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| 1 | Mannose-binding lectin and maladies of the bowel and liver显示文摘Mannose-binding lectin (MBL) is a pattern-recognition molecule that binds to characteristic carbohydrate mo-tifs present on the surface of many different pathogens. MBL binding stimulates the immune system via the lectin pathway of complement activation. In certain clinical situations, often characterized by pre-existing immune compromise, MBL deficiency increases the risk of infec-tious and other disease-specific complications. Many of the key pathogenic processes inherent to common gastroenterological diseases, such as infection, immuno-logical damage, and carcinogenesis, have been linked to MBL. This editorial reviews the biology of MBL, outlines key disease associations to document the breadth of influence of MBL, and finally, highlights the relevance of MBL to both gastroenterological health and disease. | Daniel L Worthley Peter G Bardy David L Gordon Charles G Mullighan | 2006 | World Journal of Gastroenterology2006，12，40： | 2 |
| 2 | Advances in the genetics of high-riskchildhood B-progenitor acute lymphoblastic leukemia and juvenilemyelomonocytic leukemia:implications for therapy 显示文摘 | Loh M L Mullighan C G | 2012 | ClinCancer Res2012，18，10： | 1 |
| 3 | Outcome modeling with CRLF2, IKZF1, JAK, and minimal residual disease in pe- diatric acute lymphoblastic leukemia: a Children' s Ontology Group study显示文摘 | Chen IM Harvey RC Mullighan CG | 2012 | Blood2012，119，15： | 1 |
| 4 | Early T-cell precursor leukemia: a subtype of very high-risk acute lymphoblastic leukemia identified in two independent cohorts 显示文摘 | Coustan-Smith E Mullighan CG Onciu M | 2009 | Lancet Oncal2009，10，6： | 1 |
| 5 | JAK mutations in high - risk childhood acute lymphoblastic leukemia显示文摘 | Mullighan C G Zhang J Harvey R C | 2009 | Proc Natl Acad Sci U S A2009，106，23： | 1 |
| 6 | Acute lymphoblastic leukaemia显示文摘 | Inaba H Greaves M Mullighan CG | 2013 | Lancet2013，381，9881： | 1 |
| 7 | Pediatric acute myeloid leukemia with NPM1 mutations is characterized by a gene expre ssion profile with dysregulated HOX gene expression distinct from MLL-rearranged leukemias 显示文摘 | Mullighan C Kennedy A Zhou X | 2007 | Leukemia2007，21，9： | 1 |
| 8 | Early T-cell precursor leukaemia: a subtype of very high-risk acute lymphoblastic leukaemia 显示文摘 | Coustan-Smith E Mullighan CG Onciu M | 2009 | Lancet Oncol2009，10，2： | 1 |
| 9 | Fas gene promoter poly- morphisms in primary Sjogren' s syndrome 显示文摘 | Mullighan CG Heatley S Lester S | 2004 | Ann Rheum Dis2004，63，1： | 1 |
| 10 | Pediatric acute lymphoblastic leukemia:where are we going and how do we get there显示文摘 | Pui CH Mullighan CG Evans WE | | 0，，06： | 1 |
| 11 | Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia显示文摘 | Mullighan CG Su X Zhang J | | 0，，05： | 1 |
| 12 | Pediatric acutc lymphoblastie leukemia: where are we going and how do we get there? 显示文摘 | Pui C H Mullighan C G Evans W E | 2012 | Blood2012，120，6： | 1 |
| 13 | Mannose binding lectin polymorphisms are associated with early age of disease onset and autoimmunity in common variable immunodeficiency显示文摘 | Mullighan CG Marshall SE Welsh KI | 2000 | Scand J Immunol2000，51，2： | 1 |
| 14 | Mannose binding lectin polymorphisms are associated with age of disease onset and autoimmunity in common variable immunodeficiency显示文摘 | Mullighan C G Maphall S E Welsh K I | 2000 | Scand J Immunol2000，51，2： | 1 |
| 15 | BCR-ABL1 lymphoblastic leukaemia is characterized by the deletion of Ikaros显示文摘 | Mullighan CG Miller CB Phillips LA | | 0，，7191： | 1 |
| 16 | Acute lymphoblastie leukemia in children显示文摘 | Hunger SP Mullighan CG | 2015 | N Engl J Med2015，373，16： | 1 |
| 17 | Evolution of human BCR-ABL1 lymphoblastic leukaemia-initiating cells显示文摘 | Notta F Mullighan CG Wang JC | 2011 | Nature2011，469，7330： | 1 |
| 18 | Tumour necrosis factor and lymphotoxin-αpolymorphisms associated with common variable immunodeficiency: Role in the pathogenesis of granulomatous disease 显示文摘 | Mullighan CG Fanning CC Chapel HM | 1997 | Immunol1997，159，： | 1 |
| 19 | Pediatric acute lymphoblastic leukemia: where are we going and how do we get there显示文摘 | Pui CH Mullighan CG Evans WE | 2012 | Blood2012，120，6： | 1 |
| 20 | Evolution of human BCR-ABL1 lymphoblasfic leukaemia-initiating cells显示文摘 | Notta F Mullighan CG Wang JC | 2011 | Nature2011，469，7330： | 1 |
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