|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Targeting tumor-associated macrophages and inhibition of MCP-1 reduce angiogenesis and tumor growth in a human melanoma xenograft显示文摘 | Gazzaniga S Bravo A I Guglielmotti A van Rooijen N Maschi F Vecchi A Mantovani A Mordoh J Wainstok R | | 0，，08： | 1 |
| 2 | Natural killer cells in human cancer: From biological functions to clinical applications 显示文摘 | Levy EM Roberti MP Mordoh J | 2011 | J Biomed Biotechnol2011，2011，67： | 1 |
| 3 | Natural killer cells in human can- cer: from biological functions to clinical applications 显示文摘 | Levy EM Roberti MP Mordoh J | 2011 | J Biomed Biotechnol2011，2011，67： | 1 |
| 4 | Targeted inhibition of galectin-1 gene expression in tumor cells results in heightened T cell-mediated rejection显示文摘 | Natalia Rubinstein Mariano Alvarez Norberto W Zwirner Marta A Toscano Juan M Ilarregui Alicia Bravo José Mordoh Leonardo Fainboim Osvaldo L Podhajcer Gabriel A Rabinovich | 2004 | Cancer Cell2004，，3： | 1 |
| 5 | Natural killer cells in human can- cer:from biological functions to clinical applications显示文摘 | Levy EM Roberti MP Mordoh J | 2011 | J Biomed Biotechnol2011，2011，67： | 1 |
| 6 | Biological role of NK cells and immunotherapeutic approaches in breast cancer显示文摘 | Roberti MP Mordoh J Levy EM | 2012 | Front Immunol2012，3，375： | 1 |
| 7 | Natural killer cells in human cancer: from biological functions to clinical applications 显示文摘 | Levg EM Roberti MP Mordoh J | 2011 | Biomed Biotecho12011，2011，67： | 1 |
| 8 | Severe cholestatic hepatitis as the first symptom of secondary syphilis显示文摘 | Ridruejo E Mordoh A Herrera F | 2004 | Dig Dis Sci2004，499，： | 1 |
| 9 | Natural killer ceils in human cancer: from biological functions to clinical applications 显示文摘 | Levy E M Roberti M P Mordoh J | 2011 | J Biomed Biotechno12011，2011，67： | 1 |
| 10 | Natural killer ceils in human canc-er:from biological functions to clinical applications 显示文摘 | Levy EM Roberti MP Mordoh J | 2011 | J Biomed Biotech2011，，： | 1 |
| 11 | 做一个“美食晒照狂”,是怎样的一种体验显示文摘试试看——打开你的Instagram,开始翻阅你自己的推送或者“发现”栏。看到美食的照片了吗?对,可能用不了多久就能看到。在Instagram上美食无处不在。就我个人来讲,通常推送里更多的是我的吃货朋友们的早午餐食物而非真人照。 | Madison Mordoh 蒋琳 | 2017 | 英语广场(美丽英文)2017，0，11： | 0 |
| 12 | A Th2-score in the tumor microenvironment as a predictive biomarker of response to Bacillus Calmette Guérin in patients with non-muscle invasive bladder carcinoma:A retrospective study显示文摘Intravesical Bacillus Calmette Guerin(BCG)is the gold standard therapy for intermediate/high-risk nonmuscle invasive bladder cancer(NMIBC).However,the response rate is~60%,and 50%of non-responders will progress to muscle-invasive disease.BCG induces massive local infiltration of inflammatory cells(Th1)and ultimately cytotoxic tumor elimination.We searched for predictive biomarker of BCG response by analyzing tumor-infiltrating lymphocyte(TIL)polarization in the tumor microenvironment(TME)in pre-treatment biopsies.Pre-treatment biopsies from patients with NMIBC who received adequate intravesical instillation of BCG(n=32)were evaluated retrospectively by immunohistochemistry.TME polarization was assessed by quantifying the T-Bet+(Th1)and GATA-3+(Th2)lymphocyte ratio(G/T),and the density and degranulation of EPX+eosinophils.In addition,PD-1/PD-L1 staining was quantified.The results correlated with BCG response.In most non-responders,Th1/Th2 markers were compared in pre-and post-BCG biopsies.ORR was 65.6%in the study population.BCG responders had a higher G/T ratio and a greater number of degranulated EPX+cells.Variables combined into a Th2-score showed a significant association with higher scores in responders(p=0.027).A Th2-score cut-off value>48.1 allowed discrimination of responders with 91%sensitivity but lower specificity.Relapse-free survival was significantly associated with the Th2-score(p=0.007).In post-BCG biopsies from recurring patients,TILs increased Th2-polarization,probably reflecting BCG failure to induce a pro-inflammatory status and,thus,a lack of response.PD-L1/PD-1 expression was not associated with the response to BCG.Our results support the hypothesis that a preexisting Th2-polarized TME predicts a better response to BCG,assuming a reversion to Th1 polarization and antitumor activity. | GUSTAVO MARTÍN VILLOLDO MARÍA TERESA POMBO MARIANA ARIS JOAQUÍN CHEMI PABLO MANDÓ SUPRIYA NAGARAJU JUAN CAMEAN ADRIÁN BURIONI DEBORAH EGEA MORA AMAT JOSÉLEÓN MELLADO JOSÉMORDOH ALBERTO VILLARONGA MARÍA MARCELA BARRIO | 2023 | Oncology Research2023，31，2： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员