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| 1 | Celiac disease serology in patients with different pretest probabilities: Is biopsy avoidable?显示文摘AIM: To establish the diagnostic performance of sev-eral serological tests, individually and in combination, for diagnosing celiac disease (CD) in patients with different pretest probabilities, and to explore potential se- rological algorithms to reduce the necessity for biopsy. METHODS: We prospectively performed duodenal biopsy and serology in 679 adults who had either high risk (n = 161) or low risk (n = 518) for CD. Blood samples were tested using six assays (enzyme-linked immunosorbent assay) that detected antibodies to tissue transglutaminase (tTG) and deamidated gliadin peptide (DGP). RESULTS: CD prevalence was 39.1% in the high-risk population and 3.3% in the low-risk group. In high-risk patients, all individual assays had a high diagnostic efficacy [area under receiving operator characteristic curves (AU ROC): 0.968 to 0.999]. In contrast, assays had a lower diagnostic efficacy (AU ROC: 0.835 to 0.972) in the low-risk group. Using assay combinations, it would be possible to reach or rule out diagnosis of CD without biopsy in 92% of cases in both pretest populations. We observed that the new DGP/tTG Screen assay resulted in a surplus compared to more conventional assays in any clinical situation. CONCLUSION: The DGP/tTG Screen assay could be considered as the best initial test for CD. Combinations of two tests, including a DGP/tTG Screen, might be able to diagnose CD accurately in different clinical scenarios making biopsy avoidable in a high proportion of subjects. | Emilia Sugai María L Moreno Hui J Hwang Ana Cabanne Adriana Crivelli Fabio Nach-man Horacio Vázquez Sonia Niveloni Julio Argonz Roberto Mazure Graciela La Motta María E Caniggia Edgardo Smecuol Néstor Chopita Juan C Gómez Eduardo Maurińo Julio C Bai | 2010 | World Journal of Gastroenterology2010，16，25： | 4 |
| 2 | Determination of eight water- and fat-soluble vitamins in multi-vitamin pharmaceutical formulations by high-performance liquid chromatography显示文摘 | P Moreno V Salvadó | 2000 | Journal of Chromatography A2000，，1： | 2 |
| 3 | Uterine factors and risk of pregnancy in IUD users: a nested case-control study显示文摘 | àngels Avecilla-Palau Víctor Moreno | 2003 | Contraception2003，，3： | 2 |
| 4 | Complex networks:structure and dynamics显示文摘 | Boccaletti S Latora V Moreno Y | 2006 | Physics Reports2006，424，45： | 1 |
| 5 | On the characterization of acidic and basic surface sites on carbons by various techniques显示文摘 | M V Lopez - ramon F Stoeckli C Moreno - castilla F C | 1999 | Carbon1999，37，： | 1 |
| 6 | Complex networks: structure and dynamics显示文摘 | BOCCALETTI S LATORA V MORENO Y | 2006 | Physics Reports2006，424，45： | 1 |
| 7 | Complex Networks:Structure and Dynamics显示文摘 | BOCCALETTI S LATORA V MORENO Y | 2006 | Phys Rep2006，81，3： | 1 |
| 8 | Effect of long-term corona on non-ceramic outdoor insulator housing materials显示文摘 | Moreno V M Gorur R S | 2001 | IEEE Transactions on Dielec- trics and Electrical Insulation2001，1，8： | 1 |
| 9 | Effect of oral contraceptives on risk of cervical cancer in women with human papillomavirus infection: the 1ARC multicentric case-control study 显示文摘 | Moreno V Bosch FX Munoz N | 2002 | Lancet2002，359，： | 1 |
| 10 | AC and DC performance of polymer-ic housing materials for HV outdoors insulators显示文摘 | Moreno V M Gorur R S | 1999 | IEEE Transactions on Dielectrics and Electrical Insulation1999，6，3： | 1 |
| 11 | Complex net-works:structure and dynamics显示文摘 | Boccaletti S Latora V Moreno Y | 2006 | Physics Reports2006，424，45： | 1 |
| 12 | Intimomedial interface damage and adventitial inflammation is increased beneath disrupted atherosclerosis in the aorta: implications for plaque vulnerability 显示文摘 | Moreno P R Purushothaman K R Fuster V | 2002 | Circulation2002，105，21： | 1 |
| 13 | Age differences in memory control: Evi- dence from updating and retrieval practice tasks 显示文摘 | LECHUGA M T MORENO V PELEGRINA S | 2006 | Acta Psychological2006，123，： | 1 |
| 14 | Atherothrombosis and high-risk plaque: part I: evolving concepts 显示文摘 | Fuster V Moreno PR Fayad ZA | 2005 | J Am Coil Car- dio12005，46，： | 1 |
| 15 | Complex net- works: structure and dynamics 显示文摘 | Boccaletti S Latora V Moreno Y | 2006 | Physics Reports2006，424，4： | 1 |
| 16 | Complex networks: Structure and dynamics显示文摘 | Boccaletti S Latora V Moreno Y | 2006 | Physics Reports2006，424，17： | 1 |
| 17 | Complex networks:structure and dynamics显示文摘 | Latora V Moreno Y | 2006 | Physics Reports2006，424，： | 1 |
| 18 | Atherothrombosis as a systemic,often silent,disease显示文摘 | Fuster V Moreno PR | 2005 | Nat Clin Pract Cardiovasc Med2005，2，9： | 1 |
| 19 | Complex networks: structure and dynamics 显示文摘 | BOCCALETTI S LATORA V MORENO Y | 2006 | Physics Reports2006，424，45： | 1 |
| 20 | Effect of long-term corona on non-ce-ramic outdoor insulator housing materials显示文摘 | Moreno V M Gorur R S | 2001 | IEEE Transactions on Dielectrics and Electrical Insulation2001，8，1： | 1 |
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