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| 1 | Transient micro-elastography:A novel non-invasive approach to measure liver stiffness in mice显示文摘AIM:To develop and validate a transient micro-elastography device to measure liver stiffness(LS) in mice.METHODS:A novel transient micro-elastography(TME) device,dedicated to LS measurements in mice with a range of measurement from 1-170 kPa,was developed using an optimized vibration frequency of 300 Hz and a 2 mm piston.The novel probe was validated in a classical fibrosis model(CCl4) and in a transgenic murine model of systemic amyloidosis.RESULTS:TME could be successfully performed in control mice below the xiphoid cartilage,with a mean LS of 4.4 ± 1.3 kPa,a mean success rate of 88%,and an excellent intra-observer agreement(0.98).Treatment with CCl4 over seven weeks drastically increased LS as compared to controls(18.2 ± 3.7 kPa vs 3.6 ± 1.2 kPa).Moreover,fibrosis stage was highly correlated with LS(Spearman coefficient = 0.88,P < 0.01).In the amyloidosis model,much higher LS values were obtained,reaching maximum values of > 150 kPa.LS significantly correlated with the amyloidosis index(0.93,P < 0.0001) and the plasma concentration of mutant hapoA-□(0.62,P < 0.005).CONCLUSION:Here,we have established the first non-invasive approach to measure LS in mice,and have successfully validated it in two murine models of high LS. | Cécile Bastard Matteo R Bosisio Michèle Chabert Athina D Kalopissis Meriem Mahrouf-Yorgov Hélène Gilgenkrantz Sebastian Mueller Laurent Sandrin | 2011 | World Journal of Gastroenterology2011，17，8： | 4 |
| 2 | Computed tomographic scanning without oral contrast solution for blunt bowel and mesenteric injuries in abdominal trauma显示文摘 | Allen T L Mueller M T Bonk R T | 2004 | J Trauma2004，56，2： | 1 |
| 3 | Effect of SiO2 on densification and microstructure development in Nd:YAG transparent ceramics 显示文摘 | STEVENSON A J LI Xin MART1NEZ M A ANDERSON J M SUCHY D L KUPP E R DICKEY1 Z C MUELLER K T MESSING G L | 2011 | J Am Ceram Soc2011，94，： | 1 |
| 4 | Addition of chloride to a prepartal diet high in cations increase 1,25-dihydroxyvitamin D response to hypotalcemia preventing milk fever显示文摘 | Horst R L F J Mueller J K Miller | 1991 | Dairy science1991，，70： | 1 |
| 5 | A Novel Approach to Determine the Glyphosate Tolerant Trait in Soybeans显示文摘 | MIAN C L PANTALONE V R MUELLER T C | 2004 | J Agric Food Chem2004，52，： | 1 |
| 6 | Addition of chloride to a prepartal diet high in cations increases 1,25-dihydmxyvitamin D response to hypocalcemia preventing milk fever显示文摘 | GOFF J P HORST R L MUELLER F J | 1991 | Dairy Sci1991，74，： | 1 |
| 7 | Progress and current status of percutaneous aortic valve replacement:results of three device generations of the CoreValve Revalving system显示文摘 | Grube E Buellesfeld L Mueller R | | 0，，： | 1 |
| 8 | The draft genome of watermelon (Citrullus lanatus ) and reseqnencing of 20 diverse accessions显示文摘 | Guo S G Zhang J G Sun H H Salse J Lucas W J Zhang H Y Zheng Y Mao L Y Ren Y WangZ W Min J M Guo X S Murat F Ham B K Zhang Z L Gao S Huang M Xu Y M Zhong S L Bombarely A Mueller L Zhao H He H Q Zhang Y Zhang Z H Huang S W Tan T Pang E Lin K Hu Q Kuang H H Ni P X Wang B Liu J G Kou Q H Hou W J Zou X H Jiang J Gong G Y Klee K Schoof H Huang Y Hu X S Dong S S Liang D Q Wang J Wu K Xia Y Zhao X Zheng Z Q Xing M Liang X M Huang B Q Lv T Wang J Y Yin Y Yi H P Li R Q Wu M Z Levi A Zhang X P Giovannoni J Wang J Li YF Fei Z J Xu Y | 2013 | Nature genetics2013，45，1： | 1 |
| 9 | NPR1 modulates crosstalk between salicylate-and jasmonate-dependent defence pathways through a novel function in the cytosol显示文摘 | SPOEL S H KOORNNEEF A CLAESSENS SMC KORZELUS J P VAN PELT J A MUELLER M J BUCHALA A J METRAUX J P BROWN R KAZZAN K VAN LOON L C DONG X N PIETERSE C M J | 2003 | Plant Cell2003，15，： | 1 |
| 10 | Macrokinetic analysis of blockade of NMDA-gated currents by substituted alcohols, alkanes and ethers显示文摘 | Hugh E Criswell Zhen Ming Nathanial Pleasant Benjamin L Griffith Robert A Mueller George R Breese | 2004 | Brain Research2004，，1： | 1 |
| 11 | Nurse staffing and quality of patient care显示文摘 | Kane R L Shamliyan T Mueller C | 2007 | Evid Rep Technol Assess (Full Rep)2007，，151： | 1 |
| 12 | A snapshot of the emerging tomato genome sequence显示文摘 | Mueller L A Lankhorst R K Tanksley S D | 2009 | Plant Genome2009，2，： | 1 |
| 13 | Experimental validation of a commercial 3D dose verification system for intensity - modulated arc therapies显示文摘 | Boggula R Lorenz F Mueller L | 2010 | Phys Med Biol2010，55，19： | 1 |
| 14 | Ultrasound-guided spinal fracture repositioning,ligamentotaxis,and remodeling after thoracolumbar burst fractures显示文摘 | Mueller L A Degreif J Schmidt R | | 0，，20： | 1 |
| 15 | Effects of pore size and void fraction on cellular adhesion, proliferation, and matrix deposition 显示文摘 | ZELTINGER J SHEERWOOD J K GRAHAM D M MUELLER R GRIFFITH L G | 2001 | Tissue Eng2001，7，5： | 1 |
| 16 | Biogeography and systematics of Bangia (Bangiales,Rhodophyta) based on the rubisco spacer,rbcL gene and 18S rRNA gene sequences and morphological analyses in North America显示文摘 | Mueller K M Sheath R G Vis M L | 1998 | Phycologia1998，37，3： | 1 |
| 17 | An assessment of density functional methods for studying molecular adsorption in cluster models of zeolites显示文摘 | Zygmunt S A Mueller R M Curtiss L A | 1998 | J Mol Struc-Theochem1998，430，： | 1 |
| 18 | Low-dose adenoviral immunotherapy of rat hepatocellular carcinoma usiong singlechain interleukin-12显示文摘 | Waehler R htrich H Mueller L | 2005 | Hum Gene Ther2005，16，3： | 1 |
| 19 | Progress and current status of percutaneous aortic valve replacement: results of three device genera- tions of the CoreValve Revalving system 显示文摘 | Grube E Buellesfeld L Mueller R | 2008 | Circ Cardiovasc Interv2008，1，3： | 1 |
| 20 | The phenomenon and efficiency of ligamentotaxis after dorsal stabilization of thoracolum- bar burst fractures 显示文摘 | Mueller L A Mueller L P Schmidt R | 2006 | Arch Orthop Trauma Surg2006，126，6： | 1 |
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