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56篇 您的检索式：作者名="NAKADA TA"

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	题名	作者	年代	出处	被引量
1	脑缺血后N-myc下游调控基因2保护血脑屏障完整性显示文摘脑缺血后血脑屏障(BBB)的破坏与外周细胞向脑内浸润、病孔损形成与进展、以及临床病程恶化密切相关。目前BBB完整性的调控机制,尤其是在永久性缺血后的调控机制尚未明确。本研究使用小鼠永久性脑缺血模型进行相关研究,结果显示,星形胶质细胞N-myc下游调控基因2(NDRG2)可能是缺血性脑卒中后BBB通透性的调控分子,该分子与分化和应激相关。免疫组化显示,在永久性大脑中动脉闭塞(MCAO)后,NDRG2在星形胶质细胞中的表达显著增加。敲除NDRG2基因,脑梗死体积增加,免疫细胞在缺血同侧大脑半球积聚增加。MCAO后,NDRG2基因敲除小鼠缺血侧皮质的缺血灶内及灶周血管周围区域内的血清蛋白(包括纤维蛋白原和免疫球蛋白)的外渗增强此之,MCAO后NDRG2基因敲除小鼠体内基质金属蛋白酶(MMPs)的表达也显著增加。在细胞培养中,NDRG2-/-星形胶质细胞中MMP-3的表达和分泌增加,这种增加可被腺病毒介导的NDRG2再表达所逆转。综上所述,脑缺血后,星形胶质细胞内的NDRG2可能通过调节MMP的表达,而在BBB通透性的调节和免疫细胞浸润中起到重要作用。	Takarada-Iemata M Yoshikawa A Ta HM Okitani N Nishiuchi T Aida Y Kamide T Hattori T Ishii H Tamatani T Le TM Roboon J Kitao Y Matsuyama T Nakada M Hori O 聂昊	2018	神经损伤与功能重建2018，13，4：	4
2	Fluid resuscitation in septic shock : a positive fluid balance and elevated central venous pressure are associated with increased mortality 显示文摘	Boyd JH Forbes J Nakada TA	2011	Crit Care Med2011，39，2：	1
3	Norrnal-range blood lactate concentration in septic shock is prognostic and pre- dictive显示文摘	Wacharasint P Nakada TA Boyd JH	2012	Shock2012，38，1：	1
4	Continuous hemodiafiltration with PMMA Hemofilter in the treatment of patients with septic shock显示文摘	Nakada TA Oda S Matsuda K:	2008	Mol Med2008，14，56：	1
5	Fluid resuscitation in septic shock:a positive fluid balance and elevated central venous pressure are associated with in increased mortality显示文摘	Boyd JH Forbes J Nakada TA	2011	Crit Care Med2011，39，3：	1
6	Normal - range blood lactate concentration in septic shock is prognostic and pre?dictive显示文摘	Wacharasint P Nakada TA Boyd lH	2012	Shock2012，38，1：	1
7	Influence of loll-like receptor4, CDI4, tumor necrosis factor, and interleukine-10 gene polymorphisms on clinical outcome in Japanese critically ill patients显示文摘	Nakada TA Hirasawa H Oda S	2005	J Surg Res2005，129，：	1
8	Influence of toll - like receptor 4, CD14, tumor necrosis factor, and interleukine - 10 gene polymorphisms on clinical outcome in Japanese critically ill patients显示文摘	Nakada TA Hirasawa H Oda S	2005	J Surg Res2005，129，2：	1
9	Fluid resuscitation in septic shock:a positive fluid balance and elevated central venous pressure are associated with increased mortality显示文摘	Boyd JH Forbes J Nakada TA	2011	Crit Care Med2011，39，2：	1
10	Fluid resuscitation in septic shock: a positive fluid balance and elevated central venous pressure are associated with increased mortality显示文摘	Boyd JH Forbes J Nakada TA	2011	Crit Care Med2011，39，2：	1
11	Fluid resuscitation inseptic shock : a positive fluid balance and elevated central venouspressure are associated with increased mortality 显示文摘	Boyd JH Forbes J Nakada TA	2011	Crit CareMed2011，39，2：	1
12	Differential pattern of cell-surface and soluble TREM-1 between sepsis and SIRS 显示文摘	Oku R Oda S Nakada TA	2013	Cytokine2013，61，1：	1
13	Fluid resuscitation in septic shock: a positive fluid balance and elevated central venous pressure are associated with increased mortality 显示文摘	BOYD JH FORBES J NAKADA TA	2011	Crit Care Med2011，39，2：	1
14	Fluid resuscitation in septic shoek:a postive fluid balance and elevated central venous pressure are associated with increased mortality 显示文摘	Boyd JH Forbes J Nakada TA	2011	Crit Care Med2011，39，2：	1
15	Differential pattern of cell-surface and soluble TREM-1 between sepsis and SIRS显示文摘	Oku R Oda S Nakada TA	2013	Cytokine2013，61，1：	1
16	Normal-range blood lactate concentration in septic shock is prognostic and predictive显示文摘	Wacharasint P Nakada TA Boyd JH		0，，：	1
17	Fluid resuscita- tion in septic shock: a positive fluid balance and elevat- ed central venous pressure are associated with increased mortality显示文摘	Boyd JH Forbes J Nakada TA	2011	Crit Care Med2011，39，2：	1
18	Fluid resuscitation in septic shock : A positive fluid balance and elevated central venous pressure are associated with increased mortality 显示文摘	Boyd JH Forbes J Nakada TA	2011	Crit Care Med2011，39，2：	1
19	Fluid resuscitation in septic shock:a positive fluid balance and elevated central venous pressure are associated with increased mortality显示文摘	Boyd JH Forbes J Nakada TA		0，，02：	1
20	Fluid resuscitation in septic shock: a positive fluid balance and elevated central venous pressure are associated with increased mortality显示文摘	Boyd JH Forbes J Nakada TA	2011	Crit Care Med2011，39，2：	1

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