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| 1 | 在有煽动性、非煽动性的腹的疼痛显型的孩子的 interleukin-6 和桅杆房间的反的关系显示文摘 AIM: To investigate interleukin-6 (IL-6), mast cells, enterochromaffin cells, 5-hydroxytryptamine, and substance P in the gastrointestinal mucosa of children with abdominal pain. METHODS: Formalin-fixed paraffin-embedded gas-trointestinal biopsy blocks from patients (n = 48) with non-inflammatory bowel disease (irritable bowel syndrome and functional abdominal pain) and inflammatory bowel disease were sectioned and stained for IL-6, mast cells, enterochromaffin cells, 5-hydroxytryptamine, and substance P. All children had chronic abdominal pain as part of their presenting symptoms. Biopsy phenotype was confirmed by a pathologist, blinded to patient information. Descriptive statistics, chi-square, and independent sample t tests were used to compare differences between the inflammatory and non-inflammatory groups. RESULTS: The cohort (n = 48), mean age 11.9 years (SD = 2.9), 54.2% females, 90% Caucasian, was comprised of a non-inflammatory (n = 26) and an inflammatory (n = 22) phenotype. There was a significant negative correlation between substance P expression and mast cell count (P = 0.05, r = -0.373). Substance P was found to be expressed more often in female patient biopsies and more intensely in the upper gastrointestinal mucosa as compared to the lower mucosa. There were significantly increased gastrointestinal mucosal immunoreactivity to IL-6 (P = 0.004) in the inflammatory phenotype compared to non-inflammatory. Additionally, we found significantly increased mast cells (P = 0.049) in the mucosa of the non-inflammatory phenotype compared to the inflammatory group. This difference was particularly noted in the lower colon biopsies. CONCLUSION: The findings of this study yield preliminary evidence in identifying biomarkers of undiagnosed abdominal pain in children and may suggest candidate genes for future evaluation. | Wendy A Henderson Ravi Shankar Tara J Taylor Arseima Y Del Valle-Pinero David E Kleiner Kevin H Kim Nader N Youssef | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，6： | 2 |
| 2 | Comparison of methods to detect biosurfactant production by diverse microorganisms 显示文摘 | Youssef N H Duncan K E Nagle D P | 2004 | Journal of Microbiological Methods2004，56，3： | 1 |
| 3 | Antioxidant defense system in leaves of Indian mustard (Brassica juncea) and rape (Brassvica napus) under cadmium stress显示文摘 | Nouairi I Ben Ammar W Ben Youssef N | 2009 | Acta Physiologiae Plantarum2009，31，2： | 1 |
| 4 | Simulated polarimetric signatures of primitive geometrical shapes显示文摘 | Cameron W L Youssef N N Leung L K | 1996 | IEEE Trans Geosci Remote Sens1996，34，3： | 1 |
| 5 | Primary hyperoxaluria type 1 in Tunisian children显示文摘 | Gargah T Khelil N Youssef G | | 0，，2： | 1 |
| 6 | Incidence and Diversity of Nestyphodium Fungal Endophytes in Tall Fescue from Morocco, Tunisia, and Sardinia显示文摘 | Clement S L Elberson L R Youssef N N | 2001 | Crop Science2001，41，： | 1 |
| 7 | Influence of r-irradiation on the bioconversion of rice straw by Tricho-derma vi ride显示文摘 | Youssef Bothaina M Aziz N H | 1999 | Into Single Cell Protein1999，97，386： | 1 |
| 8 | Stress- strain model for concrete confined by FRP composites 显示文摘 | Youssef M N Feng M Q Mosallam A S | 2007 | Composites: Part B2007，38，56： | 1 |
| 9 | RCS of Complex Target 显示文摘 | Youssef N N | 1989 | Proceeding of the IEEE1989，77，5： | 1 |
| 10 | Simulated Polarimetric Signatures of Primitive Geometrical Shapes 显示文摘 | Cameron W L Youssef N N Leung L K | 1996 | IEEE Transactions on Geoscience and Remote Sensing1996，34，3： | 1 |
| 11 | Radar cross section of complex targets 显示文摘 | Youssef N N | 1989 | Proceedings of the IEEE1989，77，5： | 1 |
| 12 | Thermovapor compression desalters:energy and availability-analysis of single-and multi-effect sys tems显示文摘 | AI-NAJERN N M DARWISH M A YOUSSEF F A | | 0，，03： | 1 |
| 13 | Haemodynamic alterations induced by toxic level of sodium taurocholate显示文摘 | Youssef S A Ramadan A Afifi N A | 1991 | Dtsch Tierarztl Wochenschr1991，98，2： | 1 |
| 14 | Synthesis and coordinating properties of new chromone thiosemicarbazones towards some transition metal i- ons显示文摘 | Youssef N S Hegab K H Eid A E | 2003 | Synthesis and reactivity in inorganic and metal -organic chemistry2003，33，9： | 1 |
| 15 | Phase transitions in some epidemic models defined on small-world networks显示文摘 | Agiza H N Elgazzar A S Youssef S A | 2003 | Int J Mod Phys C2003，14，6： | 1 |
| 16 | Radar cross section of complex target显示文摘 | Youssef N N | 1989 | Proceeding of the IEEE1989，77，5： | 1 |
| 17 | Replicative Senescence in Normal Liver, Chronic Hepatitis C, and Hepatocellular Carcinomas显示文摘 | Paradis V Youssef N Dargere D | 2001 | Hum Pathol2001，32，3： | 1 |
| 18 | In sita detection of telomerase enzymatic activity in human hepatocallular carcinogenesis显示文摘 | Youssef N Parndis V Ferlivot S | 2001 | I Pathol2001，194，4： | 1 |
| 19 | Radar cross section of complex targets显示文摘 | Youssef N N | 1989 | Proceeding of The IEEE1989，77，5： | 1 |
| 20 | Viscous dampers at multiple levels for the historic preservation of Los Angeles City Hall显示文摘 | N Youssef | 2001 | The Structural Design of Tall Building2001，10，： | 1 |
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