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| 1 | Clinical utility of the platelet-lymphocyte ratio as a predictor of postoperative complications after radical gastrectomy for clinical T2-4 gastric cancer显示文摘AIM To identify simple and sensitive markers for postoperative complications after gastrectomy, the predictive values were compared among candidate preoperative factors. METHODS Three-hundred and twelve patients with previously untreated clinical T2-4 gastric cancer who underwent a D2 standard gastrectomy(distal gastrectomy or total gastrectomy) were included in the analysis.Correlations between 21 parameters that can be determined by preoperative routine blood tests and clinically relevant postoperative complications(grade Ⅱ or higher according to the Clavien-Dindo classification) were evaluated. The optimal cutoff values and clinical significance of the selected markers were further evaluated by subgroup analyses according to age, body mass index, operative procedure and clinical disease stage.RESULTS Sixty-six patients(21.1%) experienced grade Ⅱ or higher postoperative complications. The plateletlymphocyte ratio(PLR, total lymphocyte count/platelet count × 100) exhibited the highest area under the curve value(0.639) for predicting postoperative complications among the 21 parameters, and the optimal cutoff value was determined to be 0.71(sensitivity = 70%, specificity = 56%). In the univariate analysis, the odds ratio of a low PLR for the occurrence of postoperative complications was 2.94(95%CI: 1.66-5.35, P < 0.001), and a multivariate binomial logistic analysis involving other potential risk factors identified a low PLR as an independent risk factor for postoperative complications(OR = 3.32, 95%CI: 1.82-6.25, P < 0.001). In subgroups classified according to age, body mass index, operative procedure and clinical disease stage, the low PLR group exhibited an increased incidence of postoperative complications. CONCLUSION The preoperative PLR is a simple and useful predictor of complications after curative gastrectomy in patients with clinical T2-4 gastric cancer. | Kenichi Inaoka Mitsuro Kanda Hiroaki Uda Yuri Tanaka Chie Tanaka Daisuke Kobayashi Hideki Takami Naoki Iwata Masamichi Hayashi Yukiko Niwa Suguru Yamada Tsutomu Fujii Hiroyuki Sugimoto Kenta Murotani Michitaka Fujiwara Yasuhiro Kodera | 2017 | World Journal of Gastroenterology2017，23，14： | 13 |
| 2 | Comparison of PPIs and H_2-receptor antagonists plus prokinetics for dysmotility-like dyspepsia显示文摘AIM:To compare efficacy of proton pump inhibitors(PPIs)with H2-receptor antagonists(H2RAs)plus prokinetics(Proks)for dysmotility-like symptoms in functional dyspepsia(FD).METHODS:Subjects were randomized to receive openlabel treatment with either rabeprazole 10 mg od(n= 57)or famotidine 10 mg bid plus mosapride 5 mg tid(n=57)for 4 wk.The primary efficacy endpoint was change(%)from baseline in total dysmotility-like dyspepsia symptom score.The secondary efficacy endpoint was patient satisfaction with treatment.RESULTS:The improvement in dysmotility-like dyspep-sia symptom score on day 28 was significantly greater in the rabeprazole group(22.5%±29.2%of baseline) than the famotidine+mosapride group(53.2%± 58.6%of baseline,P<0.0001).The superior benefit of rabeprazole treatment after 28 d was consistent regardless of Helicobacter pylori status.Significantly more subjects in the rabeprazole group were satisfied or very satisfied with treatment on day 28 than in the famotidine+mosapride group(87.7%vs 59.6%,P= 0.0012).Rabeprazole therapy was the only significant predictor of treatment response(P<0.0001),defined as a total symptom score improvement≥50%.CONCLUSION:PPI monotherapy improves dysmotility-like symptoms significantly better than H2RAs plus Proks,and should be the treatment of first choice for Japanese FD. | Masahiro Sakaguchi Miyuki Takao Yasuo Ohyama Hiroshi Oka Hiroshi Yamashita Takumi Fukuchi Kiyoshi Ashida Masahiro Murotani Masuyo Murotani Kazuo Majima Hiroshi Morikawa Takashi Hashimoto Keisuke Kiyota Hirohiko Esaki Kanji Amemoto Gouhei Isowa Fumiyuki Takao | 2012 | World Journal of Gastroenterology2012，18，13： | 8 |
| 3 | Prognostic significance of perioperative tumor marker levels in stage Ⅱ/Ⅲ gastric cancer显示文摘AIM To evaluate the prognostic significance of perioperative carcinoembryonic antigen(CEA) and carbohydrate antigen 19-9(CA19-9) levels in stage Ⅱ/Ⅲ gastric cancer.METHODS From a multi-institutional retrospective database compiled by integrating clinical data from nine institutions, data of 998 patients who underwent curative resection for stage Ⅱ/Ⅲ gastric cancer between 2010 and 2014 were retrieved and analyzed. The prognostic impact of the preoperative and postoperative levels and chronological changes in CEA, CA19-9 and their combination were evaluated. To test whether postoperative adjuvant chemotherapy alters the prognostic impact of perioperative CEA and CA19-9 levels, the hazard ratios for mortality were compared between patients who underwent surgery alone and patients who underwent surgery followed by adjuvant chemotherapy.RESULTS The prognostic impact of postoperative CEA and CA19-9 was superior to that of the preoperative levels. Multivariable analysis identified high postoperative CEA and CA19-9 levels as independent prognostic factors for overall survival.Disease-free survival rates clearly decreased in a stepwise manner in association with postoperative CEA and CA19-9 levels, and patients with high levels of both markers showed significantly poorer prognosis than other patient groups. When we analyzed perioperative changes in serum CEA and CA19-9 levels, patients with high levels before and after surgery had the worst disease-free survival rates among all patient groups. Patients with normalized CEA levels after surgery had a significantly lower disease-free survival rate than those with normal perioperative levels, whereas patients with normalized CA19-9 levels after surgery had equivalent survival to those with normal perioperative levels. The prognostic impact of high CEA levels was observably smaller in patients who underwent adjuvant chemotherapy than in patients who underwent surgery alone, whereas that of high CA19-9 was greater in patients who underwent adjuvant chemotherapy. High postoperative CEA levels were significantly associated with an increased prevalence of liver, lung and bone recurrences, and high postoperative CA19-9 levels were significantly associated with increased frequencies of lymph node and liver recurrences.CONCLUSION The evaluation of serum CEA and CA 19-9 levels both before and after surgery provides useful information for precise risk stratification after curative gastrectomy. | Yasuhito Suenaga Mitsuro Kanda Seiji Ito Yoshinari Mochizuki Hitoshi Teramoto Kiyoshi Ishigure Toshifumi Murai Takahiro Asada Akiharu Ishiyama Hidenobu Matsushita Chie Tanaka Daisuke Kobayashi Michitaka Fujiwara Kenta Murotani Yasuhiro Kodera | 2019 | World Journal of Gastrointestinal Oncology2019，11，1： | 7 |
| 4 | Influence of substrate surface roughness on light scattering of TiO2 optical thin films显示文摘 | Toshinori Harada Hiroshi Murotani Shigeharu Matumoto Hiromitu Honda | 2013 | Chinese Optics Letters2013，11，13： | 2 |
| 5 | Behavioral abnormalities and dopamine reductions in sdy mutant mice with a deletion in Dtnbpl, a susceptibility gene for schizophrenia 显示文摘 | HATTORI S MUROTANI T MATSUZAKI S | 2008 | Biochem Biophys Res Commun2008，373，2： | 1 |
| 6 | Microwave Emission due to Hypervelocity Impacts and Its Correlation with Mechanical Destruction显示文摘 | Takano T Murotani Y Toda T | 2002 | J Appl Phys2002，92，9： | 1 |
| 7 | Comparison of air kerma between C-arm CT and 64-multidetector-row CT using a phantom显示文摘 | Seiki Hosokawa Nobuyuki Kawai Morio Sato Hiroki Minamiguchi Motoki Nakai Kazuhiro Murotani Tadayoshi Nishioku Shintaro Shirai Tetsuo Sonomura | 2014 | Japanese Journal of Radiology2014，，5： | 1 |
| 8 | Optical characteristics of Al2O3 ceramics doped with Cr at high concentrations prepared by extrusion molding process 显示文摘 | Murotani H Mituda T Wakaki M | 2000 | Jan J Appl Phy2000，39，： | 1 |
| 9 | Postoperative adjuvant chemotherapy with S-1 alters recurrence patterns and prognostic factors among patients with stage II/III gastric cancer: A propensity score matching analysis显示文摘 | Mitsuro Kanda Kenta Murotani Daisuke Kobayashi Chie Tanaka Suguru Yamada Tsutomu Fujii Goro Nakayama Hiroyuki Sugimoto Masahiko Koike Michitaka Fujiwara Yasuhiro Kodera | 2015 | Surgery2015，，6： | 1 |
| 10 | Microwave emission due to hypervelocity impact and its correlation with mechanical destruction显示文摘 | Takayo T Murotani Y Toda T | 2002 | J Appl Phys2002，92，9： | 1 |
| 11 | Optical characteristics of Al2O3 ceramics doped with Cr at high concentrations prepared by extrusion molding process显示文摘 | MUROTANI H MITUDA T WAKAKI M | 2000 | Jan J Appl Phy2000，39，： | 1 |
| 12 | Inverse Probability of Treat- ment Weighting Analysis of Upfront Surgery Versus Neoadjuvant Chemoradiotherapy Followed by Surgery for Pancreatic Adenocarcino- ma with Arterial Abutment 显示文摘 | Fujii T Yamada S Murotani K | 2015 | Medicine (Baltimore)2015，94，39： | 1 |
| 13 | Comparison of the international consensus guidelines for predicting malignancy in intraductal papillary mucinous neoplasms 显示文摘 | Yamada S Fujii T Murotani K | 2016 | Surgery2016，159，3： | 1 |
| 14 | Anodic polymerization of aromatic compounds in centrifugal fields显示文摘 | ATOBE M MUROTANI A HITOSE S | 2004 | Elentrochimica Acta2004，50，8： | 1 |
| 15 | 查看详情显示文摘 | Nakamura T Tamura A Murotani H | | 0，，05： | 1 |
| 16 | Optimal injection rate and volume of contrast medium for observing hemodynamics of a hepatocellular carcinoma structure model 显示文摘 | Murotani K Kawai N Sato M | 2013 | Radiol Phys Technol2013，6，1： | 1 |
| 17 | Optical Charac teristics of Al2O3 Ceramics Doped with Cr at High Concen trations Prepared by Extrusion Molding Process显示文摘 | Murotani H Mituda T Wakaki M | 2000 | Jpn J Appl Phy2000，39，： | 1 |
| 18 | Adverse events associated with intraocular injections of bevacizumab in eyes with neovascular glaucoma 显示文摘 | Higashide T Murotani E Saito Y Ohkubo S Sugiyama K | 2012 | Graefes Arch Clin Exp Ophthalmol2012，250，4： | 1 |
| 19 | The effects of combine treatment of memantine and donepezil on Alzheimer’s Disease patients and its relationship with cerebral blood flow in the prefrontal area显示文摘 | Tomoko Araki Rei Wake Tsuyoshi Miyaoka Kazunori Kawakami Michiharu Nagahama Motohide Furuya Erlyn Limoa Kristian Liaury Sadayuki Hashioka Kenta Murotani Jun Horiguchi | 2014 | Int J Geriatr Psychiatry2014，，9： | 1 |
| 20 | Outcomes of endoscopic endonasal dacryocysto-rhinostomy for intractable lacrimal dacryostenosis and associated factors显示文摘AIM:To examine the effects of patient age,canalicular obstruction,mode of anesthesia,and duration of nasolacrimal intubation on the outcomes of endoscopic endonasal dacryocystorhinostomy(DCR). METHODS: Totally 56 eyes of 46 patients with prolonged epiphora underwent minimally invasive endoscopic endonasal DCR.A successful surgical outcome was defined as a significant improvement in symptoms,adequate water passage from the puncta to the nasal cavity,and patency of the DCR ostium.All outcomes were assessed at least 6mo after extubation.Fisher's exact test was used to discuss the factors,and then the logistic regression analysis was made by SAS9.4 software.RESULTS: The overall success rate was 75.0%,and complete resolution was observed in 27 eyes.The success rate was higher for patients with ≥6mo intubation than for those with <6mo intubation.However,there were no significant differences in outcomes between groups stratified by age(<65 or ≥65y),presence or absence of canalicular obstruction,mode of anesthesia(local or general),and use or nonuse of a radiowave unit.One patient developed subcutaneous emphysema around the eye and nose and one developed subcutaneous hemorrhage after surgery. CONCLUSION: Endoscopic endonasal DCR can be considered safe and minimally invasive with reasonable success rates,particularly when the duration of nasolacrimal intubation is ≥6mo. | Tohru Tanigawa Hirokazu Sasaki Hiroshi Nonoyama Yuichiro Horibe Kunihiro Nishimura Tetsuro Hoshino Tetsuya Ogawa Kenta Murotani Hiromi Ueda Masahiro Kaneda | 2016 | International Journal of Ophthalmology(English edition)2016，9，10： | 1 |
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