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| 1 | Interleukin-28 and hepatitis C virus genotype-4:Treatment-induced clearance and liver fibrosis显示文摘AIM:To investigate the association between interleukin-28B(IL28B) genotype and response to treatment and hepatic fibrosis in patients with hepatitis C virus(HCV) genotype 4.METHODS:Two hundred and one HCV-genotype 4 patients were included.All patients were treated with Peginterferon alph2a/Ribavirin for 48 wk.End of treatment response(ETR) was defined as loss of detectable serum HCV RNA at the end of treatment.Sustained viral response(SVR) was defined as loss of detectable serum HCV RNA at the end of 24 wk follow up.Genotyping of IL28B rs12979860 was performed using the TaqMan assay.We used logistic regression to estimate the adjusted odds ratio(aOR) and 95%CI.RESULTS:The study included 201 HCV-genotype 4 patients.The majority of patients were men(89.6%),with a median age of 47 years,inter-quartile range(40-51).Approximately 62.5% of patients had ETR,and 49.6% had SVR.Individuals who achieved SVR were more likely to be younger(χ 2 = 4.91,P = 0.027),and less likely to have fibrosis(χ 2 = 15.54,P < 0.0001),or inflammation(χ 2 = 7.58,P = 0.006).The genotype distribution of rs12979860 was 36.2%,49.0% and 14.8% for genotypes CC,CT,and TT,respectively.In these participants,rs12979860 genotype distribution did not differ by gender(P = 0.466),pretreatment viral load(P = 0.600),inflammation(P = 0.435),or fibrosis(P = 0.291).The frequencies of IL28B rs12979860 genotypes were TT(14.8%),CT(49.0%),and CC(36.2%).Compared to rs12979860 genotype TT,aORs(95%CI) for ETR and SVR were:CC genotype,[17.55(5.34-57.69) and 5.92(2.09-16.76),respectively];CT genotype,[5.15(1.80-14.78) and 2.48(0.94-6.52),respectively].In the current study,the patients who did not achieve ETR or SVR had a lower prevalence of rs12979860 CC(17.4% and 23.3%,respectively) than individuals who had ETR or SVR(47.9% and 47.2%,respectively).Individuals with rs12979860 CC genotype had approximately 6 times the odds of SVR compared to individuals with TT genotype(aOR = 5.92;95%CI:2.09-16.76).Similarly,patients with CT genotype had SVR more often than patients with TT genotype(aOR = 2.48;95%CI:0.94-6.52).Carrying at least one copy of the C allele(genotypes CT and CC) had almost 8 times the probability of ETR compared to those with genotype rs12979860 TT(aOR = 7.87;95%CI:2.84-21.82),and approximately 3 times the odds of SVR compared to those with genotype rs12979860 TT(aOR = 3.46;95%CI:1.37-8.74).In addition,data were consistent with a significant gene-dose relationship(aOR = 4.05/allele;95%CI:2.27-7.22).The association between rs12979860 genotype and SVR was similar among those who achieved and those who did not achieve SVR.CONCLUSION:In HCV-genotype 4 patients,rs12979860 is a sensitive predictor of viral clearance,independent of viral load,age,gender or fibrosis,with no similar relation to severity of fibrosis. | Moutaz Derbala Nasser Rizk Fatima Shebl Saad Alkaabi Nazeeh Eldweik Anil John Manik Sharma Rafie Yaqoob Muneera Almohanadi Mohammed Butt Khaled Alejji | 2012 | World Journal of Gastroenterology2012，18，47： | 2 |
| 2 | A simple and rapid high-performance liquid chromatographic method for the determination of bisoprolol fumarate and hydrochlorothiazide in a tablet dosage form显示文摘 | Shaikh S Thusleem OA Muneera MS | | 0，，03： | 1 |
| 3 | The Syndrome of Microcornea, Myopic Chorioretinal Atrophy, and Telecanthus ( MMCAT ) Is Caused by Mutations in ADAMTS18显示文摘 | Mohammed A. Aldahmesh Muneera J. Alshammari Arif O. Khan Jawahir Y. Mohamed Fatimah A. Alhabib Fowzan S. Alkuraya | 2013 | Human Mutation2013，，9： | 1 |
| 4 | Synthesis and characterization of polyurethane/ polybutyl methacrylate interpenetrating polymer networks 显示文摘 | MUNEERA B SIDDARAMAIAH | 2004 | Journal of Materials Science2004，39，： | 1 |
| 5 | Penetrating Keratoplasty in Eyes with Keratoconus and Vernal Keratocon junctivitis显示文摘 | Mahmood Muneera A Wagoner Michael D | 2000 | Cornea2000，19，4： | 1 |
| 6 | Typical and atypical aortic dissection: helical CT diagnosis 显示文摘 | MUNEERA A TALAAT Y ABBAS H | 2002 | Kuwait Medical Journal2002，34，1： | 1 |
| 7 | A simple RP-HPLC method for the simultaneous quantitation of chlorocresol,mometasone furnate,and fusidie acid in creams显示文摘 | Shaikh S Muneera MS Thusleem OA | 2009 | J Chromatogr Sci2009，47，2： | 1 |
| 8 | Modified Prosthetic Vascular Conduits显示文摘 | Muneera R Daniel A Melina R | 2008 | Circulation2008，117，： | 1 |
| 9 | Thermal and Structural Study of Mono- and Multi-Layered Thin Films Composed of CuAlS_(2) Chalcogenide显示文摘Thin films constituted of CuAlS_(2) nanoparticles deposited with various deposition velocities in single and multilayers onto silicon Si(111)substrates by thermal evaporation have been studied by lifting their structural and thermal properties.Thermal properties of Si(111)and Si(111)/CuAlS_(2) structures are determined by using the photothermal deflection technique by comparing experimental and theoretical signals.We succeed in extracting the thermal conductivity,the thermal diffusivity,and the electron free mean path of these deposited chalcogenide layers.For the multilayers,the obtained values of the thermal conductivity are in good agreement with the theoretical data. | Taher Ghrib Rawdha Brini Amel Lafi Al-otaibi Muneera Abdullah Al-messiere | 2013 | Chinese Physics Letters2013，30，10： | 0 |
| 10 | 直肠脱垂修补术应用于男性患者是安全的,但疗效仍不明确显示文摘背景:直肠脱垂在男性中少见,其治疗也鲜有文献报道。本研究旨在评估直肠脱垂修补术应用于男性的手术方式及疗效。方法:本研究为多中心回顾性分析,研究对象为2004-2014年间接受直肠脱垂修补术的连续男性病例。对手术方式及疗效(包括勃起功能和排粪功能)进行评估。结果:58例行直肠脱垂修补术的男性患者纳入研究,手术时平均年龄(52.7624.1)岁。随访时间0.5-117(平均13.2)月。大多数患者进行了内镜评估(78%),仅有少数患者接受了肛门动力学检测(16%)、排粪造影(9%)或直肠超声检查(3%)。10例(17%)患者在修补手术前接受了生物反馈/盆底生理治疗。19例(33%)患者行经会阴修补术(多为经会阴直肠乙状结肠切除术);39例(67%)行经腹修补术(均为缝扎固定术),其中77%采用微创技术完成。总并发症发生率为26%,其中尿潴留发生率为16%[经会阴手术较经腹手术更为常见(32%vs 8%,P=0.028)],尿路感染发生率7%,切口感染发生率3%。术后总体复发率为9%,但经腹与经会阴手术复发率的差异无统计学意义。大多数患者性功能方面的信息缺失,无论是手术前(76%)还是手术后(78%)。结论:直肠脱垂修补术应用于男性患者是安全的,且术后复发率低。但各个中心都没有能做好性功能方面的信息采集。进一步研究需要评估男性直肠脱垂的最佳修补术式以及功能学结果。 | Vitaliy Y.Poylin Jennifer L.Irani Reza Rahbar Muneera R.Kapadia | 2019 | Gastroenterology Report2019，7，4： | 0 |
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