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| 1 | Strong significant correlation between MMP-9and systemic symptoms in patients with localized renal cell carcinoma显示文摘 | Kawata N Nagane Y Igarashi T | 2006 | Urology2006，68，3： | 1 |
| 2 | Development of Static and Simulation Programs for Voltage Stability Studies of Bulk Power System 显示文摘 | NAGAN T TANAKA K TAKENKA K | 1997 | IEEE Transactions on Power Systems1997，12，1： | 1 |
| 3 | Characterization of gmhsp26A, a stress gene encoding a divergent heat shock protein of soybean: heavy metal-induced inhibition of intron processing显示文摘 | Czanlecka E Nagan R T Key J L | 1988 | Mol Cell B iol1988，8，3： | 1 |
| 4 | Energy value and digestibility of dietary oil containing 1,3-DG显示文摘 | Taguchi H Nagan T Watanabe H | 2001 | Lipids2001，6，4： | 1 |
| 5 | Strong significant correlation between MMP-9 and systemic symptoms in patients with localized renal cell carcinoma显示文摘 | Kawata N Nagane Y Igarashi T | 2006 | Urology2006，68，3： | 1 |
| 6 | Strong significant correlation between MMP-9 and systemic symptoms in patients with localized renal cell carcinoma显示文摘 | Kawata N Nagane Y Igarashi T | 2006 | Urology2006，68，3： | 1 |
| 7 | Strong significant correlation between MMP-9 and systemic symptoms in patients with localized renal cell carcinoma 显示文摘 | Kawata N Nagane Y Igarashi T | 2006 | Urology2006，68，3： | 1 |
| 8 | Interaction of Cu( Ⅱ )-Arg- 31y-His Xaa metallopeptides with DNA: Effect of C-terminal residues,Leu and Glu显示文摘 | Nagane R Koshigoe T Chikira M | 2003 | Journal of Inorganic Biochemistry2003，93，： | 1 |
| 9 | Strong sig- nificant correlation between MMP-9 and systemic symptoms in patients with localized renal cell carcinoma 显示文摘 | KAWATA N NAGANE Y LGARASHI T | 2006 | Urology2006，68，： | 1 |
| 10 | Catalytic performance of rhodium supported on ceria-zirconia mixed oxides for reduction of NO by propene显示文摘 | HANEDA M SHINODA K NAGANE A HOUSHITO O TAKAGI H NAKAHARA Y HIROE K FUJITANI T HAMADA H | | 0，，02： | 1 |
| 11 | Strong signifi- cant correlation between MMP - 9 and systemic symptoms in pa- tients with localized renal cell carcinoma 显示文摘 | KAWATA N NAGANE Y IGARASHI T | 2006 | Urology2006，68，3： | 1 |
| 12 | Strong significant correlation between MMP-9 and systemic symptoms in patients with localized renal cell carcinoma显示文摘 | Kawata N Nagane Y Igarashi T | 2006 | Urology2006，68，3： | 1 |
| 13 | Randomized trial of chemoradiotherapy and adjuvant chemotherapy with nimustine (ACNU) versus nimustine plus procarbazine for newly diagnosed anaplastic astrocytoma and glioblastoma (JCOG0305)显示文摘Objectives: Glioblastoma(GBM) is one of the worst cancers in terms of prognosis.Standard therapy consists of resection with concomitant chemoradiotherapy.Resistance to nimustine hydrochloride(ACNU),an alkylating agent,has been linked to methylguanine DNA methyltransferase(MGMT).Daily administration of procarbazine(PCZ) has been reported to decrease MGMT activity.This study investigated the efficacy of ACNU + PCZ compared to ACNU alone for GBM and anaplastic astrocytoma(AA).Methods: Patients(20-69 years) who had newly diagnosed AA and GBM were randomly assigned to receive radiotherapy with ACNU alone or with ACNU + PCZ.The primary endpoint was overall survival(OS).This was designed as a phase Ⅱ/Ⅲ trial with a total sample size of 310 patients and was registered as UMIN-CTR C000000108.Results: After 111 patients from 19 centers in Japan were enrolled,this study was terminated early because temozolomide was newly approved in Japan.The median OS and median progression-free survival(PFS) with ACNU alone(n = 55) or ACNU + PCZ(n = 56) in the intention-to-treat population were 27.4 and 22.4 months(P = 0.75),and 8.6 and 6.9 months,respectively.The median OS and median PFS of the GBM subgroup treated with ACNU alone(n = 40) or ACNU + PCZ(n = 41) were 19.0 and 19.5 months,and 6.2 and 6.3 months,respectively.Grade 3/4 hematologic adverse events occurred in more than 40% of patients in both arms,and 27% of patients discontinued treatment because of adverse events.Conclusions: The addition of PCZ to ACNU was not beneficial,in comparison with ACNU alone,for patients with newly diagnosed AA and GBM. | Shibui S Narita Y Mizusawa J Beppu T Ogasawara K Sawamura Y Kobayashi H Nishikawa R Mishima K Muragaki Y Maruyama T Kuratsu J Nakamura H Kochi M Minamida Y Yamaki T Kumabe T Tominaga T Kayama T Sakurada K Nagane M Kobayashi K Nakamura H Ito T Yazaki T Sasaki H Tanaka K Takahashi H Asai A Todo T Wakabayashi T Takahashi J Takano S Fujimaki T Sumi M Miyakita Y Nakazato Y Sato A Fukuda H Nomura K | 2013 | 中国神经肿瘤杂志2013，11，1： | 0 |
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