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| 1 | Carbonic anhydrase enzymes Ⅱ, Ⅶ, Ⅸ and Ⅻ in colorectal carcinomas显示文摘AIM To investigate expression of four alpha-carbonic anhydrases(CAs) in colorectal carcinomas(CRC) and compare the results with patients' survival.METHODS Colorectal carcinoma samples from 539 CRC patients and control tissues were arranged as tissue microarrays and analyzed with antibodies against CA Ⅱ, CA Ⅶ, CA Ⅸ, and CA Ⅻ. Intensity and extent of staining were both scored from 0 to 3 in each sample. These enzyme expression levels were then correlated to patients' survival and clinicopathological parameters, which were tumor differentiation grade and stage, site of tumor, patients' age, and gender. Kaplan-Meier analysis and Cox regression hazard ratio model were used to analyze survival data. RESULTS CA Ⅱ and CA Ⅻ staining intensities correlated with patients' survival in that higher expression indicated poorer prognosis. In Cox regression analysis one unit increase in the CA Ⅱ intensity increased the hazard ratio to 1.19 fold(CI: 1.04-1.37, P = 0.009). A significant correlation was also found when comparing CA Ⅻ staining intensity with survival of CRC patients(HR = 1.18, 95%CI: 1.01-1.38, P = 0.036). The extent of CA Ⅻ immunostaining did not correlate to the patients' survival(P = 0.242, Kaplan-Meier analysis). A significant interaction between age group and extent of the CA Ⅱ staining was found. Increased extent of CA Ⅱ had a significant hazard ratio among patients 65 years and older(1.42, 95%CI: 1.16-1.73, P = 0.0006). No correlations were found between CA Ⅶ(intensity P = 0.566, extent P = 0.495, Kaplan-Meier analysis), or CA Ⅸ(intensity P = 0.879, extent P = 0.315, KaplanMeier analysis) immunostaining results and survival, or the other parameters. CONCLUSION The present findings indicate that CA Ⅱ and CA Ⅻ could be useful in predicting survival in CRC. | Pia Viikil? Antti J Kivel? Harri Mustonen Selja Koskensalo Abdul Waheed William S Sly Jaromir Pastorek Silvia Pastorekova Seppo Parkkila Caj Haglund | 2016 | World Journal of Gastroenterology2016，22，36： | 3 |
| 2 | Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development显示文摘 | Korhonen J Mustonen T | 1995 | Proc Natl Acad Sci USA1995，92，8： | 1 |
| 3 | MRI of acute meniscal injury associated with tibial plateau fractures : prevalence, type, and loca- tion显示文摘 | Antti OT Mustonen MP Koivikko J | 2008 | AJR Am J Roentgeno12008，191，4： | 1 |
| 4 | Hantavirus infectionin Europe显示文摘 | Vapalahti 0 Mustonen J Lundkvist A | 2003 | Lancet Infect Dis2003，3，0： | 1 |
| 5 | Segond fracture combined with tibial plateau fracture 显示文摘 | Peltola EK Mustonen AO Lindahl J et a/ | 2011 | AJR Am J ~Roentgenol2011，197，6： | 1 |
| 6 | Long-lived memory T lymphocyte responses after Hantavirus infection 显示文摘 | Terajima M Mustonen J | 2002 | J Exp Med2002，196，5： | 1 |
| 7 | Retinopay is independently related to microalbuminuria in type 2 diabetes mellitus显示文摘 | Wirta O Pasternack A Mustonen J | 1999 | Clin Nephrol1999，51，6： | 1 |
| 8 | Hypertriglyceridaemia and hyeruricaemia are risk factors for progression of IgA nephropathy 显示文摘 | Syrjanen J Mustonen J Pastemack A | 2000 | Nephrol Dial Transplant2000，15，1： | 1 |
| 9 | The pathogenesis of nephmpathia epidemica: new knowledge and unanswered questions 显示文摘 | Mustonen J Makela S Outinen T | 2013 | Antiviral Res2013，100，3： | 1 |
| 10 | Patients with acute pancreatitis complicated by organ dysfunction show abnormal peripheral blood polymorphonuclear leukocyte signaling显示文摘 | Oiva J Mustonen H Kylanpaa ML | 2013 | Pancreatology2013，13，2： | 1 |
| 11 | Hantavirus infections in Europe显示文摘 | Vapalaphti O Mustonen J Lundkvkist A | 2003 | Lancet Infect Dis2003，3，： | 1 |
| 12 | Hypertrigly ceridaemia and hyperuricaemia are risk factors for progression of IgA nephropat hy显示文摘 | Syrjanen J Mustonen J Pastermack A | 2000 | Nephrol Dial Transplant2000，15，1： | 1 |
| 13 | Expressionof the fms-like tyrosine kinase 4gene becomes restrictedto lymphatic endothelium during development显示文摘 | Kaipainen A Korhonen J Mustonen T | 1995 | ProcNatl Acad Sci U S A1995，92，8： | 1 |
| 14 | Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development 显示文摘 | Kaipainen A Korhonen J Mustonen T | 1995 | Proc Nad Acad Sci USA1995，92，8： | 1 |
| 15 | Expression of the fms-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development显示文摘 | Kaipainen A Korhonen J Mustonen T | 1995 | Proc Natl Acad Sci U S A1995，92，8： | 1 |
| 16 | Expression of the fins-like tyrosine kinase 4 gene becomes restricted to lymphatic endothelium during development显示文摘 | Kaipainen A Korhonen J Mustonen T | 1995 | Proc Natl Acad Sci USA1995，92，： | 1 |
| 17 | Cytokines, adhesion molecules, and cellular infiltration in nephropathia epidemica kidneys: an immunohistochemical study显示文摘 | Temonen M Mustonen J Helin H | 1996 | Clin Immunol Immunopathol1996，78，： | 1 |
| 18 | IgM nephropathy:clinical picture and long-term prognosis显示文摘 | Myllymaki J Saha H Mustonen J | 2003 | Am J Kidney Dis2003，41，2： | 1 |
| 19 | IgM-associated glomerulonephritis显示文摘 | Helin H Mustonen J Pasternack A | 1982 | Nephron1982，31，1： | 1 |
| 20 | Postopera tive MDCT of tibial plateau fractures显示文摘 | Mustonen AO Koivikko MP Kiuru M J e* al | 2009 | AJR Am J Ro- entgenol2009，193，5： | 1 |
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