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| 1 | Correlation of N-myc downstream-regulated gene 1 expression with clinical outcomes of colorectal cancer patients of different race/ethnicity显示文摘AIM: To evaluate the role of N-myc downstream-regulated gene 1 (NDRG1) expression in prognosis and survival of colorectal cancer patients with different ethnic backgrounds. METHODS: Because NDRG1 is a downstream target of p53 and hypoxia inducible factor-1α (HIF-1α),we examined NDRG1 expression together with p53 and HIF-1α by immunohistochemistry. A total of 157 colorectal cancer specimens including 80 from Japanese patients and 77 from US patients were examined. The correlation between protein expression with clinicopathological features and survival after surgery was analyzed.in colorectal tumor compared with normal epithelium in both Japanese and US patient groups. Expression of NDRG1 protein was significantly correlated with lymphatic invasion,venous invasion,depth of invasion,histopathological type,and Dukes' stage in Japanese colorectal cancer patients. NDRG1 expression was correlated to histopathological type,Dukes' stage and HIF-1α expression in US-Caucasian patients but not in US-African American patients. Interestingly,Kaplan-Meier survival analysis demonstrated that NDRG1 expression correlated significantly with poorer survival in US-African American patients but not in other patient groups. However,in p53-positive US cases,NDRG1 positivity correlated significantly with better survival. In addition,NDRG1 expression also correlated significantly with improved survival in US patients with stages Ⅲ and Ⅳ tumors without chemotherapy. In Japanese patients with stages Ⅱ and Ⅲ tumors,strong NDRG1 staining in p53-positive tumors correlated significantly with improved survival but negatively in patients without chemotherapy. CONCLUSION: NDRG1 expression was correlated with various clinicopathological features and clinical outcomes in colorectal cancer depending on the race/ethnicity of the patients. NDRG1 may serve as a biological basis for the disparity of clinical outcomes of colorectal cancer patients with different ethnic backgrounds. | Minori Koshiji Kensuke Kumamoto Keiichirou Morimura Yasufumi Utsumi Michiko Aizawa Masami Hoshino Shinji Ohki Seiichi Takenoshita Max Costa Thérèse Commes David Piquemal Curtis C Harris Kam-Meng Tchou-Wong | 2007 | World Journal of Gastroenterology2007，13，20： | 25 |
| 2 | Factors controlling the ionic mobility of lithium electrolyte solutions in separator membranes显示文摘 | SAITO Y MORIMURA W KURATANI R | 2016 | Journal of Physical Chemistry C2016，120，7： | 1 |
| 3 | Novel diagnostic value of circulating miR-18a in plasma of patients with pancreatic cancer显示文摘 | Morimura R Komatsu S Ichikawa D | | 0，，11： | 1 |
| 4 | Cell cycle arrest and apoptosis induced by Notch1 in B cells显示文摘 | Morimura T Goitsuka R Zhang Y | 2000 | J Biol Chem2000，275，36： | 1 |
| 5 | yon Wille- brand factor in cadaveric urine for forensic investiga- tion显示文摘 | Kasuda S Kudo R Morimura Y | 2009 | Leg Med(Tokyo)2009，11，5： | 1 |
| 6 | Degradation and behavior of natural steroid hormones in cow manure waste during biological treatments and ozone oxidation 显示文摘 | ERMAWATI R MORIMURA S TANG Y Q | 2007 | Biosei Bioeng2007，103，1： | 1 |
| 7 | Peroxisome proliferator activated receptor γ in colonic epithelial cells protects against experimental inflammatory bowel disease显示文摘 | Adachi M Kurotani R Morimura K | 2006 | Gut2006，55，8： | 1 |
| 8 | Peroxisome proliferator activatedreceptor gamma in colonic epithelial cells protects against experimental inflammatory bowel disease显示文摘 | Adachi M Kurotani R Morimura K | 2006 | Gut2006，55，10： | 1 |
| 9 | Peroxisome proliferator activated receptor gamma in colonic epithelial cells protects against experimental inflammatory bowel disease显示文摘 | Adachi M Kurotani R Morimura K | 2006 | Gut2006，55，8： | 1 |
| 10 | Novel diagnostic value of circulating miR-18a in plasma of patients with pancreatic cancer显示文摘 | Morimura R Komatsu S lchikawa D | 2011 | Br J Cancer2011，105，11： | 1 |
| 11 | Novel diagnostic value of circulating mi R-18a in plasma of patients with pancreatic cancer显示文摘 | Morimura R Komatsu S Ichikawa D | 2011 | Br J Cancer2011，105，11： | 1 |
| 12 | Novel diagnostic value of circulating miR-18a in plasma of patients with pancreatic cancer显示文摘 | MORIMURA R KOMATSU S ICHIKAWA D | 2011 | Brj Cancer2011，105，11： | 1 |
| 13 | Novel diagnostic value of circulating miR-18a in plasma of patients with pancreatic cancer显示文摘 | Morimura R Komatsu S Ichikawa D | | 0，，11： | 1 |
| 14 | Peroxisome proliferator activated receptor gamma in colonic epithelial cells protects against experimental inflammatory bowel disease 显示文摘 | Adachi M Kurotani R Morimura K | 2006 | Gut2006，55，8： | 1 |
| 15 | Cell cycle arrest and apoptosis induced by Notch1 in B cells显示文摘 | MORIMURA T GOITSUKA R ZHANG Y | 2000 | J Biol Chem2000，275，36： | 1 |
| 16 | Novel diagnostic value of circulating miR-18a in plasma of patients with pancreatic cancer显示文摘 | Morimura R Komatsu S Ichikawa D | 2011 | Br J Cancer2011，105，11： | 1 |
| 17 | Novel diagnostic value ofcirculating miR-18a in plasma of patients with pancreatic cancer 显示文摘 | Morimura R Komatsu S Ichikawa D | 2011 | BrJ Cancer2011，105，11： | 1 |
| 18 | PPARγ in colonic epithelial cells protects against experimental inflammatory bowel disease显示文摘 | ADACHI M KUROTANI R MORIMURA K | 2006 | Gut2006，55，8： | 1 |
| 19 | Novel diagnostic value of circulating miR-18a in plasma of patients with pancreatic cancer显示文摘 | Morimura R Komatsu S Ichikawa D | 2011 | Br J Cancer2011，105，11： | 1 |
| 20 | Novel diagnostic value of circulating miR-18a in plasma of patients with pancreatic cancer显示文摘 | Morimura R Komatsu S Ichikawa D | 2011 | BrJ Cancer2011，105，11： | 1 |
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