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| 1 | The combination of baicalin and baicalein enhances apoptosis via the ERK/p38 MAPK pathway in human breast cancer cells显示文摘 | Qian-mei ZHOU Song WANG Hui ZHANG Yi-yu LU Xiu-feng WANG Yoshiharu MOTOO Shi-bing SU | 2009 | Acta Pharmacologica Sinica2009，30，12： | 25 |
| 2 | Pancreatitis-associated protein:From a lectin to an anti-inflammatory cytokine显示文摘Pancreatitis-associated protein (PAP) was discovered in the pancreatic juice of rats with acute pancreatitis. PAP is a 16 kDa secretory protein structurally related to the C-type lectins although classical lectin-related function has not been reported yet. Then, it was demonstrated that PAP expression may be activated in some tissues in a constitutive or injury- and inflammation-induced manner. More recently, it has been found that PAP acts as an anti-inflammatory factor in vitro and in vivo. PAP expression can be induced by several pro- and anti-inflammatory cytokines and by itself through a JAK/STAT3-dependent pathway. PAP is able to activate the expression of the anti-inflammatory factor SOCS3 through the JAK/STAT3-dependent pathway. The JAK/STAT3/SOCS3 pathway seems to be a common point between PAP and several cytokines. Therefore, it is reasonable to propose that PAP is a new anti- inflammatory cytokine. | Daniel Closa Yoshiharu Motoo Juan L Iovanna | 2007 | World Journal of Gastroenterology2007，13，2： | 6 |
| 3 | 拉丝模参数对棒材拉拔后残余应力的影响显示文摘 | Motoo Asakawa Wataru Sasaki Shunsuke Shishido 孙刘歌 | 2004 | 金属制品2004，30，B05： | 5 |
| 4 | Experimental Studies on Thermal and Electrical Properties of Platinum Nanofilms显示文摘我们试验性地在 15nm 的厚度学习了热的在里面飞机和推迟的铂 nanofilm 的电的性质。测量结果证明 in-planethermal 传导性,电的传导性和学习 nanofilm 的抵抗温度系数多不到那些体积材料,当 Lorenz 数字比体积大时,珍视。与结果作比较在 28nm 的厚度为铂 nanofilm 以前报导了,我们进一步发现在里面飞机热电导率,电的传导性和抵抗温度系数与 nanofilm 的减少的厚度减少,当 Lorenz 数字与 nanofilm 的减少的厚度增加时。Theseresults 显示强壮的尺寸效果在在里面飞机上存在铂 nanofilms 的热、电的性质。 | 张兴 张清光 曹炳阳 FUJII Motoo TAKAHASHI Koji IKUTA Tatsuya | 2006 | Chinese Physics Letters2006，23，4： | 5 |
| 5 | Effect of Saikokeishito, a Kampo medicine, on hydrogen peroxide-induced premature senescence of normal human dermal fibroblasts显示文摘OBJECTIVE: Saikokeishito(TJ-10) is a Kampo(traditional Japanese herbal) medicine, clinically used for hundreds of years in East Asia. Among its various mechanisms elucidated so far, TJ-10 inhibits the production of transforming growth factor-β1(TGF-β1) and development of pancreatic fi brosis in vivo. Oxidative damage of normal human dermal fi broblasts(NHDFs) in the corium is a cause of human dermal senescence. Our aim was to determine whether TJ-10 protects NHDFs from premature senescence by hydrogen peroxide(H2O2). METHODS: Premature senescence was induced in NHDFs by 200 μmol/L H2O2 for 4 h. Cell viability and the expressions of p53, AMP-activated protein kinase α1(AMPKα1), AMPKα2, and 14-3-3 protein sigma(14-3-3 σ) were measured in NHDFs treated with TJ-10 for 48 h before exposure to H2O2 for 4 h. RESULTS: Cell viability after treatment with 200 μmol/L H2O2 for 4 h was similar(about 80%) to after pre-treatment with TJ-10. Ascorbic acid as a control did not protect NHDFs from damage by 200 μmol/L H2O2. Treatment with 200 μmol/L H2O2 tended to up-regulate p53 and to down-regulate SIRT1 and AMPKα1, but had no effect on AMPKα2 and 14-3-3 σ expression. Pretreatment with TJ-10 inhibited H2O2-induced up-regulation of p53 and enhanced AMPKα1 expression. CONCLUSION: It is suggested that Saikokeishito has a protective effect on oxidative stressinduced senescence of NHDFs. | Takanobu Takata Yoshiharu Motoo Naohisa Tomosugi | 2014 | Journal of Integrative Medicine2014，12，6： | 4 |
| 6 | Acupuncture improved lipid metabolism by regulating intestinal absorption in mice显示文摘BACKGROUND Non-alcoholic fatty liver disease(NAFLD),in which abnormal lipid metabolism plays an important role in disease progression,has become a pandemic.Abnormal lipid metabolism,for example an increased fat intake,has been thought to be an initial factor leading to NAFLD.The small intestine is the main site of dietary lipid absorption.A number of clinical trials have shown that acupuncture has positive effects in the regulation of lipid metabolism,which is closely associated with the progression of NAFLD.We therefore hypothesized that,acupuncture can improve the conditions of NAFLD by regulating intestinal absorption of lipid.AIM To study the role of acupuncture treatment in the improvement of metabolic syndrome secondary to NAFLD by mouse model.METHODS 8-wk-old male C57BL/6J mice were fed a methionine-and choline-deficient diet for 3 wk.Then,all mice were separated randomly into acupoints group(AG)or non-acupoints group(NG)with high fat diet feeding.Needling treatment was performed at Zu san li,Guan yuan and Yong quan acupoints as acupuncture treatment to AG mice while non-acupoints place to NG mice.Finally,mice were anesthetized with an injection of ketamine-medetomidine and euthanized by exsanguination.RESULTS An apparent improvement of obesity was found in AG mice after acupuncture treatment.In AG mice,the body weight was much lower(22.6±1.2 g vs 28.1±1.0 g,P<0.005)in comparison to NG mice.The length of small intestine in AG mice was significantly shorter(26.7±2.3 cm vs 32.7±2.7 cm,P<0.005).A large amount of chyme was observed in the lumen of the AG small intestine.The expression of microsomal triglyceride transfer protein,apolipoprotein B and apolipoprotein C2 was downregulated.Triacylglycerols(TGs),total cholesterol and nonesterified fatty acid(NEFA)levels of the small intestinal tissue were significantly higher in AG mice,but the serum TGs and NEFA levels were reduced in AG mice.CONCLUSION These results indicate that acupuncture at Zu san li,Guan yuan and Yong quan suppressed lipid absorption by downregulating the expression of apolipoproteins in the small intestine. | Jia Han Xin Guo Xiang-Jin Meng Jing Zhang Reimon Yamaguchi Yoshiharu Motoo Sohsuke Yamada | 2020 | World Journal of Gastroenterology2020，26，34： | 4 |
| 7 | Effect of gemcitabine on the expression of apoptosis-related genes in human pancreatic cancer cells显示文摘瞄准:为了调查基因的表示,在人的胰腺的癌症房间在导致 gemcitabine 的细胞毒性包含了。方法:一根人的胰腺的癌症房间线, PANC-1,是有教养的。1x10 (4 ) PANC-1 房间是在 96 井的 plated 微效价盘子。在为 24 h 被孵化以后, gemcitabine 在集中变化 2.5-1000 mg/L 被加到媒介。AlamarBlue 染料方法被用于细胞生长分析。DNA 破碎是用 DNA 破碎的份量上 assayed 连接酶的免疫吸着剂试金(ELISA ) 工具包。奶头和 TP53INP1 mRNA 表示与半量的分析用反向的抄写聚合酶链反应被决定。GSK-3beta 和 phospho-GSK-3beta 蛋白质的表示与西方的污点分析被检验。结果:为在到 gemcitabine 的 48-h 暴露以后的药的 IC50 是 16 mg/L。PANC-1 房间的生长被 gemcitabine 以一种集中依赖者方式(P<0.0001 ) 禁止,房间生长也在整个时间功课(P<0.0001 ) 被禁止。在在 48 h 的对待 gemcitabine 的组的 DNA 破碎率是 44.7% ,而它在未经治疗的组是 25.3% 。奶头 mRNA 表示在与 gemcitabine 被对待以后被减少,而 TP53INP1 mRNA 被 gemcitabine 处理增加。西方的污点分析证明 phospho- GSK-3beta (ser9 ) 被 gemcitabine 处理导致。结论:Gemcitabine 压制 PANC-1 房间增长并且导致 apoptosis。Apoptosis 被认为与抑制被联系奶头和 GSK-3beta,和 TP53INP1 和 pospho-GSK-3beta (ser9 ) 的激活。 | Pei-Hong Jiang Yoshiharu Motoo Norio Sawabu Toshinari Minamoto | 2006 | World Journal of Gastroenterology2006，12，10： | 3 |
| 8 | Traditional Japanese Medicine,Kampo:Its History and Current Status显示文摘Traditional Japanese medicine,Kampo,is used by over 80%of medical doctors in Japan.Owing to its high quality and safety,Kampo has been integrated into modern medicine,and there are 345 randomized controlled trials using Kampo in Japan as of 2010.Although there are a number of articles in top journals about basic science research,we can find only small numbers of high-quality clinical evidence.Since undergraduate education on Kampo has been established,integrative approach with the balanced combination of modern medicine and Kampo is expected to generate good clinical evidence in the near future. | Yoshiharu Motoo Takashi Seki Kiichiro Tsutani | 2011 | Chinese Journal of Integrative Medicine2011，17，3： | 3 |
| 9 | Down-expression of tumor protein p53-induced nuclear protein 1 in human gastric cancer显示文摘瞄准:肿瘤蛋白质的 Overexpression 导致 p53 的原子蛋白质(TP53INP1 ) 1 导致 G1 房间周期拘捕并且增加调停 p53 的 apoptosis。澄清 TP53INP1 的临床的重要性,我们在胃的癌症分析了 TP53INP1 和 p53 表示。方法:TP53INP1 和 p53 表示在胃的癌症的 142 种情况中用免疫组织化学被检验。胃的癌症房间的 apoptosis 用 TUNEL 方法被分析。在 TP53INP1 和 clinicopathological 因素的表示之间的关系统计上被分析。结果:TP53INP1 在 98% 被表示(139/142 盒子) 非癌的胃的纸巾并且在 64% 是下面表示的(91/142 盒子) 从一样的病人的胃的癌症损害。TP53INP1 表示显著地被减少(43.9%) 与井相比或中等在糟糕区分的腺癌区分了腺癌(81.6%) 。入侵粘膜下层的癌症或更深出现了断然降低(59.1%) 与粘膜癌症(85.2%) 相比。TP53INP1 表示的减少或损失显著地与淋巴的侵略被相关(54.3% 对 82.0% 没有淋巴的侵略) 并且节点积极的病人(31.3% 对 68.3% 在节点否定的病人) 。P53 在 68 被表示(47.9%) 胃的癌症的病人,而它在正常胃的纸巾是不在的。一个重要协会也在肿瘤房间在 TP53INP1 地位和 apoptosis 的水平之间被观察:在 TP53INP1 积极的纸巾的 apoptotic 索引在 TP53INP1 否定的部分比那显著地高。最后,当幸存数据被分析时, TP53INP1 表示的损失在预言差的预后(P=0.0006 ) 有重要效果。结论:有胃的癌症的前进的 TP53INP1 积极的率减少。TP53INP1 蛋白质否定性显著地与胃的癌症的好攻击的病理学的显型被联系。TP53INP1 与胃的癌症房间的 apoptosis 有关。TP53INP1 蛋白质的减少的表示可以反映胃的癌症的恶意的等级并且被认为是一个不利预示的因素。 | Pei-Hong Jiang Yoshiharu Motoo Stéphane Garcia Juan Lucio Iovanna Marie-Josèphe Pébusque Norio Sawabu | 2006 | World Journal of Gastroenterology2006，12，5： | 3 |
| 10 | A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences显示文摘 | Motoo Kimura | 1980 | Journal of Molecular Evolution1980，，2： | 3 |
| 11 | Decreased Production of Interleukin-12 and Type 2 Immune Responses Are Marked in Cachectic Patients with Colorectal and Gastric Cancer显示文摘 | Masahiko Shibata Takeshi Nezu Hisao Kanou Hideo Abe Motoo Takekawa Masahiro Fukuzawa | 2002 | Journal of Clinical Gastroenterology2002，，4： | 2 |
| 12 | A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences显示文摘 | Motoo Kimura | 1980 | Journal of Molecular Evolution1980，，2： | 2 |
| 13 | Antitumor effects of saikosaponins,baicalin and baicalein on human hepatoma cell lines显示文摘 | Motoo Y Sawabu N | 1994 | Cancer Lett1994，86，1： | 1 |
| 14 | Expression of clusterin in human pancreatic cancer显示文摘 | Xie M J Motoo Y Su SB | 2002 | Pancreas2002，25，3： | 1 |
| 15 | A simple method for estimating evolutionary rates of base substitutions through comparative studies of nucleotide sequences显示文摘 | Motoo Kimura | 1980 | Journal of Molecular Evolution1980，，2： | 1 |
| 16 | Antitumor effects of saikosaponins, baicalinand baicalein on human hepatoma cell lines显示文摘 | Motoo Y Sawabu N | 1994 | CancerLett1994，86，1： | 1 |
| 17 | Expression of transforming growth factor-beta in spontaneous chronic pancreatitis in the WBN/Kob rat显示文摘 | Su SB Motoo Y Xie MJ | 2000 | Dig Dis Sci2000，45，1： | 1 |
| 18 | Serum levels of pancreatitis-associated protein in digestive diseases with special reference to gastrointestinal cancers显示文摘 | Motoo Y Satomura Y Mouri I | 1999 | D/g Dis Sci1999，44，： | 1 |
| 19 | Effect of die approach geometry and bearing length on residual stress after bar drawing显示文摘 | Asakawa Motoo Sasaki Wataru Shishido Shunsuke | 2002 | Wire Journal International2002，35，10： | 1 |
| 20 | Antitumor effects of saikosaponins, baicalin and baicalein on human hepatoma cell lines显示文摘 | Motoo Y Sawabu N | 1994 | Cancer Letters1994，86，1： | 1 |
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