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| 1 | Celiac disease serology in patients with different pretest probabilities: Is biopsy avoidable?显示文摘AIM: To establish the diagnostic performance of sev-eral serological tests, individually and in combination, for diagnosing celiac disease (CD) in patients with different pretest probabilities, and to explore potential se- rological algorithms to reduce the necessity for biopsy. METHODS: We prospectively performed duodenal biopsy and serology in 679 adults who had either high risk (n = 161) or low risk (n = 518) for CD. Blood samples were tested using six assays (enzyme-linked immunosorbent assay) that detected antibodies to tissue transglutaminase (tTG) and deamidated gliadin peptide (DGP). RESULTS: CD prevalence was 39.1% in the high-risk population and 3.3% in the low-risk group. In high-risk patients, all individual assays had a high diagnostic efficacy [area under receiving operator characteristic curves (AU ROC): 0.968 to 0.999]. In contrast, assays had a lower diagnostic efficacy (AU ROC: 0.835 to 0.972) in the low-risk group. Using assay combinations, it would be possible to reach or rule out diagnosis of CD without biopsy in 92% of cases in both pretest populations. We observed that the new DGP/tTG Screen assay resulted in a surplus compared to more conventional assays in any clinical situation. CONCLUSION: The DGP/tTG Screen assay could be considered as the best initial test for CD. Combinations of two tests, including a DGP/tTG Screen, might be able to diagnose CD accurately in different clinical scenarios making biopsy avoidable in a high proportion of subjects. | Emilia Sugai María L Moreno Hui J Hwang Ana Cabanne Adriana Crivelli Fabio Nach-man Horacio Vázquez Sonia Niveloni Julio Argonz Roberto Mazure Graciela La Motta María E Caniggia Edgardo Smecuol Néstor Chopita Juan C Gómez Eduardo Maurińo Julio C Bai | 2010 | World Journal of Gastroenterology2010，16，25： | 4 |
| 2 | Expression profiles of Dax1,Dmrt1,and Sox9 during temperature sex determination in gonads of the sea turtle Lepidochelys olivacea显示文摘 | Landa P A Moreno M N | 2002 | Genaral & Comparative Endocrinology2002，129，1： | 1 |
| 3 | Acute toxicity of LAS homologues in marine microalgae : esterase activity and inhibition growth as endpoints of toxicity 显示文摘 | HAMPEL M MORENO G I SOBRINO C | 2001 | Ecotoxicol Environ Safety2001，48，： | 1 |
| 4 | On the characterization of acidic and basic surface sites on carbons by various techniques显示文摘 | M V Lopez - ramon F Stoeckli C Moreno - castilla F C | 1999 | Carbon1999，37，： | 1 |
| 5 | Composition of human plaque fluid显示文摘 | MORENO E C MARGOLIS H C | 1988 | J Dent Res1988，67，9： | 1 |
| 6 | Functional as-sessment of perforin C2 domain mutations illustrates the critical role for calcium-dependent lipid binding in perforin cytotoxic func- tion显示文摘 | Urrea Moreno R Gil J Rodriguez-Sainz C | 2009 | Blood2009，113，2： | 1 |
| 7 | Polymorphiam in repeated 16S rRNA genes is a common property of type strains and environmental isolates of the genus V/br/o显示文摘 | Moreno C Romero J Romilio T E | 2002 | Microbiology2002，148，： | 1 |
| 8 | Usefulness of anorectal manometry in the neonatal diagnosis of Hirschsprung disease显示文摘 | Nunez R Cabrera R Moreno C | | 0，，01： | 1 |
| 9 | Tungsten and tungsten carbide supported on activated carbon: Surface structure and performance for ethylene hydrogenation显示文摘 | MORENO C C ALVAREZ M A CARRASCO M F FIERRO J L | 2001 | Langmuir2001，17，5： | 1 |
| 10 | Laparoscopic appendectomy during pregnancy: between personal experiences and scientific evidence显示文摘 | Moreno Sanz C Pascual-Pedreno A Picazo Yeste JS | 2007 | J Am Coll Surg2007，205，1： | 1 |
| 11 | Microbial corrosion of stainless steel显示文摘 | Ibars JR Moreno DA Ranninger C | 1992 | Microbiologia1992，8，2： | 1 |
| 12 | Picodetermination of microcystins in natural blooms and cyanobacterial strain cultures by matrix solid-phase disperseion and liquid chromatography-mass spectrometry显示文摘 | ANA C N ISABE M MORENO M A J | 2004 | Anal Bioanal Chem2004，380，： | 1 |
| 13 | Hemisection as an alterna-tive treatment for decayed multirooted terminal abutment: a case report 显示文摘 | Saad MN Moreno J Crawford C | 2009 | J Can Dent Assoc2009，75，5： | 1 |
| 14 | Pga26 mediates filamentationand biofilm formation and is required for virulence in Candidaalbicans 显示文摘 | Laforet L Moreno I Sanchez-Fresneda R Martinez-Esparza M Martinez J P Argiielles J C | 2011 | FEMS Yeast Res2011，11，： | 1 |
| 15 | Effect of temperature on the free radical scavenging ca- pacity of extracts from red and white grape pomace peel 显示文摘 | LARRAURI J A SANCHEZ - MORENO C SAURA - CALIXTO F | 1998 | J Agric Food Chem1998，46，7： | 1 |
| 16 | Power-electronic systems for the grid integration of renewable energy sources: A survey 显示文摘 | CARRASCO J M FRANQUELO L G BIALASIEWICZ J T GALVAN E GUISADO R C P PRATS M A M LEON J I MORENO N | 2006 | IEEE Transactions on Industrial Electronics2006，53，4： | 1 |
| 17 | Automated classification of short echo time in vivo lH brain tumour spectra;a multicentre study clinical application of proton magnetic显示文摘 | Tate AR Majos C Moreno A | | 0，，01： | 1 |
| 18 | Evolution of pH during in-situ leaching in small concrete cavities 显示文摘 | Sagues A A Moreno E I Andrade C | 1997 | Cement and Concrete Research1997，27，11： | 1 |
| 19 | Liquid Playgrounds显示文摘 | Moreno C D Grinda E G | 2003 | EL Croquis 121/1222003，，： | 1 |
| 20 | Controver- sies in the Current Manageas显示文摘 | Moreno Egea A Baena Enrique G Calle Miquel C | 2007 | Arch Surg2007，142，： | 1 |
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