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| 1 | pRB expression in esophageal mucosa of individuals at high risk for squamous cell carcinoma of the esophagus显示文摘AIM: To investigate the pRb expression in a large group of patients with history of chronic exposure to the main risk factors for development of squamous cell carcinoma of the esophagus. METHODS: One hundred and seventy asymptomatic individuals at high risk for esophageal squamous cell carcinoma (consumption of more than 80 g of ethanol and 10 cigarettes/d for at least 10 years) underwent upper gastrointestinal endoscopy with biopsies of the esophageal mucosa. As a control group, specimens of esophageal mucosa obtained from 20 healthy subjects were also studied. Immunohistochemical assessment of the tissues was performed using a monoclonal antibody anti-pRB protein. RESULTS: Absence of the pRB staining, indicating loss of RB function, was observed in 33 (19.4%) of the individuals at risk for esophageal cancer, but in none of the healthy controls (P < 0.02). Loss of pRb expression increased in a stepwise fashion according to the severity of the histological findings (P < 0.005): normal mucosa (11/97 or 11.3%), chronic esophagitis (17/60 or 28.3%), low-grade dysplasia (3/10 or 30%), high-grade dysplasia 1/2 or 50%) and squamous cell carcinoma (1/1 or 100%). CONCLUSION: Our findings suggest that abnormal expression of the pRB protein may be implicated in the process of esophageal carcinogenesis. Additional studies are warranted to define the role of the pRBprotein as a biomarker for development of esophageal squamous cell carcinoma in individuals at high risk for this malignancy. | Simone S Contu Paulo C Contu Daniel C Damin Renato B Fagundes Fabiano Bevilacqua Aline S Rosa Joo C Prolla Luis F Moreira | 2007 | World Journal of Gastroenterology2007，13，11： | 5 |
| 2 | Acute fatty liver of pregnancy associated with severe acute pancreatitis:A case report显示文摘Acute fatty liver of pregnancy is a rare disease that affects women in the third trimester of pregnancy. Although infrequent, the disease can cause maternal mortality. The diagnosis is not always clear until the pregnancy is terminated, and significant complications, such as acute pancreatitis, can occur. Pancreatic involvement typically only occurs in severe cases after the development of hepatic and renal impairment. To date, little knowledge is available regarding how the disease causes pancreatitis. Treatment involves supportive measures and pregnancy interruption. In this report, we describe a case of a previously healthy 26-year-old woman at a gestational age of 27 wk and 6 d who was admitted with severe abdominal pain and vomiting. This case illustrates the clinical and laboratory overlap between acute fatty liver of pregnancy and pancreatitis, highlighting the difficulties in differentiating each disease. Furthermore, the hypothesis for this overlapping is presented, and the therapeutic options are discussed. | Cássio Vieira de Oliveira Alecsro Moreira Julio P Baima Leticia de C Franzoni Talles B Lima Fabio da S Yamashiro Kunie Yabuki Rabelo Coelho Ligia Y Sassaki Carlos Antonio Caramori Ferno G Romeiro Giovanni F Silva | 2014 | World Journal of Hepatology2014，6，7： | 3 |
| 3 | Bovine somatotropin increases embryonic development in superovulated cows and improves posttransfer pregnancy rates when given to lactation recipient cows显示文摘 | Moreira F Bandinga L Burnley C | 2002 | Theriogenology2002，57，： | 1 |
| 4 | Adsorption equilibrium and breakthrough analysis for NO adsorption on activated carbons at low temperatures显示文摘 | Claudino A Soares J L Moreira R F P M | 2004 | Carbon2004，42，： | 1 |
| 5 | Relation between physical properties of the zona pellucida and viability of bovine embryos after slow-freezing and vitrification 显示文摘 | Moreira da silva F Metelo R | 2005 | Reprod Domest Anita2005，40，3： | 1 |
| 6 | High-frequency Modeling for Cable and Induction Motor Overvoltage Studies in Long Cable Drives 显示文摘 | Moreira A F Lipo T A Venkataramanan G | 2002 | IEEE Transactions on Industry Applications2002，38，5： | 1 |
| 7 | Enamel-resin bond durability of self-etch and etch & rinse adhesives显示文摘 | OSORIO R MONTICELLI F MOREIRA M A | 2009 | Am J Dent2009，22，6： | 1 |
| 8 | Electroluminescence of silicon nanocrystals in MOS structures显示文摘 | Franzò G Irrera A Moreira E C Miritello M Iacona F Sanfilippo D Di Stefano G Fallica P G Priolo F | | 0，，： | 1 |
| 9 | Novel in- sights into the genomic basis of citrus canker based on the genome sequences of two strains of Xanthomonas fuscans subsp, aurantifolii 显示文摘 | Moreira L M Almeida N F Potnis N | 2010 | BMC Genomics2010，11，1： | 1 |
| 10 | Speciated ambient carbonyls in Rio de Janeiro, Brazil 显示文摘 | Grosjean D Grosjean E Moreira L F | 2002 | Environmental Science and Technology2002，36，7： | 1 |
| 11 | Hierarchic species- area relationships and the management of forest habitat is- lands in intensive farmland显示文摘 | Lomba A Vaz A S Moreira F | 2013 | Forest Ecology and Man- agement2013，291，： | 1 |
| 12 | Osmotic dehydration kinetics of pumpkin fruits using ternary solutions of sodium chloride and sucrose 显示文摘 | Mayor L Moreira R Chenlo F | 2007 | Drying Technology : An International Journal2007，25，10： | 1 |
| 13 | Bovine somatotropin increase embryonic development in superovulated cows and improves post-transfer pregnancy rates when given to lactating recipient cows显示文摘 | Moreira F Badinga L Burnley C | 2002 | Theriogenology2002，57，： | 1 |
| 14 | Transparent thermally stable poly(etherimide) film as flexible substrate for OLEDs 显示文摘 | Calil V L Legnani C Moreira G F | 2009 | Thin Solid Films2009，518，5： | 1 |
| 15 | An overview of mannan structure and mannan-degrading enzyme systems显示文摘 | Moreira L R S Filho E X F | 2008 | Applied Microbiology Biotechnology2008，79，2： | 1 |
| 16 | Spaciated ambient carbonyls in Rio de Janeiro,Brazil显示文摘 | GROSJEAN D GROSJEAN E MOREIRA L F R | 2002 | Environmental Science and Technology2002，36，： | 1 |
| 17 | Homocysteine and outcome in young patients with acule coronary syndromes显示文摘 | Martin-Herrero F Marlin Moreiras J Pabon P | 2007 | Int J Cardiol2007，118，2： | 1 |
| 18 | New Processes for the Production of Solar-grade Polycrystalline Silicon:A Review显示文摘 | Braga A F B Moreira S P Zampieri P R | | 0，，： | 1 |
| 19 | Speciated ambient carbonyls inRio de Janeiro, Brazil 显示文摘 | Grosjean D Grosjean E Moreira L F | 2002 | Environ Sci Technol2002，36，： | 1 |
| 20 | Total concentration of uranium and thorium in some brazilian soils 显示文摘 | Perez D V Saldanha M F C Moreira J C | 1998 | Pesquisa Agropecuaria Brasileira ( Brazil )1998，33，8： | 1 |
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