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| 1 | Regulated upon activation,normal T cell expressed and secreted(RANTES)levels in the peripheral blood of patients with Alzheimer’s disease显示文摘Alzheimer’s disease(AD)is the most common type of dementia,but it is very difficult to diagnose with certainty,so many AD studies have attempted to find early and relevant diagnostic markers.Regulated upon activation,normal T cell expressed and secreted(RANTES,also known as C-C chemokine ligand)is a chemokine involved in the migration of T cells and other lymphoid cells.Changes in RANTES levels and its expression in blood or in cerebrospinal fluid have been reported in some neurodegenerative diseases,such as Parkinson’s disease and multiple sclerosis,but also in metabolic diseases in which inflammation plays a role.The aim of this observational study was to assess RANTES levels in peripheral blood as clinical indicators of AD.Plasma levels of RANTES were investigated in 85 AD patients in a relatively early phase of AD(median 8.5 months after diagnosis;39 men and 46 women;average age 75.7 years),and in 78 control subjects(24 men and 54 women;average age 66 years).We found much higher plasma levels of RANTES in AD patients compared to controls.A negative correlation of RANTES levels with age,disease duration,Fazekas scale score,and the medial temporal lobe atrophy(MTA)score(Scheltens’s scale)was found in AD patients,i.e.,the higher levels corresponded to earlier stages of the disease.Plasma RANTES levels were not correlated with cognitive scores.In AD patients,RANTES levels were positively correlated with the levels of pro-inflammatory cytokines interleukin-6 and tumor necrosis factor-α,which is consistent with the wellknown fact that AD is associated with inflammatory processes.RANTES levels were also positively correlated with insulin levels in AD patients,with insulin resistance(HOMA-R)and pancreatic beta cell function(HOMA-F).This study evaluated several clinical and metabolic factors that may affect plasma levels of RANTES,but these factors could not explain the increases in RANTES levels observed in AD patients.Plasma levels of RANTES appear to be an interesting peripheral marker for early stages of AD.The study was approved by the Ethics Committee of Institute of Endocrinology,Prague,Czech Republic on July 22,2011. | Gabriela Vacínová Daniela Vejražkova Robert Rusina Iva Holmerová Hana Vaňková Eva Jarolímová Josef Včelák Běla Bendlová Markéta Vaňková | 2021 | Neural Regeneration Research2021，16，4： | 3 |
| 2 | Using new physics and technology to advance electrostimulated rolling of metals and alloys显示文摘Electrostimulated deformation of metals and alloys, using groove or smooth rolling, requires that several important conditions are satisfied. (1) The deformation site must geometrically overlap with the flow of electric current passing through a strip between the rolls; (2) The density of direct or alternating electric current supplied to deformation site must be sufficiently high (of an order of 104-106А/cm^2); (3) An efficient heat removal from the deformation site must be achieved. In general, the temperature of a strip must be within the range of 100-300℃. (4) The electric resistance at the roll-strip interface must be minimized. Our recent studies also indicate that the electrostimulated rolling in the shortcut regime is a further condition for obtaining high quality rolling of metals. In this regime, the rolls are placed in physical contact even in the absence of a strip that ensures an uninterrupted passage of electric current between the rolls. | Konstantin M. Kli mov Ivan I . Novikov | 2005 | 广东有色金属学报2005，15，2： | 2 |
| 3 | An S-band virctor with premodulated electron beam based on a compact generator with inductive energy storage显示文摘 | Efre mov A M Zherlitsyn A A Kitsanov S A | 2001 | Tech Phys Lett2001，27，4： | 1 |
| 4 | Identification of dis- crete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T cell-suppressive activity显示文摘 | Mov~edi K Guilliams M Van den Bossche J | 2008 | Blood2008，111，8： | 1 |
| 5 | Persistence of antibodies in a population immunized with oral polio vaccine (OPV)显示文摘 | Srámová H Teply V Svandová E | 1979 | J Hyg Epidemiol Microbiol Immtmol1979，23，2： | 1 |
| 6 | Genetic structure of experimental populations and reproductive fitness in a heterocarpic plant Atriplex tatarica (Chenopodiaceae)显示文摘 | Mandák B B(i)mov(a) K Placková I | | 0，，11： | 1 |
| 7 | Pontaneous Cryptosporidium infection in weaned rabbits显示文摘 | Pavlásek I Lávicka M T (u) mová E | 1996 | Vet Med(Praha)1996，41，12： | 1 |
| 8 | Interaction of hen production type,age,and temperature on laying pattern and egg quality显示文摘 | T(u) mová E Gous R | | 0，，05： | 1 |
| 9 | Metalized zeolites as a catalyst for hydrosilylation显示文摘 | Kopylva L I Kharla mov V V Pumknarevich V B | 1994 | Zhobshch Khim1994，64，10： | 1 |
| 10 | The effect of oviposition time and genotype on egg quality characteristics in egg type hens显示文摘 | T(u)mová E Zita L Huben(y) M et ol | | 0，，： | 1 |
| 11 | Testicular fixation following torsion of the spermatic cord-does it guarantee prevention of recurrent torsion event? 显示文摘 | MOV Y PINTHUS JH NADN A | 2006 | J Urol2006，175，1： | 1 |
| 12 | The effect of weaning age on performance and nutrient digestibility of broiler rabbits显示文摘 | Zita L T(u)mová E Skrivanová V | | 0，，： | 1 |
| 13 | Influence of positional accuracy,sample size and scale on modelling species distributions:a review显示文摘 | MoudrV ímováP | 2012 | International Journal of Geographical Information Science2012，26，11： | 1 |
| 14 | Ulnar coronoid process anatomy possible implications for elbow instability 显示文摘 | Above RH Mov OJ Howard C | 2006 | Clin Orthop2006，449，： | 1 |
| 15 | Accumulative roll-bonding:first experience with a twin-roll cast AA8006 alloy显示文摘 | Karlík M Homolaa P Slámová M | 2004 | Journal of Alloys and Compounds2004，378，12： | 1 |
| 16 | Heterogeneity of stomatal density in the second wheat leaf显示文摘 | A. Bímová | 1992 | Biologia Plantarum1992，，5： | 1 |
| 17 | Impact of the growth hormone replacement on bone status in growth hormone deficient adults显示文摘 | Ku~ma M Ku~mov~t Z Zelinkov6 Z | 2014 | Growth Horm IGF Res2014，24，1： | 1 |
| 18 | Wnt-expressing rat embryonic fibroblasts suppress Apo2L/TRAIL-induced apoptosis of human leukemia cel s显示文摘 | Doubravská L Símová S Cermak L | | 0，，04： | 1 |
| 19 | Enzymatic preparation of silybin phase II metabolites: sulfation using aryl sulfotransferase from rat liver显示文摘 | Kate?ina Purchartová Leonie Engels Petr Marhol Miroslav ?ulc Marek Kuzma Kristyna Slámová Lothar Elling Vladimír K?en | 2013 | Applied Microbiology and Biotechnology2013，，24： | 1 |
| 20 | High-sensitivity CRP is an independent risk factor for all fractures and vertebral fractures in elderly men:the Mr OS Sweden study显示文摘 | Eriksson AL Movérare-Skrtic S Ljunggren | 2014 | J Bone Miner Res2014，29，2： | 1 |
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