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| 1 | Association of farnesyl diphosphate synthase polymorphisms and response to alendronate treatment in Chinese postmenopausal women with osteoporosis显示文摘 | Liu Y Li M Zhou PR Xing XP Xia WB Xu L Liu H J Zhang ZL LiaoEY Chen DC Liu J Tao TZ Wu W | 2014 | Chinese Medical Journal2014，，4： | 16 |
| 2 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 3 | Sol-gel derived HA/TiO_2 double coatings on Ti scaffolds for orthopaedic applications显示文摘Hydroxyapatite/titania (HA/TiO2) double layers were coated onto Ti scaffolds throughout for orthopaedic applications by sol-gel method. Differential scanning calorimetry (DSC), thermogravimetric analysis (TG) and X-ray diffractometry (XRD) were used for the characterisation of the phase transformations of the dried gels and coated surface structures. Scanning electron microscope (SEM) equipped with energy dispersive spectrometry (EDS) was used for the observation and evaluation of the morphology and phases of the surface layers and for the assessment of the in vitro tests. The in vitro assessments were performed by soaking the HA/TiO2 double coated samples into the simulated body fluid (SBF) for various periods. The TiO2 dipping-coating method at a speed of 12 cm/min, followed by a heat treatment at 600 ℃ for 20 min. The HA la lyaeyre wr wasa ssu cbosaetqeude bnytl ya dipping-coated on the outer surface at the same speed and then heat-treated at difference temperatures. The results indicat that the HA phase begins to crystallize after a heat treatment at 560 ℃. The crystallinity increases obviously at 760 ℃. SEM observations find no delamination or crack at the interfaces of HA/TiO2 and TiO2/Ti. The HA/TiO2 coated Ti scaffolds displays excellent bone-like apatite forming ability when it is soaked into SBF. Ti scaffolds after HA/TiO2 double coatings can be anticipated as promising implant materials for orthopaedic | XU W HU W Y LI M H MA Q Q P. D. HODGSON WEN C E | 2006 | 中国有色金属学会会刊:英文版2006，16，B01： | 5 |
| 4 | 油炸食品与心血管病风险和全因死亡率的关系:观察性研究的荟萃分析显示文摘研究者进行了一项荟萃分析,包括剂量反应分析,以定量确定油炸食品摄入与普通成年人群心血管病风险和全因死亡率之间的关系。方法:研究者在PubMed、EMBASE和Web of Science上检索2020年4月11日之前的所有文章。应用随机效应模型估计总的相对危险度(relative risks,RR)和95%CI。结果:与最低油炸食品摄入量相比,最高摄入量者主要心血管事件的总RR(95%CI)=1.28(1.15~1.43),n=17,I^(2)=82.0%,其中前瞻性研究:1.24(1.12~1.38),n=13,I^(2)=75.7%. | 刘青(译) 练桂丽(审校) Qin P Zhang M Han M Liu D Luo X Xu L Zeng Y Chen Q Wang T Chen X Zhou Q Li Q Qie R Wu X Li Y Zhang Y Wu Y Hu D Hu F | 2021 | 中华高血压杂志2021，29，2： | 3 |
| 5 | 青少年甘油磷酸胆碱代谢和心血管病的危险因素:一项队列研究显示文摘甘油磷酸胆碱(glycerophosphocholine,GPC)代谢物可调节动脉粥样硬化,从而导致心血管病风险。临床前期心血管病可能从青春期就开始。研究人员应用靶向血清脂质组学鉴定一组新的GPC,并测试在青春期时这些GPC中的任何一种是否与心血管病传统危险因子,如过量内脏脂肪、升高的血压、胰岛素抵抗和致动脉粥样硬化血脂异常相关。 | Syme C Czajkowski S Shin J Abrahamowicz M Leonard G Perron M Richer L Veillette S Gaudet D Strug L Wang Y Xu H Taylor G Paus T Bennett S Pausova Z 刘莉 叶鹏 | 2016 | 中华高血压杂志2016，24，10： | 3 |
| 6 | 全颗粒饲料对奶牛生产性能的影响显示文摘饲料中的中性洗涤纤维(NDF)含量和饲料颗粒直径是影响瘤胃功能的重要因素。试验评估了以颗粒饲料为主的奶牛瘤胃健康情况、NDF消化率和生产性能。选取8头荷斯坦母牛(336±30 d,体重346±35 kg),随机分配到交叉重复试验组中,奶牛安置于牛栏,自由采食。试验期为3周,前两周是适应期,最后一周为数据收集期。各组饲粮原料相同,但物理形式不同,分为全混合日粮(TMR)和颗粒料(直径=8 mm)。两组间物理有效NDF(pe NDF)不同,TMR组为39.8%,颗粒料组为11.8%。在试验过程中,干物质采食量(DMI)、饮水量、瘤胃反刍时间、瘤胃温度和pH情况均记录。3周后收集粪样,确定潜在的可消化NDF总消化率(pdNDF)。每阶段结束后计算平均日增重和饲料转化率。颗粒料组的DMI、DMI/体重和饮水量更高。而两组间平均日增重和饲料转化率无显著差异。颗粒料组的瘤胃反刍时间为241 min·d-1低于TMR组的507 min·d-1。饲料的不同物理外形对瘤胃温度、瘤胃pH无显著影响。TMR组的pdNDF总消化率为90.25%高于颗粒料组的86.82%。试验结果表明,动物易接受完整的颗粒饲料,DMI较高,且反刍时间减少,但瘤胃pH无显著变化。TMR组的pdNDF消化率显著增加。尽管两组奶牛在DMI和纤维消化方面表现不同,但总体表现相似,两组饲料的保存时间与其物理形式有关。在短期内,提供能满足NDF需求的完全颗粒饲料可改善瘤胃健康状况和动物生产性能,而较长时间的数据则需要进一步试验。 | Wang J Yang M Cao M Lin Y Che L Q Duraipandiyan V Al-Dhabi N A Fang Z F Xu S Y Feng B Liu G Wu D Bonfante E Palmonari A Mammi L Canestrari G Fustini M Formigoni A | 2016 | 饲料博览2016，0，12： | 2 |
| 7 | Characterization of the promoter region of the human somatostatin receptor subtype 2 gene and localization of sequences required for estrogen-responsiveness显示文摘 | Xu Y Berelowitz M Bruno JF | 1998 | Mol Cell Endocrinol1998，139，： | 2 |
| 8 | Seismic response control of frame structures using magnetorheological/electrorheological dampers显示文摘 | Xu Y L Qu W L Ko J M | 2000 | Earthquake Engineering and Structural Dynamics2000，29，： | 2 |
| 9 | 缺血性脑卒中后的中期血压变异性与临床结局的关系显示文摘本研究旨在探讨急性脑卒中患者发病7d内的中期血压变异性(blood pressure variability,BPV)与预后的关系。方法:本研究纳入873例急性缺血性脑卒中患者。通过计算发病7d内的收缩压和舒张压的变异系数来评价中期BPV。 | Wang Y Wang J Meng P Liu N Ji N Zhang G Xu B Zhou X Sun Y Xu Y Hui R He M 陈云 叶鹏 | 2018 | 中华高血压杂志2018，26，5： | 2 |
| 10 | 纳米光子结构软膜紫外光固化纳米压印(英文)显示文摘紫外光固化纳米压印是实现纳米结构批量复制的一种新技术.其特点是低成本和高分辨,而且可以达到极高的套刻精度.为了得到大面积图案的均匀复制,可用聚二甲基硅氧烷(PDMS)制备透光的压印软模板.其母版图案可由高分辨率电子束曝光和反应离子刻蚀的方法在硅片基底上获得,然后用浇注的方法将图案转移到PDMS上.本实验特别发展了紫外光固化纳米压印适用于软膜压印的双层膜图型转移技术.该双层膜由廉价的光胶和聚甲基丙烯酸甲脂(PMMA)构成.对光胶层的压印可用普通的光学曝光仪实现.然后再将图案用反应离子刻蚀的方法转移到PMMA层中.为了证明方案的可行性,在两种不同材料的半导体基片上压印了三角晶格的光子晶体和准晶结构的图案,并用剥离的方法将它们转移到金属薄膜上,最后成功地进行了硅片刻蚀实验.相信这一纳米制做方法对大面积纳米光子结构和光学集成芯片的制造是普遍适用的. | SHI J WANG Z M BAO K PEROZ C BELOTTI M XU L P LUO C X SUN M H ZHANG B JI H OUYANG Q CHEN Y | 2006 | 纳米技术与精密工程2006，4，3： | 2 |
| 11 | Tetal,optical in-fiber grating high pressure senser 显示文摘 | XU M G REEKIEL CHOW Y | 1993 | Electron Letters1993，29，4： | 2 |
| 12 | C3d enhancement of antibodies to Hemagglutinin accelerates protection against influenza virus challenge显示文摘 | Ross T M Xu Y Bright R A | 2000 | Nat Immunol2000，1，2： | 2 |
| 13 | Characterization of aroma compounds in apple cider using solvent-assisted flavor evaporation and headspace solid-phase microextraction显示文摘 | XU Y FAN W L QIAN M C | 2007 | J Agric Food Chem2007，55，8： | 1 |
| 14 | Multilayer relaxation of fcc metals (001) surface: A modified embedded atom method study显示文摘 | Zhang J M Shu Y Xu K W | 2006 | Solid State Communications2006，137，： | 1 |
| 15 | Ozone-induced grafting phosphorylcholine polymer onto silicone film grafting 2-methacryloyloxyethyl phosphorylcholine onto silicone film to improve hemocompatibility显示文摘 | Yuan Y L Shan B | 2003 | Colloids and Surfaces B:Biointerfaces2003，30，： | 1 |
| 16 | Sol-gel preparation of BaTi4O9 and Ba2Ti9O20, 显示文摘 | Chen X M Wang L B | 2001 | Am Ceram Soc2001，84，3： | 1 |
| 17 | HIF-1alpha induced-VEGF overexpression in bone marrow stem cells protects cardiomyocytes against ischemia显示文摘 | Dai Y Xu M Wang Y | 2007 | J Mol Cell Cardiol2007，42，11： | 1 |
| 18 | Experimental seismic study of adjacent buildings with fluid dampers显示文摘 | Yang Z Xu Y L Asce M | 2003 | Journal of Structural Engineering/February2003，，： | 1 |
| 19 | Photoelectrochemical property and photocatalytic activity of N-dopod TiO2 nanotube arrays显示文摘 | Xu J J Ao Y H Chen M D Fu D G | 2010 | Applied Surface Science2010，256，13： | 1 |
| 20 | Application of artificial neural network to the detection of the transformer winding deformation 显示文摘 | Xu D K Fu C Z Li Y M | 1999 | IEE Conferenc Publication1999，，： | 1 |
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