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| 1 | Science:'记忆碎片'是真的吗?显示文摘半个多世纪以来,神经学家们一直以为长期记忆是由于多个短期记忆储存起来形成的。而最近一项对记忆形成的神经回路的研究则表明这一说法有可能是错的,因为两种类型的记忆(长期与短期)能够同时产生。这项研究是由来自MIT的研究者们做出。他们参考了此前标记特殊”记忆”细胞的手段,并更进一步地强制性使小鼠对特定的记忆作出反应。并且断开了长期与短期记忆的连接。 | Takashi Kitamura Mark D. Morrissey Lillian M. Smith Roger L. Redondo | 2017 | 现代生物医学进展2017,17,17: | 11 |
| 2 | 发展中国家糖尿病的患病率差异比较及其与体质量和初级卫生保健的关系研究显示文摘目的利用世界卫生组织调查的数据,分析49个发展中国家糖尿病的患病率变化及其与体质量和初级卫生保健之间的联系。方法本研究中,糖尿病的界定是利用内科医生关于糖尿病诊断的个体报告;体质量指数(BMI)的计算是体质量(Kg)与身高平方(m2)的比值;治疗状态是评估是否获得卫生保健支持临床治疗以及糖尿病病人是否遵医并有行为改变;糖尿病和BMI以及治疗状态的关联使用横断面分析。结果共纳入215 898位个体进行研究。糖尿病年龄调整患病率范围从0.27%(马里)到15.54%(毛里求斯)。低体质量人群(BMI<18.5kg/m2),超体质量人群(BMI 25~29.9kg/m2)以及肥胖人群(BMI≥30kg/m2)患糖尿病的风险与正常体质量人群(BMI 18.5~24.9kg/m2)相比,差异具有统计学意义,多因素校正的OR值(95%CI)分别为1.15(1.07~1.24),1.56(1.44~1.68)和2.38(2.17~2.61)。所有纳入研究者中糖尿病患者的未治疗率为9.6%,低体质量患者的未治疗率最高,依次为正常体质量患者、超体质量患者、肥胖患者。结论在中低收入国家中,糖尿病的患病率变化以及糖尿病的初级卫生保健支持度的变化具有统计学意义。积极地预防人群超体质量和提高卫生保健支持度对于在发展中国家改善糖尿病的高流行可以发挥非常重要作用。 | 刘隆健 杨晓虹 殷晓燕 Susan Morrissey 邹强 杨书 李茂全 陈卫中 | 2013 | 成都医学院学报2013,8,2: | 4 |
| 3 | 一例中国人FV Leiden基因突变家系报告(英文)显示文摘目的 研究中国人FVLeiden基因突变引起的抗活化蛋白C现象 (APCR)。方法 采用APTT±APC方法、多聚酶链反应 (PCR)、MnLI限制性内切酶分析 ,序列特异性引物 (PCR SSP)和DNA测序方法 ,对中国汉族 30例“正常”无关个体和 2 0例血栓性疾病患者进行APCR测定和FVLeiden基因突变分析。结果 发现一例正常人抗APC敏感值比值 (APC SR)明显减低 (0 8) ,并确诊为FVLeiden基因 (Arg50 6 Gln)突变杂合子 ,其叔祖父、父亲、弟弟和儿子同样确定为FVLeiden基因杂合子 ;有 3例血栓性疾病患者APC SR低于正常 ,但均无FVLeiden基因突变。结论 这是在国内发现的首例四代FVLeiden突变所致的APCR现象的家系。中国人血栓症中APCR的产生是否导致其它未知的基因缺陷 ,尚待进一步研究。 | 吴竞生 顾建民 徐俊 汪健 孙自敏 MD Smirnov JH Morrissey N Esmon | 2001 | Chinese Medical Journal2001,,4: | 3 |
| 4 | Identifying Important Predictors for Anastomotic Leak After Colon and Rectal Resection: Prospective Study on 616 Patients显示文摘 | Koianka Trencheva Kevin P. Morrissey Martin Wells Carol A. Mancuso Sang W. Lee Toyooki Sonoda Fabrizio Michelassi Mary E. Charlson Jeffrey W. Milsom | 2013 | Annals of Surgery2013,,1: | 2 |
| 5 | Mismatch repair enzyme expression in primary and castrate resistant prostate cancer显示文摘Objective:Although the utility of immunohistochemistry(IHC)for assessing mismatch repair(MMR)protein expression has been demonstrated in solid tumors including primary prostate cancer(PCa),its utility has not been assessed in castration-resistant PCa(CRPC).Methods:Tissue microarrays were constructed from 127 radical prostatectomies and 155 CRPC metastases from 50 patients.MMR(MLH1,MSH2,MSH6,and PMS2)expression was assessed by IHC and gene expression arrays.Associations between MMR protein expression in PCa and CRPC and biochemical recurrence(BCR)or time from diagnosis to death respectively were determined.Results:There was no correlation between levels of MMR protein and BCR.Absence of MSH2 and MSH6 was the most pronounced at 15%and 22%in PCa and 17.8%and 16%in CRPC patients,respectively.MSH2 and MSH6 protein were absent in 9.4%and 8%of PCa and CRPC respectively.Absence of individual MMR proteins did not correlate with BCR or time from diagnosis to death.However absent MSH2/MSH6 in CRPC was associated with shorter time to death(pZ0.0006).Loss of MSH2 was verified at the gene expression level.This finding correlated with microsatellite instability previously reported in this CRPC cohort. | Belinda Nghiem Xiaotun Zhang Hung-Ming Lam Lawrence DTrue Ilsa Coleman Celestia SHigano Peter SNelson Colin CPritchard Colm Morrissey | 2016 | Asian Journal of Urology2016,3,4: | 2 |
| 6 | 去家庭化与再家庭化——中英两国青年“六个钱包买房”的比较显示文摘随着“六个钱包买房”现象在国内外日益普遍,引发了代际支持购房形塑代际关系,影响经济和社会变迁的争论。结合由争论产生的“去家庭化”和“再家庭化”视角,围绕代际契约研究框架,通过对中英两国青年22次访谈的比较,从青年视角探讨了代际支持购房与代际关系变化的联系。结果发现,中国青年在代际支持的方向性、持续性和影响性上展现出更强的再家庭化趋势。而差异的原因在于:中国青年在个体层面上家庭支持来源较单一,受支持程度较强,理解支持更动态;结构层面上面临更大市场压力,较缺乏政策支持,阶层认同较模糊,更具家庭主义传统。据此,政府应结合建设住房调控长效机制和解决青年住房问题的视角提出政策。 | 聂晨 Paul Morrissey | 2020 | 当代青年研究2020,,4: | 2 |
| 7 | 在iPhone上的品牌推广胜败战显示文摘iPhone是数字时代的文化符号,它的广告语“总有一款应用程序适合你”,巧妙地点出了这款“耶稣般万能”手机平台的特点。 | Brian Morrissey 杨丽媛 | 2010 | 成功营销2010,,1: | 2 |
| 8 | Angiotensin Ⅱ receptor antagonist ameliorates renal tubulointerstitial fibrosis caused by unilateral ureteral obstruction显示文摘 | Ishidoya S Morrissey I Mccracker R | 1995 | Kidney Iht1995,47,5: | 2 |
| 9 | Obstructive nephropathy and renal fibrosis显示文摘 | Klahr S Morrissey J | 2002 | Am J Physiol Renal Physiol2002,283,5: | 1 |
| 10 | Influence of dietary a-tocopherol on tocopherol concentrations in chick tissues显示文摘 | Sheehy J A Morrissey P A Flynn A | 1991 | British Poultry Science1991,32,2: | 1 |
| 11 | Complement-induced endothelial dysfunction in rabbits: mechanism, recovery, and gender differences显示文摘 | Lennon PF Collard CD Morrissey MA | 1996 | Am J Physiol1996,270,62: | 1 |
| 12 | Gelation of surimi by high hydrostatic pressure显示文摘 | Chung Y C Gebrehiwot A Farkas D F Morrissey M T | 1994 | J Food Sci1994,59,52: | 1 |
| 13 | Molecular cloning and biological characterization of a novel murine lymphoid growth factor显示文摘 | Sims J E Williams D E Morrissey P J | 2000 | J Exp Med2000,192,: | 1 |
| 14 | Obstructive nephropathy and renal fibrosis显示文摘 | Klahr S Morrissey J | 2002 | Am J Physiol Renal Physiol2002,283,5: | 1 |
| 15 | Role of angiotensin II in the tubulointerstitial fibrosis of obstructive nephropathy显示文摘 | Klahr S Ishidoya S Morrissey J | 1995 | Am J Kidney Dis1995,26,1: | 1 |
| 16 | Statin therapy in patients with dias- tolic heart failure显示文摘 | Tehrani F Morrissey R Phau A | 2010 | Clin Cardiol2010,33,4: | 1 |
| 17 | Surirni gel enhancement by bovine plasma proteins显示文摘 | SEYMOUR T A PETERS M Y MORRISSEY M T | 1997 | Journal of Agricultural and Food Chemistry1997,45,8: | 1 |
| 18 | Combination therapy with an angiotensin-converting enzyme inhibitor and a vitamin D analog suppresses the progression of renal insufficiency in uremic rats显示文摘 | Mizobuchi M Morrissey J Finch JL | 2007 | J Am Soc Nephrol2007,18,6: | 1 |
| 19 | Complete sequence of the human tissue factor gene, a highly regulated cellular receptor that initiates the coagulation protease cascade 显示文摘 | Mackman N Morrissey JH Fowler B | 1989 | Biochemistry1989,28,4: | 1 |
| 20 | Effect of AT2 receptor blockade on the pathogenesis of renal fibrosis显示文摘 | Morrissey J J and Klahr S | 1999 | Am J Physiol1999,276,1: | 1 |