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| 1 | Effect of biliary obstruction and internal biliary drainage on hepatic cytochrome P450 isozymes in rats显示文摘AIM: To investigate the total cytochrome P450 (CYP) content, microsomal mixed-function oxidase (MFO) activity, and expression of mRNAs for various CYP isozymes in a simple rat model of reversible obstructive jaundice. METHODS: Obstructive jaundice was created in male rats by causing bile duct obstruction with polyester tape. In another group of rats, bile duct obstruction was followed by internal biliary drainage after releasing the tape. The expression of various CYP isozyme mRNAs was semi-quantitatively assessed by competitive RT- PCR. RESULTS: The total CYP content and microsomal MFO activity showed a significant decrease after biliary obstruction, but returned to respective control levels after biliary drainage. A marked reduction in the expression of CYP1A2, 2B1/2, 2C11, 2E1, 3A1, and 3A2 mRNA was detected during biliary obstruction, while expression increased significantly toward the control level after biliary drainage. Although expression of CYP4A1 mRNA showed no reduction during biliary obstruction, it still increased significantly after biliary drainage. CONCLUSION: These results suggest that not only obstructive jaundice, but also the subsequent internal biliary drainage may affect regulatory medications of the synthesis of individual CYP isozymes differently. | Shintaro Fukushima Hiroyasu Okuno Nobuyuki Shibatani Yoshitsugu Nakahashi Toshihito Seki Kazuichi Okazaki | 2008 | World Journal of Gastroenterology2008，14，16： | 7 |
| 2 | Bare metal stent thrombo- sis and in - sent neoatheroselerosis 显示文摘 | Yamaji K Inoue K Nakahashi T | 2012 | Cire Cardiovase Interv2012，5，1： | 1 |
| 3 | On the efficient application of Weighted Essentially Nonoscillatory scheme 显示文摘 | Su X Sasaki D Nakahashi K | 2013 | Inter- national Journal for Numerical Methods in Fluids2013，71，2： | 1 |
| 4 | An analysis of waist-nipper factors that affect subjective feeling and physiological response-for the design of comfortable women's foundation garments显示文摘 | MIYUKI Nakahashi HARUMI Morooka NORIKO Nakamura | 2005 | Journal of the Textile Machinery Society of Japan2005，61，1： | 1 |
| 5 | Long-term survival achieved by repeated resections of metachronous pulmonary and adrenal metastases of alpha-fetoprotein-producing gastric cancer:report of a case显示文摘 | Nakahashi C Kinoshita T Konishi M | 2004 | Surg Today2004，34，9： | 1 |
| 6 | Chemical State of Nitrogen Atoms in Carbon Films Prepared from Nitrogen- containing Polymer Films显示文摘 | NAKAHASHI T KONNO H INAGAKI M | 1998 | Solid State Ionics1998，，： | 1 |
| 7 | Possible participation of Fas-mediated apoptosis in the mechanism of atherosclerosis显示文摘 | Fukuo K Nakahashi T Nomura S | 1997 | Gerontology1997，431，： | 1 |
| 8 | Stereochemical study of a novel tautomeric furanone,homofuraneol显示文摘 | MONDE K NAKAHASHI A MIURA N | | 0，，： | 1 |
| 9 | Three-dimensional adaptive grid method显示文摘 | Nakahashi K Deiwert G S | 1986 | AIAA Journal1986，24，6： | 1 |
| 10 | Clothing pressure and wear feeling at under-bust part on a push-up type brassiere显示文摘 | Morooka H Fukuda R Nakahashi M | 2005 | Sen''I Gakkaishi2005，61，2： | 1 |
| 11 | Vascular endothelialcells synthesize and secret brain-derived neurotrophic factor显示文摘 | Nakahashi T Fujimura H Altar CA | 2000 | FEBS Lett2000，470，： | 1 |
| 12 | Interfacial reactions between sapphire and silver-coppertitanium thin film filler metal显示文摘 | Suenaga S Nakahashi M Maruyama M Fukasawa T | 1997 | Journal of the American Ceramic Society1997，80，2： | 1 |
| 13 | Interfacial reactions between sapphire and silver-copper-titanium thin film filler metal 显示文摘 | SUENAGA S NAKAHASHI M MARUYAMA M FUKASAWA T | 1997 | Journal of American Ceramic Society1997，80，： | 1 |
| 14 | A robust method for unstructured volume/surface mesh movement显示文摘 | Murayamaa M Nakahashi K Matsushima K | 2003 | Transactions of the Japan Society for Aeronautical and Space Sciences2003，46，152： | 1 |
| 15 | Aerodynamic design of wing-body-nacelle-pylon configuration显示文摘 | S Koc HJ Kim K Nakahashi | 2005 | AIAA2005，，： | 1 |
| 16 | Comparison of in vitro anticancer chemosensitivity between human squamous cell carainca and adenocarcinoma显示文摘 | Kusumoto T Sakaguchi Y Nakahashi J | 1992 | Oncology1992，49，5： | 1 |
| 17 | Vascular endothelial cells synthesize and secrete brain-derived neurotrophic factor显示文摘 | Nakahashi T Fujimura H Altar CA | 2000 | FEBS Lett2000，470，2： | 1 |
| 18 | Aerodynamic Design of a Medium Size Blended-wing-body Airplane显示文摘 | Tjoetjoek Eko Pambagjo Kazuhiro Nakahashi Shigeru Obayashi Kisa Matsushima | 2001 | AIAA-2001-01292001，0129，： | 1 |
| 19 | Anatomic evaluation of postural bronchial drainage of the lung with special reference to patients with tracheal intuhations 显示文摘 | Nakahashi N Murakaki G | 2004 | Chest2004，125，3： | 1 |
| 20 | The combination of gly- cyrrhizin and lamivudine can reverse the cisplatin resistance in hepato- cellular carcinoma ceils through inhibition of multidrug resist-ance-as- sociated proteine显示文摘 | Wakamatsu T Nakahashi Y Hachimine D | 2007 | Int J 0ncol2007，31，6： | 1 |
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