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| 1 | Colorectal cancer in patients under 50 years of age:A retrospective analysis of two institutions' experience显示文摘AIM:To investigate the epidemiological characteristics of colorectal cancer(CRC)in patients under 50 years of age across two institutions.METHODS:Records of patients under age 50 years of age who had CRC surgery over a 16 year period were assessed at two institutions.The following documents where reviewed:admission notes,operative notes,and discharge summaries.The main study variables included:age,presenting symptoms,family history,tumor location,operation,stage/differentiation of disease,and post operative complications.Stage of disease was classified according to the American Joint Committee on Cancer TNM staging system:tumor depth;node status;and metastases.RESULTS:CRC was found in 180 patients under age50 years(87 females,93 males;mean age 41.4±6.2years).Young patients accounted for 11.2%of cases during a 6 year period for which the full data set wasavailable.Eight percent had a 1stdegree and 12%a 2nd degree family CRC history.Almost all patients(94%)were symptomatic at diagnosis;common symptoms included:bleeding(59%),obstruction(9%),and abdominal/rectal pain(35%).Evaluation was often delayed and bleeding frequently attributed to hemorrhoids.Advanced stage CRC(Stage 3 or 4)was noted in 53%of patients.Most tumors were distal to the splenic flexure(77%)and 39%involved the rectum.Most patients(95%)had segmental resections;6 patients had subtotal/total colectomy.Poorly differentiated tumors were noted in 12%and mucinous lesions in 19%of patients of which most had Stage 3 or 4 disease.Twenty-two patients(13%)developed recurrence and/or progression of disease to date.Three patients(ages 42,42and 49 years)went on to develop metachronous primary colon cancers within 3 to 4 years of their initial resection.CONCLUSION:CRC was common in young patients with no family history.Young patients with symptoms merit a timely evaluation to avoid presentation with late stage CRC. | Elizabeth A Myers Daniel L Feingold Kenneth A Forde Tracey Arnell Joon Ho Jang Richard L Whelan | 2013 | World Journal of Gastroenterology2013，19，34： | 9 |
| 2 | 基于自动测量的诊室血压高血压诊断标准与心血管病风险显示文摘与血压相关的心血管事件风险很大程度是基于台式水银血压计的人群测量数据。考虑到电子血压计逐步替代台式水银血压计,该研究采用全自动血压计在研究对象独自安静休息时多次读取数据,以探讨导致心血管风险显著增加的血压水平。方法:纳入〉65岁的未经治疗的高血压社区居民3627例。从社区药店和家庭医生获得受试者未受干扰时的坐位自动诊室血压数据。针对致命性及非致命性心血管事件,受试者随访(4.9±1.0)年。 | Myers MG Kaczorowski J Paterson JM Dolovich L Tu K 赵狄 练桂丽 | 2015 | 中华高血压杂志2015，23，8： | 3 |
| 3 | Identification of a novel telomerase repressor that interacts with the human papillomavirus type-16 E6/E6AP complex 显示文摘 | Gewin L Myers H Kiyono T | 2004 | Genes Dev2004，18，18： | 1 |
| 4 | Multi grating quasi phase matched optical parametric oscillator in periodically poled LiNbOa显示文摘 | Myers L E Eckardt R C Fejer M M | 1996 | OptLett1996，21，8： | 1 |
| 5 | Quasi-phase-matched optical parametric oscillators in bulk periodically poled LiNbO3显示文摘 | R C Eckardt M M Fejer | 1995 | Journal of Optical Society of America B1995，12，11： | 1 |
| 6 | Bacterial vaginesis and susceptibility to HIV infection in South African women:a nested case-control study显示文摘 | Myer L Denny L Telerant R | 2005 | J Infect Dis2005，192，8： | 1 |
| 7 | Sleep apnea in patientsreceiving growth hormone显示文摘 | Gerard JM Garibaldi L Myers SE | 1997 | Clin Pediatr Phila1997，36，6： | 1 |
| 8 | Idiopathic pulmonary fibrosis:clinical relevance of pathologic classification显示文摘 | Katzenstein ALA Myers J L | 1998 | Am J Respir Crit Care Med1998，157，41： | 1 |
| 9 | Experimental studies of elastic-wave propagation in a columnar-jointed rock mass显示文摘 | King M S Myer L R Rezowalli J J | 1986 | Geophysical Prospecting1986，34，8： | 1 |
| 10 | NEMO Satellite Sensor Imaging Payload 显示文摘 | Myers W A Smith R D Stuart J L | 1998 | Proceeding of SPIE1998，3437，： | 1 |
| 11 | Gene expression of type I , nl and 1V collagens in hepatic fibrosis induced by dimethylni- trosamine in the rat显示文摘 | Ala-Kokko L Pihlajaniemi T Myers J C | 1987 | Biochem J1987，244，1： | 1 |
| 12 | Idiopathic pulmonary fibrosis: clinicalrelerace of pathologic classification显示文摘 | Katzenstein A L Myers J L | 1998 | Am J Respire Crit1998，157，4： | 1 |
| 13 | Time-lapse crosswell seismic and VSP monitoring of injected COe in a brine aquifer 显示文摘 | Daley T M Myer L R Peterson J E | 2008 | Environmental Geology2008，54，8： | 1 |
| 14 | Coupled Reservoir-Geome- chanical Analysis of CO2 Injection and Ground Deformations at In Salah, Algeria 显示文摘 | RUTQVIST J VASCO D W MYER L | 2010 | International Journal of Greenhouse Gas Con- trol2010，2，4： | 1 |
| 15 | Recommendations for improving serum creatinine measurement:a report from the Laboratory Working Group of the National Kidney Disease Education Program显示文摘 | Myers G L Miller W G Coresh J | | 0，，： | 1 |
| 16 | The exchange adsorption of ions from aqueous solutions by organic zeolitesⅡ:Kinetics显示文摘 | Boyd G E Adamson A W Myers L S | 1947 | Journal of the American Chemical Society1947，69，11： | 1 |
| 17 | Estimating and modeling space-time correlation structures显示文摘 | De Cesare L Myers D E Posa D | 2001 | Statistics &Probability Letters2001，51，1： | 1 |
| 18 | The toxicology of mercury-current exposures and clinical manifestations 显示文摘 | Clarkson T W Magos L Myers G J | 2003 | N Engl J Med2003，349，： | 1 |
| 19 | Market reac- tions to the disclosure of internal control weaknesses and to the characteristics of those weaknesses under Section 302 of the Sarbanes Oxley Act of 2002显示文摘 | Hammersley J S Myers L A Shakespeare C | 2008 | Review of Ac- counting Studies2008，13，1： | 1 |
| 20 | Market reactions to the disclosure of internal control weaknesses and to the characteristics of those weaknesses under section 302 of the Sarbanes Oxley Act of 2002显示文摘 | HAMMERSLEY J S MYERS L A SHAKESPEARE C | 2008 | Review of Accounting Studies2008，，13： | 1 |
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