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| 1 | Plasma betatrophin levels in patients with liver cirrhosis显示文摘AIM: To investigate the plasma levels of betatrophin in patients with cirrhosis.METHODS: Forty patients diagnosed at the clinic with liver cirrhosis according to biological, ultrasonographic,or histological criteria were included.The severity of cirrhosis was classified according to Pugh's modification of Child's classification and MELD score. Insulin resistance(IR) was assessed by the Homeostasis Model Assessment. A total of 20 patients showed a MELD score higher than 14. The control group consisted in 15 sex-and aged-matched subjects.Fasting blood samples were obtained for subsequent analysis. Serum insulin was determined by Liaison automated immune chemiluminiscence assay(DiaSorin S.p.A.) using a sandwich assay. The sensitivity of the assay was 0.2 μU/mL. The intra and interassay variation coefficients were < 4% and < 10%,respectively. The normal values were between 2 and17 μU/mL. Human active betatrophin was analyzed by specific quantitative sandwich ELISA(Aviscera Bioscience). The sensitivity of the assay was 0.4 ng/mL, and the intra and interassay reproducibility were< 6% and < 10%, respectively.RESULTS: Plasma betatrophin levels were significantly increased in patients with cirrhosis compared with those in healthy subjects(P = 0.0001). Betatrophin levels were also associated with disease severity, being higher in Child-Pugh C patients compared to Child-Pugh B(P< 0.0005) and in patients who displayed a MELD score higher than 14 points compared to patients with lower punctuation(P = 0.01). In addition, we found a positive correlation between plasma betatrophin levels and the severity of cirrhosis according to Child-Pugh classification(r = 0.53; P < 0.01) or MELD score(r = 0.45; P <0.01). In the overall cohort, a moderate correlation between serum betatrophin and plasmatic bilirrubin(r= 0.39; P < 0.01) has been observed, as well as an inverse correlation between betatrophin and albumin(r =-0.41; P < 0.01) or prothrombin time(r =-0.44;P <0.01). Moreover, insulin resistance was observed in82.5% of the cirrhotic patients. In this group of patients,betatrophin levels were significantly higher than those in the group of patients without IR(P < 0.05).CONCLUSION: Plasma betatrophin is increased in patients with cirrhosis. This increase is related to the severity of cirrhosis, as well as with the emergence of insulin resistance. | Maria Teresa Arias-Loste Maria Teresa García-Unzueta Susana Llerena Paula Iruzubieta Angela Puente Joaquín Cabezas Carmen Alonso Antonio Cuadrado José Antonio Amado Javier Crespo Emilio Fábrega | 2015 | World Journal of Gastroenterology2015，21，37： | 9 |
| 2 | Impact of an acute hemodynamic response-guided protocol for primary prophylaxis of variceal bleeding显示文摘AIM To evaluate the long-term outcome of an acute hemodynamic response-guided protocol in which acute responders to intravenous propranolol received traditional nonselective beta-blockers(NSBBs) and acute nonresponders received carvedilol.METHODS Retrospective review of a protocol for primary prophylaxis of variceal bleeding guided by the acute hemodynamic response to intravenous propranolol. Fifty-two acute responders treated with traditional NSBB(i.e. propranolol or nadolol) were compared with 24 acute nonresponders receiving carvedilol. A second hemodynamic study was performed in 27 and 13 patients, respectively. The primary endpoint was development of first or further decompensation. Secondary endpoints included death from any cause, association between acute and chronic hemodynamic response, and baseline clinical and laboratory variables related to the acute hemodynamic response.RESULTS Acute responders and acute nonresponders presented similar 1, 2, and 3-year probabilities of first decompensation(NSBB: 0%, 13.7%, 26.1% vs carvedilol: 0%, 20%, 20%, P = 0.968) or further decompensation(21.2%, 26.1%, 40.9% vs 21.2%, 50.0%, 50.0%, P = 0.525). A previous episode of hepatic encephalopathy was the only independent predictor of decompensation [hazard ratio(95% confidence interval): 8.03(2.76-23.37)]. Mortality rates were similar in acute responders and acute nonresponders with compensated(P = 0.428) or decompensated cirrhosis(P = 0.429). No clinical, laboratory, endoscopic or hemodynamic parameter predicted the acute hemodynamic response. In patients receiving traditional NSBB, the acute and chronic changes of hepatic venous pressure gradient were correlated(r = 0.59, P = 0.001). Up to 69.2% of acute nonresponders gained chronic response with carvedilol.CONCLUSION Early identification and treatment with carvedilol of acute nonresponders to intravenous propranolol improves the clinical outcome of this high-risk group of patients, probably due to its greater effects for reducing portal pressure. | José Ignacio Fortea ángela Puente Patricia Ruiz Iranzu Ezcurra Javier Vaquero Antonio Cuadrado María Teresa Arias-Loste Joaquín Cabezas Susana Llerena Paula Iruzubieta Carlos Rodríguez-Lope Patricia Huelin Fernando Casafont Emilio Fábrega Javier Crespo | 2018 | World Journal of Clinical Cases2018，6，13： | 6 |
| 3 | Review on thermal energy storage with phase change: materials, heat transfer analysis and applications显示文摘 | Belén Zalba José M a Mar??n Luisa F. Cabeza Harald Mehling | 2002 | Applied Thermal Engineering2002，，3： | 3 |
| 4 | State of the art on high temperature thermal energy storage for power generation. Part 1—Concepts, materials and modellization显示文摘 | Antoni Gil Marc Medrano Ingrid Martorell Ana Lázaro Pablo Dolado Belén Zalba Luisa F. Cabeza | 2009 | Renewable and Sustainable Energy Reviews2009，，1： | 2 |
| 5 | Computerized physician order entry‐based system to prevent HBV reactivation in patients treated with biologic agents: The PRESCRIB project显示文摘 | Blanca Sampedro Cándido Hernández‐López José Ramón Ferrandiz Aitziber Illaro Emilio Fábrega Antonio Cuadrado Paula Iruzubieta Susana Menéndez Joaquín Cabezas Javier Crespo | 2014 | Hepatology2014，，1： | 2 |
| 6 | State of the art on high temperature thermal energy storage for power generation. Part 1—Concepts, materials and modellization显示文摘 | Antoni Gil Marc Medrano Ingrid Martorell Ana Lázaro Pablo Dolado Belén Zalba Luisa F. Cabeza | 2009 | Renewable and Sustainable Energy Reviews2009，，1： | 2 |
| 7 | Prevalence of aspirin resistance in patients with type 2 diabetes显示文摘 | Fateh-Moghadarn S Plockinger U Cabeza N | 2005 | Acta Diabetol2005，42，2： | 1 |
| 8 | Surface expression of collagen receptor Fc receptor-γ/glycoprotein VI is enhanced on platelets in type 2 diabetes and mediates release of CD40 ligand and activation of endothelial cells显示文摘 | Cabeza N Li Z Schulz C | 2004 | Diabetes2004，53，8： | 1 |
| 9 | Surface expression of collagen receptor Fc receptor/Glycoprotein VI is enhanced on platelets in type 2 diabetes and mediates release of CD 40 ligand and activation of endothelial cells 显示文摘 | Cabeza N Zhi L Schulz C | 2004 | Diabetes2004，53，8： | 1 |
| 10 | Electronic nose : auseful tool for monitoring environmental contamination 显示文摘 | Baby R E Cabezas M Walsoe de Reca E N | 2000 | Sensors and Actuators B: Chemical2000，69，3： | 1 |
| 11 | Use of tryptec enzyme preparations in treatment of chrome shavings 显示文摘 | Maryann M Taylor Luisa F Cabeza William N Mariner | 2000 | JALCA2000，95，： | 1 |
| 12 | The intestinal anti - inflammatory effect of dersalazine sodium is relat- ed to a downregulation in IL - 17 production in experimental mod- els of rodent colitis显示文摘 | Camuesco D Rodriguez - Cabezas M Garrido - Mesa N | 2011 | Br J Pharmacol2011，7，： | 1 |
| 13 | Review on thermal energy storage with phase change:Materials,heat transfer analysis and applications显示文摘 | Zalba B Mar?n J M Cabeza L F | 2003 | Applied Thermal Engineering2003，23，： | 1 |
| 14 | Surface expression d collagen receptor Fc receptor-gamma/glycoprotein Ⅵ is enhanced on platelets in type 2 diabetes and mediates relessc of CD40 ligand and activation of endothelial cells显示文摘 | Cabeza N Li Z Schulz C | 2004 | Diabetes2004，53，8： | 1 |
| 15 | Electronic nose:a useful tool for monitoring environmental contamination显示文摘 | Baby R E Cabezas M Walse de Reca E N | 2000 | Sensors and Actuators B:Chemical2000，69，3： | 1 |
| 16 | Use of Micro-Encapsulated PCM in Concrete Walls for Energy Savings 显示文摘 | Cabeza L F Castello'n C Nogue's M | 2007 | Energy Buildings2007，39，： | 1 |
| 17 | The effects of divided attention on encoding-and retrieval-related brain activity: a PET study of younger and older adults显示文摘 | Anderson N D Iidaka T Cabeza R | 2000 | J Cogn Neurosci2000，12，5： | 1 |
| 18 | Use of tryptee enzyme preparations in treatment of chrome shavings 显示文摘 | MARYANN M TAYLOR LUISA F CABEZA WILLIAM N MARM- ER | 2000 | JALCA2000，95，5： | 1 |
| 19 | State of the art on high temperature thermal energy storage for power generation. Part 1—Concepts, materials and modellization显示文摘 | Antoni Gil Marc Medrano Ingrid Martorell Ana Lázaro Pablo Dolado Belén Zalba Luisa F. Cabeza | 2009 | Renewable and Sustainable Energy Reviews2009，，1： | 1 |
| 20 | Computer-assisted method to measure the adhesive properties of hydrolysis products from collagen显示文摘 | Taylor M M Cabeza L F Marmer W N | 1997 | JALCA1997，92，： | 1 |
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