|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | 在有煽动性、非煽动性的腹的疼痛显型的孩子的 interleukin-6 和桅杆房间的反的关系显示文摘 AIM: To investigate interleukin-6 (IL-6), mast cells, enterochromaffin cells, 5-hydroxytryptamine, and substance P in the gastrointestinal mucosa of children with abdominal pain. METHODS: Formalin-fixed paraffin-embedded gas-trointestinal biopsy blocks from patients (n = 48) with non-inflammatory bowel disease (irritable bowel syndrome and functional abdominal pain) and inflammatory bowel disease were sectioned and stained for IL-6, mast cells, enterochromaffin cells, 5-hydroxytryptamine, and substance P. All children had chronic abdominal pain as part of their presenting symptoms. Biopsy phenotype was confirmed by a pathologist, blinded to patient information. Descriptive statistics, chi-square, and independent sample t tests were used to compare differences between the inflammatory and non-inflammatory groups. RESULTS: The cohort (n = 48), mean age 11.9 years (SD = 2.9), 54.2% females, 90% Caucasian, was comprised of a non-inflammatory (n = 26) and an inflammatory (n = 22) phenotype. There was a significant negative correlation between substance P expression and mast cell count (P = 0.05, r = -0.373). Substance P was found to be expressed more often in female patient biopsies and more intensely in the upper gastrointestinal mucosa as compared to the lower mucosa. There were significantly increased gastrointestinal mucosal immunoreactivity to IL-6 (P = 0.004) in the inflammatory phenotype compared to non-inflammatory. Additionally, we found significantly increased mast cells (P = 0.049) in the mucosa of the non-inflammatory phenotype compared to the inflammatory group. This difference was particularly noted in the lower colon biopsies. CONCLUSION: The findings of this study yield preliminary evidence in identifying biomarkers of undiagnosed abdominal pain in children and may suggest candidate genes for future evaluation. | Wendy A Henderson Ravi Shankar Tara J Taylor Arseima Y Del Valle-Pinero David E Kleiner Kevin H Kim Nader N Youssef | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，6： | 2 |
| 2 | Dynamic stress concentrations for an axially loaded strut at discontinuities due to an elliptical hole or double circular notches显示文摘 | WILLIAM A NADER Z WALTER N | 2004 | International Journal of Impact Engineering2004，30，3： | 1 |
| 3 | Circadian rhythm transcription factor CLOCK regulates the transcriptional activity of the glucocorticoid receptor by acetylating its hinge region lysine cluster:potential physiological implications显示文摘 | Nader N Chrousos G P Kino T | 2009 | FASEB J2009，23，5： | 1 |
| 4 | Preparation of polystyrene/poly(vinyl acetate) nanocomposites with a core-shell structure via emulsifier-free emulsion polymerization显示文摘 | Morteza S D Naser S S Nader N | 2006 | Journal of Applied Science2006，100，： | 1 |
| 5 | Superovlatory Response in Bos Indi- cus Breeds,Breeds,Borders or Lack of Knowledge 显示文摘 | Armaser R D Aparicio N Nader C | 2001 | Archives of Animal Breeding2001，44，： | 1 |
| 6 | Interactions of the circadian CLOCK system and the HPA axis显示文摘 | Nader N Chrousos G P Kino T | 2010 | Trends Endocrinol Metab2010，21，5： | 1 |
| 7 | Preparation of organic-inorganic nanocomposites with core-shell structure by inorganic powders显示文摘 | Nader N Naser S Baharak K N | 2006 | Appl Polym Sci2006，99，： | 1 |
| 8 | Mitolane has an estrogenic effect on sex hornnme-binding globulin and cnrtieosternid-binding globulin in humans 显示文摘 | Nader N Raverot ( Emptoz-Bonnelon A el al | 2006 | J Clia Endocrinnl Metab2006，91，： | 1 |
| 9 | Sex hormone-binding globulin gene expression in the liver:drugs and the metabolic syndrome显示文摘 | Pugeat M Nader N Hogeveen K | | 0，，01： | 1 |
| 10 | Tuber hydroforming of automotive side members with extruded aluminium profiles显示文摘 | Nader A Tomas N Gunnar L | 2003 | Journal of Materials Processing Technology2003，142，1： | 1 |
| 11 | Synthesis and characterization of silicone-modified vinyl acetate-acrylic emulsion copolymers显示文摘 | Hamid J N Shadpour M Nader M | 2006 | Progress in Organic Coatings2006，55，4： | 1 |
| 12 | Pharyngocutaneous fistula after laryngectomy:incidence,predisposing factors,and outcome显示文摘 | Nader S Soheila N Maryam K | 2008 | Arch Iranian Med2008，11，3： | 1 |
| 13 | ClinRep Combined Kit for the Determination of Vitamins B1, B2 and B6 显示文摘 | Dirsch N Nader H Blum W | 1998 | Manage Krankenhaus1998，，9： | 1 |
| 14 | The role of coinhibitory signaling path- ways in transplantation and tolerance 显示文摘 | Martina MM Nader N | 2012 | Front Immunol2012，3，： | 1 |
| 15 | Shaking table tests of rigid and semi-rigid flexible steel frames 显示文摘 | Nader M N Abolhassan A-Asl | 1996 | Journal of Structural Engineering1996，122，6： | 1 |
| 16 | Shaking table test or rigid, semirigid,and flexible steel frames 显示文摘 | NADER M N ASTANEH-ASL A | 1996 | Journal of Structural Engineering ASCE1996，122，6： | 1 |
| 17 | REVIEW: Fast- Tracking Cardiac Surgery 显示文摘 | Pande R U Nader N D Donias H W | 2003 | Heart Surg Forum2003，6，4： | 1 |
| 18 | Review article:The role of statins in reducing perioperative cardiac risk:physiologic and clinical perspectives显示文摘 | Nader N | 2006 | CAN J ANESTH2006，53，11： | 1 |
| 19 | The role of alveolar macrophages in the pathogenesis of aspiration pneumonitis 显示文摘 | Nader N D McQuiller P S | 2007 | Immunol Invest2007，36，4： | 1 |
| 20 | Obstructive malformation of the verumontanum 显示文摘 | Ayzouki I Nader N Ludwig L | 1999 | Prog Urol1999，9，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员