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| 1 | Combined carriership of TLR9 -1237C and CD14 -260T alleles enhances the risk of developing chronic relapsing pouchitis显示文摘AIM: To investigate the single nucleotide polymorphisms (SNPs) in genes involved in bacterial recognition and the susceptibility to pouchitis or pouchitis severity.METHODS: Analyses of CD14 -260C>T, CARD15/NOD2 3020insC, Toll-like receptor (TLR)4 +896A>G,TLR9 -1237T>C, TLR9+ 2848G>A, and IRAKM +22148G>A SNPs were performed in 157 ileal-pouch anal anastomosis (IPAA) patients (79 patients who did not develop pouchitis, 43 infrequent pouchitis patients,35 chronic relapsing pouchitis patients) and 224 Italian Caucasian healthy controls.RESULTS: No significant differences were found in SNP frequencies between controls and IPAA patients.However, a significant difference in carriership frequency of the TLR9-1237C allele was found between the infrequent pouchitis and chronic relapsing pouchitis groups [P = 0.028, odd's ratio (OR) = 3.2, 95%CI = 1.2-8.6].This allele uniquely represented a 4-locus TLR9 haplotype comprising both studied TLR9 SNPs in Caucasians.Carrier trait analysis revealed an enhanced combined carriership of the alleles TLR9 -1237C and CD14 -260T in the chronic relapsing pouchitis and infrequent pouchitis group (P = 0.018, OR = 4.1, 95%CI = 1.4 -12.3).CONCLUSION: There is no evidence that the SNPs predispose to the need for IPAA surgery. The significant increase of the combined carriership of the CD14 -260T and TLR9 -1237C alleles in the chronic relapsing pouchitis group suggests that these markers identify a subgroup of IPAA patients with a risk of developing chronic or refractory pouchitis. | KM Lammers S Ouburg SA Morré JBA Crusius P Gionchetti F Rizzello C Morselli E Caramelli R Conte G Poggioli M Campieri AS Pea | 2005 | World Journal of Gastroenterology2005，11，46： | 7 |
| 2 | Regulation of weibel- patade body exocytosis显示文摘 | Lowenstein CJ Morreli CN Yamakuchi M | 2005 | Semin Vasc Med2005，15，8： | 1 |
| 3 | Acquired homotypic and heterotypic immunity against oculogenital Chlamydia trachomatis serovars following female genital tract infection in mice显示文摘 | Lyons J M Morre SA Airo-Brown lP | 2005 | BMC Infect Dis2005，5，： | 1 |
| 4 | Triuret:a novel product of peroxynitrite-mediated oxidation of urate显示文摘 | Robinson K M Morre J T Beckman J S | 2004 | Arch Biochem Biophys2004，423，1： | 1 |
| 5 | CD14 and TLR4 gene polymorphisms in adult periodontitis 显示文摘 | LAINE M L MORRE S A MURILLO L S | 2005 | Dent Res2005，84，11： | 1 |
| 6 | Expression of IL-7 receptor α is necessary but not sufficient for the formation of memory CD8 T cells during viral infection 显示文摘 | Hand TW Morre M Kaech SM | 2007 | Proc Natl Acad Sci USA2007，104，11： | 1 |
| 7 | Red imported ftre ant control with diazinon and chlorpyrifos drenches显示文摘 | Morr L B M | 1977 | J Georgia Entomol Soc1977，12，： | 1 |
| 8 | GGDEF and EAL domains inversely regulate cyclic di- GMP levels and transition from sessility to motili- ty显示文摘 | SIMM R MORR M KADER A | 2004 | Mol Microbiol2004，53，4： | 1 |
| 9 | Relationship of metal metabolism to vascular disease morality rates in Texas显示文摘 | DAWSON E B FREY M J MORRE T D | 1978 | The Ameri- can Journal of Clinical Nutrition1978，31，： | 1 |
| 10 | Minimax and maxmin distance design显示文摘 | JOHNSON M E MORRE L M VLVISAKER D | 1990 | Journal of Statistical Planning and Inference1990，，26： | 1 |
| 11 | Regulation of weibel-palade body exocytosis显示文摘 | Lowenstein CJ Morreli CN Yamakuchi M | 2005 | Senun Vase Med2005，15，8： | 1 |
| 12 | Correlation betweencerebral blood volume values and outcomes in eudovascular therapy for acute ischemic stroke 显示文摘 | Mokin M Morr S Fanous AA | 2015 | J Neurointerv Surg2015，7，10： | 1 |
| 13 | Aqueous two-phase partition applied to the isolation of plasma membrane and Golgi apparatus from cultured mammalian cells 显示文摘 | Dorothy M M Morre D J | 2000 | J Chromatogr B2000，，742： | 1 |
| 14 | Self-regulated alternative splicing at the AHNAK locus显示文摘 | de Morrée A Droog M Grand Moursel L | | 0，，01： | 1 |
| 15 | On Looking into the Black Box: Prospects and Limits in the Search for Mental Models 显示文摘 | WILLIAM B ROUSE NANCY M MORR/SS | 1986 | Psychological Bulletin 1001986，，： | 1 |
| 16 | Iadsa with isotonic dimeric(Visipaque)and monomeric(inhexol)non-ionic contrastmedia;radiographic,clinical and neurophysiologiacal evaluation显示文摘 | Hekster R E M Morr H H E Cleynder P | 1995 | Neu roradiology1995，37，： | 1 |
| 17 | The cytology and cytochemostry of the hemocytes of Mytilus edulis and their response to experimentally injected carbon particles显示文摘 | Morre M N Lowe D W | 1977 | J Invertebr Pathol1977，29，1： | 1 |
| 18 | In-situ ozonation of contaminated groundwater显示文摘 | Nimmer M A Wayner B D Morr A A | 2000 | Environ Prog2000，19，3： | 1 |
| 19 | Thermotropic and lyotropic properties of long chain alkyl glycopyranosides: Part IlL pH-sensitive headgroups显示文摘 | Milkereit G Morr M Thiem J etal | 2004 | Chemistry and Physics of Lipids2004，127，1： | 1 |
| 20 | CD14 and TLR4 Gene polymorphisms in adult periodontitis显示文摘 | Laine M L Morre S A Murillo L S | 2005 | J Dent Res2005，84，11： | 1 |
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