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| 1 | Software for automated classification of probe-based confocal laser endomicroscopy videos of colorectal polyps显示文摘AIM:To support probe-based confocal laser endomi-croscopy (pCLE) diagnosis by designing software for the automated classification of colonic polyps. METHODS:Intravenous fluorescein pCLE imaging of colorectal lesions was performed on patients under-going screening and surveillance colonoscopies, followed by polypectomies. All resected specimens were reviewed by a reference gastrointestinal pathologist blinded to pCLE information. Histopathology was used as the criterion standard for the differentiation between neoplastic and non-neoplastic lesions. The pCLE video sequences, recorded for each polyp, were analyzed off-line by 2 expert endoscopists who were blinded to the endoscopic characteristics and histopathology. These pCLE videos, along with their histopathology diagnosis, were used to train the automated classification software which is a content-based image retrieval technique followed by k-nearest neighbor classification. The performance of the off-line diagnosis of pCLE videos established by the 2 expert endoscopists was compared with that of automated pCLE software classification. All evaluations were performed using leave-one-patient- out cross-validation to avoid bias. RESULTS:Colorectal lesions (135) were imaged in 71 patients. Based on histopathology, 93 of these 135 lesions were neoplastic and 42 were non-neoplastic. The study found no statistical significance for the difference between the performance of automated pCLE software classification (accuracy 89.6%, sensitivity 92.5%, specificity 83.3%, using leave-one-patient-out cross-validation) and the performance of the off-line diagnosis of pCLE videos established by the 2 expert endoscopists (accuracy 89.6%, sensitivity 91.4%, specificity 85.7%). There was very low power (< 6%) to detect the observed differences. The 95% confidence intervals for equivalence testing were:-0.073 to 0.073 for accuracy, -0.068 to 0.089 for sensitivity and -0.18 to 0.13 for specificity. The classification software proposed in this study is not a 'black box' but an informative tool based on the query by example model that produces, as intermediate results, visually similar annotated videos that are directly interpretable by the endoscopist. CONCLUSION:The proposed software for automated classification of pCLE videos of colonic polyps achieves high performance, comparable to that of off-line diagnosis of pCLE videos established by expert endoscopists. | Barbara André Tom Vercauteren Anna M Buchner Murli Krishna Nicholas Ayache Michael B Wallace | 2012 | World Journal of Gastroenterology2012，18，39： | 5 |
| 2 | Structure of turbulent boundary layers at low Reynolds numbers显示文摘 | Murlis J Tsai H M Bradshaw P | 1998 | Fluid Mech1998，72，9： | 1 |
| 3 | The structure of turbulent boundary layers at low Reynolds number显示文摘 | MURLIS J TSAI H M and BRADSHAW P | 1982 | Journal of Fluid Mechanics1982，122，： | 1 |
| 4 | Integration of Pig-a,micronucleus,chromosome aberration,and Comet assay endpoints in a 28-day rodent toxicity study with 4-nitroquinoline-1-oxide显示文摘 | Stankowski LF Jr Roberts DJ Chen H Lawlor T Mc Keon M Murli H | 2011 | Environ Mol Mutagen2011，52，9： | 1 |
| 5 | Well-posed anisotropic diffusion for image denoising显示文摘 | V De Simone Murli A | 2002 | IEEE Image Signal Process2002，149，4： | 1 |
| 6 | Targeting caspases in cancer therapeutics显示文摘 | Patrick H Murli M Natasha K | 2013 | J Biol Chem2013，394，7： | 1 |
| 7 | Development of an efficient grain refiner for Al-TSi and its modification with stronlium显示文摘 | Kori S A Murly B S Chalcrahorly M | 2000 | Materials Science and Engineering2000，283，： | 1 |
| 8 | Phase transitions in Sc2(WO4)3 under high pressure显示文摘 | Nandini Garg Chitra Murli A K Tyagi Surinder M Sharma | 2005 | Physical Review2005，72，0641： | 1 |
| 9 | Well-posed anisotropic diffusion for image denoising 显示文摘 | Ceccarelli M Simone V Murli A | 2002 | IEEE Transactions on Image and Signal Processing2002，149，4： | 1 |
| 10 | The structure of turbulent boundary layers at low Reynolds numbers显示文摘 | MURLIS J TSAI H M BRADSHAW P | 1982 | Journal of Fluid Mechanics1982，122，： | 1 |
| 11 | Well-posed anisotropic diffusion for image denoising 显示文摘 | CECCARELLI M SIMONE V MURLI A | 2002 | IEEE Transactions on Image and Signal Processing2002，149，4： | 1 |
| 12 | The structure of turbulent boundary layers at low reynolds number 显示文摘 | Murlis J Tsai H M Bradshaw P | 1982 | Journal of Fluid Mechanics1982，122，： | 1 |
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