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| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | 葡糖胺和半乳糖胺的测定显示文摘定量测定葡糖胺和半乳糖胺的分析操作已由Elson和Morgan(1933)报道[1]。这一方法基于Pauly和Ludwig(1922)的发现,即在100℃的碱性溶液中氨基糖与乙酰丙酮反应形成一生色物质,这一物质经对二甲氨基苯甲醛酸性乙醇溶液处理产生一个或多个发色团。光电分光光度计的开发和应用很大程度上提高了技术灵敏度和准确度,虽然已报道了很多此方法的改良设计操作。 | Rondle C J M Morgan W T J 陈祥娥 | 2010 | 食品与药品2010，12，11： | 2 |
| 3 | The crystal structure of an odorant binding protein from Anopheles gambiae: evidence for a common ligand release mechanism 显示文摘 | Wogulis M Morgan T Ishida Y | 2006 | Biochem Biophys Res Commun2006，339，1： | 1 |
| 4 | The crystal structure of an odorant binding protein from Anopheles gambiae : Evidence for a common ligand release mechanism显示文摘 | Wogulis M Morgan T Ishida Y | 2006 | Biochemical and Bio- physical Research Communications2006，339，： | 1 |
| 5 | Conversion of triglycerides to hydrocarbons over supported metal catalysts 显示文摘 | MORGAN T GRUBB D SANTILLAN-JIMENEZ E CROCKER M | 2010 | Top Catal2010，53，1112： | 1 |
| 6 | Germline mutations in WTX cause a sclerosing skeletal dysplasia but do not predispose to tumorigenesis显示文摘 | Jenkins ZA van Kogelenberg M Morgan T | 2009 | Nature Genetics2009，41，1： | 1 |
| 7 | Assessment of erosion hazard with the USLE and GIS:a case study of the upper Ewaso Ng'iro North Basin of Kenya显示文摘 | Mati B M Morgan R P C Gichuki F N Quinton J N Brewer T R Liniger H P | | 0，，02： | 1 |
| 8 | A trypsin-solubilized laccase from pharate pupal integument of the tobacco homworm, Manduca sexta 显示文摘 | Thomas B R Yonekura M Morgan T D | 1989 | Insect Biochem1989，19，7： | 1 |
| 9 | Retention of oncogenicity by a Marek's disease virus mutant lacking six unique short region genes 显示文摘 | Parcells M S Anderson A S Morgan T W | 1995 | J Virol1995，69，： | 1 |
| 10 | Transdermal penetration enhancers:applications,limitations,and potential显示文摘 | Finnin B C Morgan T M | 1999 | J Pharm Sci1999，88，： | 1 |
| 11 | Sustained secretion of human alpha-1-antitrypsin from murine muscle transduced with adeno-associated virus vectors显示文摘 | Song S Morgan M Ellis T | 1998 | Proc Nail Acad Sci USA1998，95，14： | 1 |
| 12 | Angiotensinogen Thr235 variant is associated with abnormal physiologic change of the uterine spiral afteries in first-trimester decidua显示文摘 | MORGAN T CRAVEN C LALOUEL J M | 1999 | Am J Obstet Gynecol1999，180，11： | 1 |
| 13 | Preliminary findings of the minimally-invasive surgery plus rtPA for intracerebral hemorrhage evacuation clinical trial显示文摘 | Morgan T Zuccarello M Narayan R | 2008 | Acta Neurochir Suppl2008，105，5： | 1 |
| 14 | Germline mutations in WTX cause a sclerasing skeletal dysplasia but do not predispose to tumorigenesis显示文摘 | Jenkins ZA ' 'an Kogelenberg M Morgan T | 2009 | Nat Genet2009，41，1： | 1 |
| 15 | Leaf and fruit mineral content and peel thickness of ' Hamlin' or- ange 显示文摘 | Morgan K T Rouse R E Roka F M | 2005 | Processing of Florida State Horticultural Society2005，118，： | 1 |
| 16 | Synergistic enhancement of testosterone transdermal delivery显示文摘 | Nicolazzo J A Morgan T M Reed B L | 2005 | J Cont Rel2005，103，3： | 1 |
| 17 | Soy isoflavones improve cardiovascular risk factors without affecting the reproductive system of peripubertal rhesus monkeys显示文摘 | Anthony M S Clarkson T B Hughes C L J Morgan T M Burke GL | 1996 | J Nutr1996，126，1： | 1 |
| 18 | Note: tree ring respon- ses to drought across species and contrasting sites in the ridge and valley of central Pennsylvania 显示文摘 | Abrams M D Ruffner C M Morgan T A | 1998 | Forest Science1998，44，4： | 1 |
| 19 | Tales from the fields:sources of employee identification in agribusiness显示文摘 | Morgan J M Reynolds C M Nelson T J Johanningmeier A R Griffin M Andrade P | | 0，，02： | 1 |
| 20 | Targeted therapy for ad- vanced prostate cancer: inhibition of the PI3K/AKT/mTOR path- way 显示文摘 | Morgan T M Koreckij T D Corey E | 2009 | Curr Cancer Drug Targets2009，9，2： | 1 |
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