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| 1 | Alcohol dehydrogenase: A potential new marker for diagnosis of intestinal ischemia using rat as a model显示文摘AIM: Intestinal ischemia (Ii) is an abdominal emergency due to blockade of the superior mesenteric artery resulting in 60-100% mortality if diagnosed late. Changes in several biochemical parameters such as D (-)-lactate, Creatinine kinase isoenzymes and lactate dehydrogenase suggested for early diagnosis, lack specificity and sensitivity. Therefore a biochemical parameter with greater sensitivity needs to be identified.METHODS: Wistar male rats were randomly assigned into two groups; control sham operated (n = 24) and ischemic test (n = 24) group. Superior mesenteric arterial occlusion was performed in the ischemic test group for 1 h. Alcohol dehydrogenase (ADH) was estimated in blood from portal vein, right ventricle of heart, dorsal aorta (DA) and inferior vena cava (IVC). The Serum glutamic acid pyruvate transaminase (SGPT) was also estimated in blood from portal vein and right ventricle of heart.RESULTS: A significant increase (P<0.001) in the levels of ADH in both portal blood as well as heart blood of the test group (232.72±99.45 EU and 250.85±95.14 EU, respectively)as compared to the control group (46.39±21.69 EU and 65.38±30.55 EU, respectively) were observed. Similarly,increased levels of ADH were observed in blood samples withdrawn from DA and IVC in test animals (319.52±80.14EU and 363.90±120.68 EU, respectively) as compared to the control group (67.68±63.22 EU and 72.50±58.45 EU,respectively). However, in test animals there was significant increase in SGPT in portal blood (P = 0.054) without much increase in heart blood.CONCLUSION: Significant increase in the levels of ADH in portal and heart blood within 1 h of SMA occlusion without increase in SGPT in heart blood, suggests that the origin of ADH is from ischemic intestine and not from liver. Similarly, raised ADH levels were found in DA and IVC as well. IVC blood does represent peripheral blood sample. A raised level of ADH in test animals confirms it to be a potential marker in the early diagnosis of Ii. | Upendra R Gumaste Mukund M Joshi Devendra T Mourya Pradip V Barde Ghanshyam K Shrivastav Vikram S Ghole | 2005 | World Journal of Gastroenterology2005，11，6： | 9 |
| 2 | Structure of a hyperthermophilic tungstopterin enzyme,aldehyde ferredoxin oxidoreductase显示文摘 | Chan M K Mukund S Kletzin A | 1995 | Science1995，267，5203： | 1 |
| 3 | Functional proper- ties of Rohu ( Labeo rohita) proteins during iced storage 显示文摘 | Mukund M Dhanya R Sankar T V | 2006 | Food Research International2006，39，8： | 1 |
| 4 | Purification and Characterization of Two Functional Forms of Intracellular Protease PfpI from the Hyperthermophilic Archaeon Pyrococcus furiosus显示文摘 | Halio S B Bauer M W Mukund S | 1997 | Applied and Environmental Microbiology1997，63，1： | 1 |
| 5 | An axiomatization of event structures显示文摘 | Mukund M Thiagarajan P S | 1989 | Lecture Notes in Computer Science1989，405，： | 1 |
| 6 | Logical characterization of well branching event structures显示文摘 | Mukund M Thiagarajan P S | 1992 | Theoretical Computer Science1992，96，： | 1 |
| 7 | Novel methylcellulose-grafted-acrylamide/gelatin microspheres for controlled release of nifedipine 显示文摘 | Babu V R Kanth V R Mukund J M | 2010 | Journal of Ap- plied Polymer Science2010，115，6： | 1 |
| 8 | Impact toughness in AI-12Si and AI-12Si-3Cu cast alloys-Part l:Effect of process variables and microstructure 显示文摘 | Basavakumar K G Mukund P G Chakraborty M | 2008 | International Jour- nal of Impact Engineering2008，35，： | 1 |
| 9 | Structure of the Hyperthermophilic Tungstoprotein Enzyme Aldehyde Ferredoxin Oxidoreductase显示文摘 | Chan M K Mukund S K Adams M W W | 1995 | Science1995，26，： | 1 |
| 10 | Drilling of hybrid metal matrix composites-Workpiece surface integrity 显示文摘 | BASAVARAJAPPA S CHANDRAMOHAN G PRABU M MUKUND K ASHWIN M | 2007 | Int J Mach Tnols Manuf2007，47，： | 1 |
| 11 | Thiagarajan:A theory of regular MSC languages显示文摘 | Henriksen J G Mukund M Kumar K N | 2005 | Inf Comp2005，202，1： | 1 |
| 12 | Structure of a hyperthermophilic tungstopterin enzyme, aldehyde ferredoxin oxidoreductase显示文摘 | CHAN M K MUKUND S KLETZIN A | 1995 | Science1995，267，5203： | 1 |
| 13 | Characterization of a tungsten-iron-sulfur protein exhibiting novel spectroscopic and redox properties from the hyperthermophilic archaebacterium, pyrococcus furiosus显示文摘 | Mukund S Adams M W W | 1990 | J Biol Chem1990，265，11： | 1 |
| 14 | Purification and Characterization of Two Functional Forms of Intraeellular Protease PfpI from the Hyperthermophilie Arehaeon Pyrococcus furiosus 显示文摘 | Hallo S B Bauer M W Mukund S | 1997 | Applied and Environmental Microbiology1997，63，1： | 1 |
| 15 | Production of naringinase from a new soil isolate, Bacillus methylotrophicus: isolation, optimization and scale-up studies显示文摘 | Mukund P Belur PD Saidutta M | 2014 | Preparative Biochemistry and Biotechnology2014，44，2： | 1 |
| 16 | Structure of a hyperthermophilic tungstopterin enzyme, aldehyde ferredoxin oxidoreductase 显示文摘 | Chan M K Mukund S Kletzin A | 1995 | Science1995，267，： | 1 |
| 17 | Structure of a hyperthermophilic tungstopterin enzyme,aldehyde ferredoxin oxidoreductase显示文摘 | Chan M K Mukund S Kletzin A | 1995 | Science1995，267，5203： | 1 |
| 18 | Dry sliding wear behavior of AI 2219/SiCp-Gr hybrid metal matrix composites 显示文摘 | BASAVARAJAPPA S CHANDRAMOHAN G MUKUND K ASHWIN M PRABU M | 2009 | Journal of Materials Engineering and Performance2009，15，： | 1 |
| 19 | Purification and Characterization of Two Functional Forms of IntraceUular Protease PfpI fi:om the Hyperthermophilic Archaeon Pyrococcus furiosus显示文摘 | HALLO S B BAUER M W MUKUND S | 1997 | Applied and Environmental Microbiology1997，63，1： | 1 |
| 20 | Environmentally compatible next generation green energetic materials (GEMs)显示文摘 | Talawar M B Sivabalan R MukundanT etal | 2009 | Journal of Hazardous Materials2009，161，： | 1 |
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