| 1 | Update on hepatitis B and C virus diagnosis显示文摘Viral hepatitis B and C virus(HBV and HCV) are responsible for the most of chronic liver disease worldwide and are transmitted by parenteral route, sexual and vertical transmission. One important measure to reduce the burden of these infections is the diagnosis of acute and chronic cases of HBV and HCV. In order to provide an effective diagnosis and monitoring of antiviral treatment, it is important to choose sensitive, rapid, inexpensive, and robust analytical methods. Primary diagnosis of HBV and HCV infection is made by using serological tests for detecting antigens and antibodies against these viruses. In order to confirm primary diagnosis, to quantify viral load, to determine genotypes and resistance mutants for antiviral treatment, qualitative and quantitative molecular tests are used. In this manuscript, we review the current serological and molecular methods for the diagnosis of hepatitis B and C. | Livia Melo Villar Helena Medina Cruz Jakeline Ribeiro Barbosa Cristianne Sousa Bezerra Moyra Machado Portilho Letícia de Paula Scalioni | 2015 | World Journal of Virology2015，4，4： | 9 |
| 12 | Predictors of future stroke in adults 60-64 years living in the community显示文摘AIM:To investigate predictors of incident stroke in a large epidemiological sample of cognitively healthy individuals in their early 60's.METHODS:Cardiovascular(systolic and diastolic blood pressure, hypertension status and medication, body mass index, lung forced vital capacity), lifestyle(alcohol intake, smoking, physical activity), mental health(anxiety and depression status, medication and symptomatology), cognition(executive function, processing speed, working memory, sensorimotor skills), and personality measures(behavioural inhibition and activation, positive and negative affect, neuroticism, psychoticism, extraversion) were investigated as predictors of incident stroke in 1774 participants from the Personality and Total Health Through Life Project over an 8-year follow-up.Logistic regression analyses controlled for age, gender, and education were conducted in the whole cohort as well as in case-control subanalyses including precisely matched controls to identify factors associated with stroke incidence.RESULTS:The cohort selected had a mean age of 62.5 years(SD = 1.5) and was 48.6% female with an average of 14.1 years of education(SD = 2.6).When 28 individuals with incident stroke were compared to 1746 cognitively healthy individuals in multivariate logistic regression analyses the only significant predictors of stroke across the five domains considered(cardiovascular, lifestyle, mental health, cognition, personality) and after controlling for gender, age, and education were systolic blood pressure(per unit above 140 mm Hg:OR = 1.04, 95%CI:1.01-1.07, P = 0.002), smoking(trend OR = 2.28, 95%CI:0.99-5.24, P = 0.052), and sensorimotor skills(purdue pegboard:OR = 0.80, 95%CI:0.62-0.96, P = 0.037).Similarly, in matched-control analyses significant group differences were found for systolic blood pressure(P = 0.001), smoking(P = 0.036), and sensorimotor skills(P = 0.028).CONCLUSION:Identified predictors of incident stroke in community-living individuals included high systolic blood pressure and smoking- but also, sensorimotor performance, a measure which has not yet been reported in the literature. | Nicolas Cherbuin Leeanne Carey Moyra Mortby Kaarin J Anstey | 2016 | World Journal of Neurology2016，6，1： | 0 |
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