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| 1 | 在有煽动性、非煽动性的腹的疼痛显型的孩子的 interleukin-6 和桅杆房间的反的关系显示文摘 AIM: To investigate interleukin-6 (IL-6), mast cells, enterochromaffin cells, 5-hydroxytryptamine, and substance P in the gastrointestinal mucosa of children with abdominal pain. METHODS: Formalin-fixed paraffin-embedded gas-trointestinal biopsy blocks from patients (n = 48) with non-inflammatory bowel disease (irritable bowel syndrome and functional abdominal pain) and inflammatory bowel disease were sectioned and stained for IL-6, mast cells, enterochromaffin cells, 5-hydroxytryptamine, and substance P. All children had chronic abdominal pain as part of their presenting symptoms. Biopsy phenotype was confirmed by a pathologist, blinded to patient information. Descriptive statistics, chi-square, and independent sample t tests were used to compare differences between the inflammatory and non-inflammatory groups. RESULTS: The cohort (n = 48), mean age 11.9 years (SD = 2.9), 54.2% females, 90% Caucasian, was comprised of a non-inflammatory (n = 26) and an inflammatory (n = 22) phenotype. There was a significant negative correlation between substance P expression and mast cell count (P = 0.05, r = -0.373). Substance P was found to be expressed more often in female patient biopsies and more intensely in the upper gastrointestinal mucosa as compared to the lower mucosa. There were significantly increased gastrointestinal mucosal immunoreactivity to IL-6 (P = 0.004) in the inflammatory phenotype compared to non-inflammatory. Additionally, we found significantly increased mast cells (P = 0.049) in the mucosa of the non-inflammatory phenotype compared to the inflammatory group. This difference was particularly noted in the lower colon biopsies. CONCLUSION: The findings of this study yield preliminary evidence in identifying biomarkers of undiagnosed abdominal pain in children and may suggest candidate genes for future evaluation. | Wendy A Henderson Ravi Shankar Tara J Taylor Arseima Y Del Valle-Pinero David E Kleiner Kevin H Kim Nader N Youssef | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，6： | 2 |
| 2 | Effects of maceration of rice straw on voluntary intake and performance of growing beef cattle fed rice straw-based rations 显示文摘 | Nader G A Robinson P H | 2008 | Animal Feed Science and Technology2008，146，12： | 1 |
| 3 | Weed Control and Sensitivity of Oats(Avena sativa) with Various Doses of Saflufenacil显示文摘 | NADER S CHRISTY S PETER H S | 2012 | Crop Protection2012，，31： | 1 |
| 4 | Detection and analysis of two serotypes of ammonia-oxidizing bacteria in sewage plants by flow cytometry显示文摘 | VOLSCH A NADER W F GEISS H K | 1990 | Applied and Environment Microbiology1990，56，8： | 1 |
| 5 | ClinRep Combined Kit for the Determination of Vitamins B1, B2 and B6 显示文摘 | Dirsch N Nader H Blum W | 1998 | Manage Krankenhaus1998，，9： | 1 |
| 6 | Petroleum prospects of Lebanon:some remarks from sedimentological and diagenetic studies of Jurassic carbonates显示文摘 | Fadi H Nader Rudy Swennen | 2004 | Marine and Petroleum Geology2004，21，： | 1 |
| 7 | A longitudinal,integrated,clinical,histological and mRNA profiling study of resistance exercise in myositis显示文摘 | Nader GA Dastmalchi M Alexanderson H | | 0，，11： | 1 |
| 8 | The permeability of a uniformly vuggy porous medium 显示文摘 | Neale G H Nader W K | 1973 | SPE Journal1973，13，2： | 1 |
| 9 | Determination of the Best Coverage Area for Receiver Stations of LEO Remote Sensing Satellites显示文摘 | Leila M Nader M Adel H | 2008 | ICTTA2008，，： | 1 |
| 10 | REVIEW: Fast- Tracking Cardiac Surgery 显示文摘 | Pande R U Nader N D Donias H W | 2003 | Heart Surg Forum2003，6，4： | 1 |
| 11 | Quantification and prediction of the 3D pore network evolution in carbonate reservoir rocks显示文摘 | Boever E D Varloteaux C Nader F H | 2012 | Oil & Gas Science and Technology2012，67，1： | 1 |
| 12 | Thermal fatigue of cast irons for automotive application 显示文摘 | Dhouha M Nader H Alain K | 2011 | Materials and Design2011，3，32： | 1 |
| 13 | Effect of different glycosaminoglycans in a guinea-pig carotid artery thrombosis model显示文摘 | LUCI M MATTEIFHA NADER H B | 1994 | Thromb Res1994，75，6： | 1 |
| 14 | A longitudinal integrated clinical histological and mRNA profiling study of resistance exercise in myositis显示文摘 | Nader GA Dastmalchi M Alexanderson H | 2010 | Molecular medicine2010，16，1112： | 1 |
| 15 | Dry Bean Response to Preemergence-applied KIH-485显示文摘 | PETER H S CHRISTY S NADER S | 2007 | Weed Technology2007，21，1： | 1 |
| 16 | Effect of betulinic acid on neutrophil recruitment and inflammatory mediator expression in lipopolysac- charide-induced lung inflammation in rats 显示文摘 | Nader M A Baraka H N | 2012 | Eur J Pharm Sci2012，46，12： | 1 |
| 17 | The permeability of a uniformly vuggy porous medium 显示文摘 | Neale G H Nader W K | 1973 | Society of Petroleum Engineers Journal1973，13，2： | 1 |
| 18 | On the PDF of the sum of random vectors 显示文摘 | SABDI A HASH NADER E S | 2000 | IEEE Transactions on Communications2000，48，1： | 1 |
| 19 | Moderate- to-vigorous physical activity from age 9 to 15 years显示文摘 | NADER P R BRADLEY R H HOUTS R M | 2008 | JAMA2008，，3： | 1 |
| 20 | Bandwidth, cross-polarization, and feed-point characteristics of matched Hubert antennas显示文摘 | Zhu J H Ahmad H Nader E | 2003 | IEEE Antennas and Wireless Propagation Letters2003，2，： | 1 |
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