘 | Cordes L W Moran B | 1996 | Computational Methods of Applied Mechnics and Engineering1996，139，： | 1 |
| 20 | Dissolved organic fluorophores in southeastern US coastal waters: correction method for eliminating Rayleigh and Raman scattering peaks in excitation- emission matrices显示文摘 | Zepp R G Sheldon W M Moran M A | 2004 | Marine Chemistry2004，89，14： | 1 |
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