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| 1 | Endoscopic papillary large balloon dilation after limited sphincterotomy for difficult biliary stones显示文摘AIM:To assess the efficacy and safety of endoscopic papillary large balloon dilation after biliary sphincterotomy for difficult bile duct stones retrieval.METHODS:Retrospective review of consecutive patients submitted to the technique during 18 mo.The main outcomes considered were:efficacy of the procedure(complete stone clearance;number of sessions;need of lithotripsy) and complications.RESULTS:A total of 30 patients with a mean age of 68 ± 10 years,23 female(77%) and 7 male(23%) were enrolled.In 10 patients,a single stone was found in the common bile duct(33%) and in 20 patients multiple stones(67%) were found.The median diameter of the stones was 17 mm(12-30 mm).Dilations were performed with progressive diameter Through-TheScope balloons(up to 12,15) or 18 mm.Complete retrieval of stones was achieved in a single session in 25 patients(84%) and in two sessions in 4 patients(13%).Failure occurred in 1 case(6%).Mechanical lithotripsywas performed in 6 cases(20%).No severe complications occurred.One patient(3%) had mild-grade post-endoscopic retrograde cholangiopancreatography(ERCP) pancreatitis.CONCLUSION:Endoscopic balloon dilatation with a large balloon after endoscopic sphincterotomy is a safe and effective technique that could be considered an alternative choice in therapeutic ERCP. | Ana Rebelo Pedro Moutinho Ribeiro António Pinto Correia José Cotter | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，5： | 22 |
| 2 | 在为困难的 choledocholithiasis 的 sphincterotomy 以后的内视镜的乳突的汽球膨胀: 控制盒子的研究显示文摘 AIM:To evaluate the efficacy and safety of endoscopic sphincterotomy(EST) + endoscopic papillary large balloon dilation(EPLBD)vs isolated EST.METHODS:We conducted a retrospective single center study over two years,from February 2010 to January 2012.Patients with large(≥ 10 mm),single or multiple bile duct stones(BDS),submitted to endoscopic retrograde cholangio-pancreatography(ERCP) were included.Patients in Group A underwent papillary large balloon dilation after limited sphincterotomy(EST+EPLBD),using a through-the-scope balloon catheter gradually inflated to 12-18 mm according to the size of the largest stone and the maximal diameter of the distal bile duct on the cholangiogram.Patients in Group B(control group) underwent isolated sphincterotomy.Stones were removed using a retrieval balloon catheter and/or a dormia basket.When necessary,mechanical lithotripsy was performed.Complete clearance of the bile duct was documented with a balloon catheter cholangiogram at the end of the procedure.In case of residual lithiasis,a double pigtail plastic stent was placed and a second ERCP was planned within 4-6 wk.Some patients were sent for extracorporeal lithotripsy prior to subsequent ERCP.Outcomes of EST+EPLBD(Group A) vs isolated EST(Group B) were compared regarding efficacy(complete stone clearance,number of therapeutic sessions,mechanical and/or extracorporeal lithotripsy,biliary stent placement) and safety(frequency,type and grade of complications).Statistical analysis was performed using χ 2 or Fisher’s exact tests for the analysis of categorical parameters and Student’s t test for continuous variables.A P-value of less than 0.05 was considered statistically significant.RESULTS:One hundred and eleven patients were included,68(61.3%) in Group A and 43(38.7%) in Group B.The mean diameter of the stones was similar in the two groups(16.8 ± 4.4 and 16.0 ± 6.7 in Groups A and B,respectively).Forty-eight(70.6%) patients in Group A and 21(48.8%) in Group B had multiple BDS(P = 0.005).Overall,balloon dilation was performed up to 12 mm in 10(14.7%) patients,13.5 mm in 17(25.0%),15 mm in 33(48.6%),16.5 mm in 2(2.9%) and 18 mm in 6(8.8%) patients,taking into account the diameter of the largest stone and that of the bile duct.Complete stone clearance was achieved in sixty-five(95.6%) patients in Group A vs 30(69.8%) patients in Group B,and was attained within the first therapeutic session in 82.4% of patients in Group A vs 44.2% in Group B(P < 0.001).Patients submitted to EST+EPLBD underwent fewer therapeutic sessions(1.1 ± 0.3 vs 1.8 ± 1.1,P < 0.001),and fewer required mechanical(14.7% vs 37.2%,P = 0.007) or extracorporeal(0 vs 18.6%,P < 0.001) lithotripsy,as well as biliary stenting(17.6% vs 60.5%,P < 0.001).The rate of complications was not significantly different between the two groups.CONCLUSION:EST+EPLBD is a safe and effective technique for treatment of difficult BDS,leading to high rates of complete stone clearance and reducing the need for lithotripsy and biliary stenting. | Bruno Rosa Pedro Moutinho Ribeiro Ana Rebelo António Pinto Correia José Cotter | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，5： | 21 |
| 3 | Concordance of non-invasive mechanical and serum tests for liver fibrosis evaluation in chronic hepatitis C显示文摘AIM To determine the sensitivity and specificity of liver stiffness measurement(LSM) and serum markers(SM) for liver fibrosis evaluation in chronic hepatitis C.METHODS Between 2012 and 2014,81 consecutive hepatitis C virus(HCV) patients had METAVIR score from liver biopsy compared with concurrent results from LSM [transient elastography(TE) [FibroS can~/ARFI technology(Virtual Touch~)] and SM [FIB-4/aspartate aminotransferase-toplatelet ratio index(APRI)].The diagnostic performance of these tests was assessed using receiver operating characteristic curves.The optimal cut-off levels of each test were chosen to define fibrosis stages F ≥ 2,F ≥ 3 and F = 4.The Kappa index set the concordance analysis.RESULTS Fifty point six percent were female and the median age was 51 years(30-78).Fifty-six patients(70%) weretreatment-na?ve.The optimal cut-off values for predicting F ≥ 2 stage fibrosis assessed by TE were 6.6 kP a,for acoustic radiation force impulse(ARFI) 1.22 m/s,for APRI 0.75 and for FIB-4 1.47.For F ≥ 3 TE was 8.9 kP a,ARFI was 1.48 m/s,APRI was 0.75,and FIB-4 was 2.For F = 4,TE was 12.2 kP a,ARFI was 1.77 m/s,APRI was 1.46,and FIB-4 was 3.91.The APRI could not distinguish between F2 and F3,P = 0.92.The negative predictive value for F = 4 for TE and ARFI was 100%.Kappa index values for F ≥ 3 METAVIR score for TE,ARFI and FIB-4 were 0.687,0.606 and 0.654,respectively.This demonstrates strong concordance between all three screening methods,and moderate to strong concordance between them and APRI(Kappa index = 0.507).CONCLUSION Given the costs and accessibility of LSM methods,and the similarity with the outcomes of SM,we suggest that FIB-4 as well as TE and ARFI may be useful indicators of the degree of liver fibrosis.This is of particular importance to developing countries. | Denise C Paranaguá-Vezozzo Adriana Andrade Daniel F C Mazo Vinicius Nunes Ana L Guedes Taisa G Ragazzo Renata Moutinho Lucas S Nacif Suzane K Ono Venancio A F Alves Flair J Carrilho | 2017 | World Journal of Hepatology2017，9，8： | 7 |
| 4 | Cadmium toxicity affects photosynthesis and plant growth at different levels 显示文摘 | Dias blC Monteiro C Moutinho - Pereira J | 2013 | Aeta Physiologiae Plantarum2013，35，4： | 1 |
| 5 | Market Orientation and Performance: Modelling a Neural Network 显示文摘 | Silva M Moutinho L Coelho A Marques A | 2009 | European Journal of Marketing2009，43，3： | 1 |
| 6 | Relocation of a Ca2 + -dependent protein kinase activity during pollen tube reorientation显示文摘 | Moutinho A Trewavas A J Malho R | 1998 | Plant Cell1998，10，： | 1 |
| 7 | Consumer behavior in tourism显示文摘 | Moutinho L | 1997 | European Jour- nal of Marketing1997，21，0： | 1 |
| 8 | Ethnopharmacological notes about ancient uses of medicinal plants in Trás-os-Montes (northern of Portugal)显示文摘 | José Manuel Neves Carla Matos Carla Moutinho Glória Queiroz Lígia Rebelo Gomes | 2009 | Journal of Ethnopharmacology2009，，2： | 1 |
| 9 | Consumer behavior in tourism显示文摘 | Moutinho L | 1987 | European Journal of Marketing1987，21，10： | 1 |
| 10 | Tropical Deforestation and the Kyoto Protocol 显示文摘 | Santilli M Moutinho P Sehwartzman S | 2005 | Climatic Change2005，71，3： | 1 |
| 11 | Hover control of an UAV with backstepping design including input saturations显示文摘 | Azinheira J R Moutinho A | 2008 | IEEE Trans on Control System Technologe2008，16，3： | 1 |
| 12 | Attitude estimation in SO(3):A comparative UAV case study显示文摘 | Moutinho A Figueir?a M Azinheira J R | 2015 | Journal of Intelligent&Robotic Systems2015，80，3： | 1 |
| 13 | A backstepping controller for path-tracking of an underactuated autonomous airship显示文摘 | Azinheira J R Moutinho A Paiva E C | 2009 | Int J Robust and Nonlinear Control2009，19，4： | 1 |
| 14 | Abnormal uterine bleeding as a presenting symptom is related to multiple uterine leiomyoma : an ultrasound - based study 显示文摘 | FONSECA MOUTINHO J A BARBOSA L S TORRES D G | 2013 | Int J Womens Health2013，18，5： | 1 |
| 15 | Brand relationships through brand reputation and brand tribalism显示文摘 | Veloutsou C Moutinho L | 2009 | Journal of Business Research2009，62，3： | 1 |
| 16 | Dynamic epigenetic reg- ulation of the micmRNA-200 family mediates epithelial and mes- enchymal transitions in human tumorigenesis 显示文摘 | Davalos V Moutinho C Villanueva A | 2012 | Oncogene2012，31，16： | 1 |
| 17 | Brand relationships through brand reputation and brand tribalism显示文摘 | Cleopatra Veloutsou Luiz Moutinho | 2008 | Journal of Business Research2008，，： | 1 |
| 18 | Direct evi- dence of a buried homojunetion in Cu (In,Ga)Se2 solar cells 显示文摘 | JIANG C S HASOON F S MOUTINHO H R | 2003 | Appl Phys Lett2003，82，： | 1 |
| 19 | The role of brand image,product involvement,and knowledge in explaining consumer purchase behaviour of counterfeits:Direct and indirect effects显示文摘 | Bian X Moutinho L | 2011 | European Journal of Marketing2011，45，12： | 1 |
| 20 | Consumer behavior in tourism显示文摘 | Moutinho L | 1987 | European Journal of Marketing1987，21，10： | 1 |
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