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| 1 | Intensified intensity-modulated radiotherapy in anal cancer with prevalent HPV p16 positivity显示文摘AIM: To investigate the toxicity and response of intensity-modulated radiotherapy schedule intensified with a simultaneous integrated boost in anal canal cancer.METHODS: From March 2009 to March 2014, we retrospectively analyzed 41 consecutive patients treated with intensity-modulated radiotherapy(IMRT) and concurrent chemotherapy for anal canal squamous cell carcinoma at our center. Radiotherapy was delivered via simultaneous integrated boost(SIB) technique by helical tomotherapy, and doses were adapted to two clinical target volumes according to the tumor-nodemetastasis(TNM) stage: 50.6 Gy and 41.4 Gy in 23 fractions in T1N0, 52.8 Gy and 43.2 Gy in 24 fractionsin T2N0, and 55 Gy and 45 Gy in 25 fractions in all patients with N positive and/or ≥ T3, respectively, to planning target volumes 1 and 2. The most common chemotherapy regimen was 5-fluorouracil and mitomycin-based. Human papilloma virus(HPV) p16 expression was performed by immunohistochemistry and evaluated in the majority of patients. Acute and late toxicity was scored according to CTCAe v 3.0 and RTOG scales.RESULTS: The median follow-up was 30 mo(range:12-71). Median age was 63 years(range 32-84). The stage of disease was: stage Ⅰ in 2 patients, stage Ⅱin 13 patients, stage ⅢA in 12 patients, and stage ⅢB in 14 patients, respectively. Two patients were known to be HIV positive(4.9%). HPV p16 expression status was positive in 29/34(85.3%) patients. The 4-year progression-free survival and overall survival in HPVpositive patients were 78% and 92%, respectively.Acute grade 3 skin and gastrointestinal toxicities were reported in 5% and 7.3% of patients, respectively;patients' compliance to the treatment was good due to a low occurrence of severe acute toxicity, although treatment interruptions due to toxicity were required in 7.3% of patients. At 6 mo from end of treatment,36/40(90%) patients obtained complete response;during follow-up, 5(13.8%) patients presented with disease progression(local or systemic).CONCLUSION: In our experience, intensified SIBIMRT with chemotherapy is very feasible in clinical practice, with excellent results in terms of overall survival and local control. | Liliana Belgioia Stefano Vagge Dario Agnese Stefania Garelli Roberto Murialdo Giuseppe Fornarini Silvana Chiara Fabio Gallo Almalina Bacigalupo Renzo Corvò | 2015 | World Journal of Gastroenterology2015，21，37： | 2 |
| 2 | Clinical and diagnostic aspects of encephalopathy associated with autoimmune thyroid disease (or Hashimoto’s encephalopathy)显示文摘 | Gianluca Tamagno Giovanni Federspil Giovanni Murialdo | 2006 | Internal and Emergency Medicine2006，，1： | 1 |
| 3 | Gemcitabine and carboplatintreatment in advanced?NSCLC:a retrospective evaluation including elderly? patients显示文摘 | Murialdo R Boy D Bertolotti F | | 0，，01： | 1 |
| 4 | Relationship between cognitive function,growth hormone and insulin-like growth factor I plasma levels in aged subjects显示文摘 | Rollero A Murialdo G Fonzi S | 1998 | Neuropsychobiology1998，38，： | 1 |
| 5 | Clinical and diagnostic aspects of encephalopathy associated with autoimmune thyroid disease(or Hashimoto's encephalopathy)显示文摘 | Tamagno G Federspil G Murialdo G | 2006 | Intern Emerg Med2006，1，1： | 1 |
| 6 | Squamous cell carcinoma of the breast: a case report 显示文摘 | Murialdo R Boy D Musizzano Y | 2009 | Cases J2009，2，： | 1 |
| 7 | Effects of valproste,Phenobarbital and carbamazepine on sex steroid setup in woman with epilepsy显示文摘 | Murialdo G Galimberti C Rollero A | | 0，，： | 1 |
| 8 | Clinical and diagnostic aspects of encephalopathy associated with autoimmune thyroid disease (or Hashimoto's encephalopathy)显示文摘 | Tamagno G Federspil G Murialdo G | 2006 | Intern Emerg Med2006，1，1： | 1 |
| 9 | Effects of valproate,phenebarbial,and carbamazepine on sex steroid setup in women with epilepsy显示文摘 | Murialdo G Galimberti CA Giarelli MV | 1998 | Clin Neurophamacol1998，21，： | 1 |
| 10 | Central and Peripheral Nervous System Complications Following Allogeneic Bone Marrow Transplantation显示文摘 | Solaro C Murialdo A Giunti D | 2001 | Eur J Neurol2001，8，1： | 1 |
| 11 | Basiliximab is effective for erosive lichen planus显示文摘 | Rebora A Parodi A Murialdo G | 2002 | Arch Dermatol2002，138，8： | 1 |
| 12 | Nematodes as indicators of wetland pollution 显示文摘 | Murialdo S E Fuertes M G Gonzalez J F Chavez E | 2002 | J Envi- ron Biol2002，23，4： | 1 |
| 13 | Squamous cell carcinoma of the breast : a case report 显示文摘 | Murialdo R Boy D Musizzano Y | 2009 | Cases J2009，2，： | 1 |
| 14 | Relationships be- tween cortisol, dehydroepiandrosterone sulphate and insulin- like growth factor-I system in dementia显示文摘 | Murialdo G Barreca A Nobili F | 2001 | J Endocrinol In- vest2001，24，3： | 1 |
| 15 | Effects of valproate, phenobarbital and carbamazepine on sex steroid setup in women with epilepsy显示文摘 | Murialdo G Galimberti CA Gianelli MV | 1998 | Clin Neuropharmacol1998，21，： | 1 |
| 16 | Analysis of cosmids using linearization by phage lambda terminase 显示文摘 | Rackwitz HR Zehetner G Murialdo H | 1985 | Gene1985，40，23： | 1 |
| 17 | Clinical and diagnostic aspects of eneephalopathy associated with autoimmune thyroid disease (or Hashimoto's encephalopathy) 显示文摘 | Tamagno G Federspil G Murialdo G | 2006 | Intern Emerg Med2006，1，1： | 1 |
| 18 | Leiomyosareoma of the broad ligament: a case report and review of literature显示文摘 | Murialdo R Usset A Guido T | 2005 | Int J Gynecol Cancer2005，15，6： | 1 |
| 19 | Squamous cell carcinoma of the breast: a case report显示文摘 | Murialdo R Boy D Musizzano Y | 2009 | CasesJ2009，2，： | 1 |
| 20 | Bacteriophage lambda DNA: the beginning of the end显示文摘 | Becker A Murialdo H | 1990 | J Bacteriol1990，172，6： | 1 |
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