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| 1 | Interfacial dislocation networks strengthening a fourth-generation single-crystal TMS-138 superalloy显示文摘 | J. X. Zhang T. Murakumo Y. Koizumi T. Kobayashi H. Harada S. Masaki | 2002 | Metallurgical and Materials Transactions A2002，，12： | 3 |
| 2 | The effects of ruthenium on the phase stability of fourth generation Ni-base single crystal superalloys显示文摘 | Atsushi Sato Hiroshi Harada Tadaharu Yokokawa Takao Murakumo Yutaka Koizumi Toshiharu Kobayashi Hachiro Imai | 2006 | Scripta Materialia2006，，9： | 1 |
| 3 | RET and neuroendocrine tumors显示文摘 | Masatoshi Ichihara Yoshiki Murakumo Masahide Takahashi | 2003 | Cancer Letters2003，，： | 1 |
| 4 | Cytopathic effects and local immune responses in repeated neoadjuvant HSV-tk+ ganciclovir gene therapy for prostate cancer显示文摘Objective:Cytopathic effects and local immune response were analyzed histologically in prostatic cancer(PCa)with in situ herpes simplex virus-thymidine kinase(HSV-tk)/ganciclovir(GCV)gene therapy(GT).Methods:Four high-risk PCa patients who received HSV-tk/GCV GT were investigated.After two cycles of intraprostatic injection of HSV-tk and administration of GCV,radical prostatectomy was performed.Formalin-fixed,paraffin-embedded sections were evaluated using immunohistochemistry.PCa with hormone therapy(HT,n=3)or without neoadjuvant therapy(NT,n=4)that were equivalent in terms of risk were also examined as reference.Immunoreactively-positive cells were counted in at least three areas in cancer tissue.Labeling indices(LI)were calculated as percentage values.Results:ssDNA LI in GT increased,indicating apoptosis,as well as tumor-infiltrating lymphocytes and CD68-positive macrophages,compared with their biopsies.GT cases showed significantly higher numbers of single-stranded DNA(ssDNA)LI,CD4/CD8-positive T cells and CD68-positive macrophages including M1/M2 macrophages than HT or NT cases.However,there was no significant difference in CD20-positive B cells among the types of case.There were strong correlations between CD8+T cells and CD68+macrophages(ρ=0.656,p<0.0001)as well as CD4+T cells and CD20+B cells(ρ=0.644,p<0.0001)in PCa with GT.Conclusions:Enhanced cytopathic effect and local immune response might be indicated in PCa patients with HSV-tk/GCV gene therapy. | Nobuyuki Yanagisawa Takefumi Satoh Ken-ichi Tabata Hideyasu Tsumura Yasutomo Nasu Masami Watanabe Timothy C.Thompson Isao Okayasu Yoshiki Murakumo Shiro Baba Masatsugu Iwamura | 2021 | Asian Journal of Urology2021，8，3： | 1 |
| 5 | Up-regulation of CD109 expression is associated with carcinogenesis of the squamous epithelium of the oral cavity显示文摘 | Hagiwara S Murakumo Y Sato T | 2008 | Cancer Sei2008，99，10： | 1 |
| 6 | Creep behaviour of Ni-base single-crystal superalloys with various T' volume fraction 显示文摘 | Murakumo T Kobayashi T Koizumi Y | 2004 | Acta Materialia2004，52，12： | 1 |
| 7 | Dependence of creep strength on the interracial dislocations in a fourth generation SC superalloy TMS-138显示文摘 | ZHANG J X MURAKUMO T HARADA H KOIZUMI Y | 2003 | Scripta Materialia2003，48，3： | 1 |
| 8 | High-level expression ofCD109 is frequently detected in lung squamous cell carcinomas显示文摘 | Sato T Murakumo Y Hagiwara S | 2007 | Pathol Int2007，57，11： | 1 |
| 9 | A human REV7 homolog that interacts with the polymerase zeta catalytic suhunit hREV3 and the spindle assembly checkpoint protein hMAD2 显示文摘 | Murakumo Y Roth T Ishii H | 2000 | J Biol Chem2000，275，6： | 1 |
| 10 | CD109 expression in bas-al-like breast carcinoma显示文摘 | Hasegawa M Moritani S Murakumo Y | 2008 | Pathol Int2008，58，5： | 1 |
| 11 | Structural changes of collagen components and diminution of nerves in congenital ureteropelvic junction obstruction显示文摘 | Murakumo M Nonomura K Yamashita T | 1997 | J Urol1997，157，5： | 1 |
| 12 | The effect of ruthenium on the phase stability of fourth generation Ni-base single crystal superalloys 显示文摘 | SATO A HARADA H YOKOKAWA T MURAKUMO T KOIZUMI Y KOBAYASHI T IMAI H | 2006 | Scripta Materialia2006，54，： | 1 |
| 13 | up - regulation of cdl09 expression is associated with carcinogenesis of the squamous epithelium of the oral cavity 显示文摘 | Hagiwara S Murakumo Y Sato T | 2008 | Cancer Sci2008，99，0： | 1 |
| 14 | The influence of interfacial dislocation arrangements in a fourth generation single crystal TMS-138 superalloy on creep properties 显示文摘 | ZHANG J X MURAKUMO T KOIZUMI Y HARADA H | 2003 | Journal of Materials Science2003，38，： | 1 |
| 15 | Creep Behaviour of Ni-Base Single-Crystal Superalloys With Various F'Volume Fraction显示文摘 | Takao Murakumo Toshiharu Kobayashi | 2004 | Acta Mater2004，52，： | 1 |
| 16 | RET and neuroendocrine tumors 显示文摘 | Murakumo Y Jijiwa M Asai N | 2006 | Pituitary2006，9，： | 1 |
| 17 | Creep behaviour of Ni-base single-crystal superalloys with various y' volume fraction显示文摘 | MURAKUMO T KOBAYASHI T KOIZUMI Y HARADA H | 2004 | Acta Materialia2004，52，12： | 1 |
| 18 | Cys611Ser mu-tation in RET proto-oncogene in a kindred with medullarythyroid carcinoma and Hirschsprung's disease 显示文摘 | Nishikawa M Murakumo Y Imai T | 2003 | Eur JHum Genet2003，11，5： | 1 |
| 19 | Structural changes of collagen components and diminution of nerves in congenital ureteropelvic junction obstruction显示文摘 | Murakumo M Nonomura K Yamashita T | 1997 | J Urol1997，157，5： | 1 |
| 20 | High-level expression of CD109 is frequently detected in lung squamous cell carcinomas显示文摘 | Sato T Murakumo Y Hagiwara S | 2007 | Pathol Int2007，57，11： | 1 |
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