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| 1 | 在有煽动性、非煽动性的腹的疼痛显型的孩子的 interleukin-6 和桅杆房间的反的关系显示文摘 AIM: To investigate interleukin-6 (IL-6), mast cells, enterochromaffin cells, 5-hydroxytryptamine, and substance P in the gastrointestinal mucosa of children with abdominal pain. METHODS: Formalin-fixed paraffin-embedded gas-trointestinal biopsy blocks from patients (n = 48) with non-inflammatory bowel disease (irritable bowel syndrome and functional abdominal pain) and inflammatory bowel disease were sectioned and stained for IL-6, mast cells, enterochromaffin cells, 5-hydroxytryptamine, and substance P. All children had chronic abdominal pain as part of their presenting symptoms. Biopsy phenotype was confirmed by a pathologist, blinded to patient information. Descriptive statistics, chi-square, and independent sample t tests were used to compare differences between the inflammatory and non-inflammatory groups. RESULTS: The cohort (n = 48), mean age 11.9 years (SD = 2.9), 54.2% females, 90% Caucasian, was comprised of a non-inflammatory (n = 26) and an inflammatory (n = 22) phenotype. There was a significant negative correlation between substance P expression and mast cell count (P = 0.05, r = -0.373). Substance P was found to be expressed more often in female patient biopsies and more intensely in the upper gastrointestinal mucosa as compared to the lower mucosa. There were significantly increased gastrointestinal mucosal immunoreactivity to IL-6 (P = 0.004) in the inflammatory phenotype compared to non-inflammatory. Additionally, we found significantly increased mast cells (P = 0.049) in the mucosa of the non-inflammatory phenotype compared to the inflammatory group. This difference was particularly noted in the lower colon biopsies. CONCLUSION: The findings of this study yield preliminary evidence in identifying biomarkers of undiagnosed abdominal pain in children and may suggest candidate genes for future evaluation. | Wendy A Henderson Ravi Shankar Tara J Taylor Arseima Y Del Valle-Pinero David E Kleiner Kevin H Kim Nader N Youssef | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，6： | 2 |
| 2 | Suspension Cable Design of the New San Francisco-Oakland Bay Bridge显示文摘 | SUN J MANZANAREZ R NADER M | 2014 | Journal of Bridge Engineering2014，9，1： | 1 |
| 3 | Synthesis and characterization of silicone-modified vinyl acetate-acrylic emulsion copolymers显示文摘 | Hamid J N Shadpour M Nader M | 2006 | Progress in Organic Coatings2006，55，4： | 1 |
| 4 | Shell's flue gas desulfurization process显示文摘 | Dautaenberg F W Nader J E | 1971 | Chem Eng Prog1971，67，8： | 1 |
| 5 | Suspension cable design of the New San Francisco-Oakland Bay Bridge显示文摘 | Sun J Manzanarez R Nader M | 2004 | Journal of Bridge Engineering ASCE2004，9，1： | 1 |
| 6 | Design of looping anchorage system for new San Francisco-Oakland Bay Bridge main suspension span显示文摘 | Sun J Manzanarez R Nader M | 2002 | Journal of Bridge Engineering ASCE2002，7，6： | 1 |
| 7 | Blood Pressure,C- Reactive Protein, and Risk of Future Cardiovascular Events显示文摘 | Blake Gavin J Rifai Nader Buring Julie E | 2003 | Circulation2003，108，24： | 1 |
| 8 | A review of atomic force microscopy imaging systems: application to molecular metrology and bio- logical sciences显示文摘 | NADER J KARTHIK L | 2004 | Mechatronics2004，14，8： | 1 |
| 9 | Transversus abdominis plane block to ameliorate postoperative pain outcomes after laparoscopic surgery: a meta-analysis of randomized controlled trials显示文摘 | De-Oliveira G S Jr Castro-Alves L J Nader A | 2014 | Anesth Analg2014，118，2： | 1 |
| 10 | A comparative study and analysis of semi-active vibration-control systems显示文摘 | Nader J | 2002 | Journal of Vibration and Acoustics2002，124，4： | 1 |
| 11 | Design of looping cable anchorage system for new San Francisco-Oakland Bay Bridge main suspension span 显示文摘 | Sun J Manzanarez R Nader M | 2002 | Journal of Bridge Engineering ASCE2002，7，6： | 1 |
| 12 | Nonlinear analysis of the Vincentt Thomas Bridge for seismic retroit显示文摘 | INGHAM T J RODRIGUEZ S NADER M | 1997 | Computers & Structures1997，64，56： | 1 |
| 13 | A comparative study and analysis of semi-active vibration-con- trol systems 显示文摘 | Nader J | 2002 | Journal of Vibration and Acoustics2002，124，4： | 1 |
| 14 | Inflammation and Progressive Nephropathy in Type 1 Diabetes in the Diabetes Control and Complications Trial显示文摘 | Lin Julie Glynn Robert J Rifai Nader Manson JoAnn E Ridker Paul M Nathan David M Schaumberg Debra A | 2008 | Diabetes Care2008，，12： | 1 |
| 15 | Method for measuring microbial growth in rument content显示文摘 | Walker D J Nader C J | 1968 | Appl Microbiol1968，16，： | 1 |
| 16 | Different lateral amygdala outputs mediate reactions and actions elicited by a fear-arousing stimulus 显示文摘 | Amorapanth P LeDoux J E Nader K | 2000 | Nat Neurosci2000，3，1： | 1 |
| 17 | In- fluence of the α/β-SiC phase transformation on micro- structural development and mechanical properties of liquid phase sintered silicon carbide显示文摘 | NADER M ALDINGER F HOFFMANN M J | 1999 | J Mater Sci1999，34，6： | 1 |
| 18 | Optimum active vehicle suspensions with actuator time delay显示文摘 | Nader J Ebrahim E | 2001 | Transactions of the ASME2001，123，： | 1 |
| 19 | Cellular and systems reconsolidation in the hippocampus显示文摘 | Debiec J LeDoux JE Nader K | 2002 | Neuron2002，36，： | 1 |
| 20 | Nonlinear analysis of the Vincent Thomas Bridge for seismic retrofit显示文摘 | INGHAM T J RODRIGUEZ S NADER M | 1997 | Computer & Structure1997，64，5： | 1 |
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