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| 1 | Diet and epigenetics in colon cancer显示文摘Over the past few years, evidence has accumulated indicating that apart from genetic alterations, epigenetic alterations, through e.g. aberrant promoter methylation, play a major role in the initiation and progression of colorectal cancer (CRC). Even in the hereditary colon cancer syndromes, in which the susceptibility is inherited dominantly, cancer develops only as the result of the progressive accumulation of genetic and epigenetic alterations. Diet can both prevent and induce colon carcinogenesis, for instance, through epigenetic changes, which regulate the homeostasis of the intestinal mucosa. Food-derived compounds are constantly present in the intestine and may shift cellular balance toward harmful outcomes, such as increased susceptibility to mutations. There is strong evidence that a major component of cancer risk may involve epigenetic changes in normal cells that increase the probability of cancer after genetic mutation. The recognition of epigenetic changes as a driving force in colorectal neoplasia would open new areas of research in disease epidemiology, risk assessment, and treatment, especially in mutation carriers who already have an inherited predisposition to cancer. | Minna Nystrm Marja Mutanen | 2009 | World Journal of Gastroenterology2009，15，3： | 8 |
| 2 | Job dissatisfaction and work-related exhaustion in male and female work显示文摘 | Kaisa Kauppinen-Toropainen Irja Kandolin and Pertti Mutanen | 1983 | Journal of Occupational Behaviour1983，，3： | 1 |
| 3 | Similar effects of diets high in oleicor linoleic acids on coagulation and fibrinolytic factors in healthyhumans显示文摘 | TURPEINEN A MUTANEN M | 1999 | Nutrition Metabolism and Cardiovascular Diseases:NMCD1999，9，2： | 1 |
| 4 | Staying Well or Burning Out at Work:Work Characteristics and Personal Resources as Long-term Predictors显示文摘 | Kalimo R Pahkin K Mutanen P | 2003 | Work Stress2003，17，2： | 1 |
| 5 | Staying well or burning out at work:work characteristics and personal resources as long-term predictors显示文摘 | Kalimo R Pahkin K Mutanen P | 2003 | Work Stress2003，17，2： | 1 |
| 6 | Urinary hydroxy-metabolites of naphthalene, phenanthrene and pyrene as markers of exposure to diesel exhaust显示文摘 | Leea Kuusim?ki Yrj? Peltonen Pertti Mutanen Kimmo Peltonen Kirsti Savela | 2004 | International Archives of Occupational and Environmental Health2004，，1： | 1 |
| 7 | Gender specific incidence trends in lung cancer by histological type in Sweden,1958-1996显示文摘 | Li X Mutanen P Hemminki K | | 0，，03： | 1 |
| 8 | Bioavailability to rats of selenium in milk of cows fed sodium selenite or selenited barley显示文摘 | A spila P Mykkanen H M | 1986 | Ann Nutr1986，30，3： | 1 |
| 9 | Similar effects of diets high oleic or linoleic acids on coagulation and fibrinolytic fac-tors in healthy humans显示文摘 | Turpeinen AM Mutanen M | 1999 | Nutr Metab Cardiovasc Dis1999，9，： | 1 |
| 10 | Urinary hydroxy-metabolites of naphthalene, phenanthrene and pyrene as markers of exposure to diesel exhaust显示文摘 | Leea K Krjo P Mutanen P | 2004 | Int Arch Occup Environ Health2004，77，： | 1 |
| 11 | Antioxidant and Antitumor Effects of Hydroxymatairesinol (HM-3000, HMR), A Lignan Isolated From the Knots of Spruce显示文摘 | Saarinen N Mutanen M | 2002 | Eur J Cancer Prev2002，11，2： | 1 |
| 12 | Bioconversion of vaccenic acid to conjugated linoleic acid in humans 显示文摘 | TURPEINEN AM MUTANEN M ARO A | 2002 | Am J Clin Nutr2002，76，3： | 1 |
| 13 | Factors predictive of ischemic heart disease mortality in foundry workers exposed to carbon monoxide显示文摘 | KOSKELA R S MUTANEN P SORSA J A | 2000 | Am J Epidemiol2000，152，7： | 1 |
| 14 | Diet and epigenetics in colon cancer 显示文摘 | Nystrom M Mutanen M | 2009 | World J Gastroenterol2009，15，3： | 1 |
| 15 | Stearic acid,trans fatty acids,and dairy fat:effects on serum and lipoprotein lipids,apolipoprteins,lipoprotein(a),and lipid transfer proteins of heslthy subjects显示文摘 | Aro A Jauhiainen M Partanen R Salminen & Mutanen M | 1997 | American Journal of Clinical Nutrition1997，65，： | 1 |
| 16 | Factors predictive of ischemic heart disease mortality in foundry workers exposed to carbon monoxide显示文摘 | Koskela RS Mutanen P Sorsa JA | 2000 | Am J Epidemiol2000，152，： | 1 |
| 17 | Urinary-metabolites of naphthalene, phenanthrene and pyrene as biomarkers of exposure to diesel ex- haust 显示文摘 | KUUSIMAKI L PELTONEN Y MUTANEN P | 2004 | International Archives of Occupational and Environmental Health2004，77，： | 1 |
| 18 | ^32P-postlabelling determination of DNA adducts of malonaldehyde in humans: total white blood cells and breast tissue 显示文摘 | VACA C E FANG J L MUTANEN M | 1995 | Carcinogenesis1995，16，8： | 1 |
| 19 | Staying well or burning out at work:Work characteristics and personal resources as long-term predictors显示文摘 | Kalimo R Pahkin K Mutanen P | 2003 | Work Stress2003，17，2： | 1 |
| 20 | The process of burnout in white-collar and blue-collar jobs: Eight-year prospective study of exhaustion显示文摘 | Salla Toppinen-Tanner Raija Kalimo Pertti Mutanen | 2002 | Journal of Organizational Behavior2002，8，23： | 1 |
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