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| 1 | Sirtuins and nonalcoholic fatty liver disease显示文摘Mammalian sirtuins are seven members belonging to the silent information regulator 2 family, a group of Class Ⅲ histone/protein deacetylases. Sirtuins(SIRT 1-7) have different subcellular localization and function and they regulate cellular protein function through various posttranslational modifications. SIRT1 and 3, the most studied sirtuins, use the product of cellular metabolism nicotinamide adenine dinucleotide as a cofactor to post-translationally deacetylate cellular proteins and consequently link the metabolic status of the cell to protein function. Sirtuins have been shown to play a key role in the development and rescue of various metabolic diseases including non-alcoholic fatty liver disease(NAFLD). NAFLD is currently the most chronic liver disease due mainly to high-calorie consumption and lower physical activity. No pharmacological approach is available to treat NAFLD, the current recommended treatment are lifestyle modification such as weight loss through calorie restriction and exercise. Recent studies have shown downregulation of sirtuins in human as well as animal models of NAFLD indicating an important role of sirtuins in the dynamic pathophysiology of NAFLD. In this review, we highlight the recent knowledge on sirtuins, their role in NAFLD and their unique potential role as novel therapeutic target for NAFLD treatment. | Fatiha Nassir Jamal A Ibdah | 2016 | World Journal of Gastroenterology2016，22，46： | 19 |
| 2 | Role of mitochondria in alcoholic liver disease显示文摘Alcohol abuse is the leading cause of liver related morbidity and mortality.Chronic or binge alcohol drinking causes hepatic steatosis which can develop to steatohepatitis,cirrhosis and ultimately hepatocellular carcinoma.The pathogenesis of alcoholic liver disease(ALD)is poorly characterized,however several recent studies point to a major role of mitochondria in this process.Mitochondria play a crucial role in cellular energy metabolism and in reactive species formation.Alcohol treatment causes mitochondrial DNA damage,lipid accumulation and oxidative stress.Studies in both animal models and in humans showed that alcohol administration causes changes in the mitochondrial morphology and function suggesting a role of these changes in the pathogenesis of ALD.We review recent findings on mechanisms by which alcohol negatively impacts mitochondrial biogenesis and function and we will discuss the specific intracellular pathways affected by alcohol consumption.Interestingly,recent findings indicate that a large number of mitochondrial proteins are acetylated and that mitochondrial proteins acetylation and sirtuins are modulated by alcohol.Un-derstanding the mechanisms behind alcohol mediated impaired mitochondrial biogenesis and function may help identify potential therapeutic targets for treating ALD in humans. | Fatiha Nassir Jamal A Ibdah | 2014 | World Journal of Gastroenterology2014，20，9： | 18 |
| 3 | Multilocular cystic renal cell carcinoma:a series of 12 cases and review of the literature显示文摘 | Nassir A Jollimore J Gupta R | 2002 | Urology2002，60，3： | 1 |
| 4 | BLastocystis hominis as acause of hypoalbuminemia and anasarca显示文摘 | Nassir E A wad J Abel AB | 2004 | Eur J Clin MicrobiolInefect Dis2004，23，5： | 1 |
| 5 | Multilocular cystic renal cell carcinoma:a series of 12cases and review of the literature显示文摘 | Nassir A Jollimore J Gupta R | 2002 | Urology2002，60，3： | 1 |
| 6 | CD36 deficiency impairs intestinal lipid secretion and clear- ance of chylomicrons from the blood 显示文摘 | DROVER V A AJMAL M NASSIR F | 2005 | The Journal of Clinical Investigation2005，115，5： | 1 |
| 7 | Muhilocular cystic renal cell carcinoma :a series of 12 cases and review of the literature显示文摘 | Nassir A Jollimore J Gupta R | 2002 | Urology2002，60，3： | 1 |
| 8 | Microalbuminuria in non-diabetic patients with unstable angina/non ST-segment eleva- tion myocardial infarction显示文摘 | AL-SAFFAR H B NASSIR H MITCHELL A | 2015 | BMC Res Notes2015，8，： | 1 |
| 9 | Multilocular cystic renal cell eareinoma:a series of 12 eases and review of the literature显示文摘 | Nassir A Jollimore J Gupta R | 2002 | Urology2002，60，3： | 1 |
| 10 | Multi locular cystic renal cell carcinoma: a series of I2 cases and review of the litera- ture显示文摘 | NASSIR A JOLLIMORE J GUPTA R | 2002 | Urology2002，60，3： | 1 |
| 11 | Multilocular cystic renal cell carcinoma: a series of 12 cases and review of the literature 显示文摘 | Nassir A Jollimore J Gupta R | 2002 | Urology2002，60，： | 1 |
| 12 | Blastoeystis hominis as a cause of hypoalbuminemia and anasarea显示文摘 | Nassir E Awad J Abel A B | 2004 | Eur J Clin Micro- biol Inefeet Dis2004，23，5： | 1 |
| 13 | Multilocular cystic renal cell carcinoma: a series of 12 cases and re view of the literature显示文摘 | Nassir A Jollimore J Gupta R | 2002 | Urology2002，60，： | 1 |
| 14 | Multilocular cystic renal cell carcinoma: a series of 12cases and review of the literature 显示文摘 | Nassir A Jollimore J Gupta R | 2002 | Urolo gy2002，60，3： | 1 |
| 15 | Investigation of rolls size effects on hot ring rolling process by coupled thermo mechanical 3D-FEA显示文摘 | NASSIR A ALI B | 2010 | Journal of Materials Processing Technology2010，210，10： | 1 |
| 16 | Multilocrlar cystic renal cell carcinoma: a series of 12 cases and review of the literature 显示文摘 | Nassir A Jollimore J Gupta R | 2002 | Urology2002，60，3： | 1 |
| 17 | The accuracy of profit forecasts of Malaysian IPOs显示文摘 | Mohamad S Nassir A Kuing T.K Artff M | | 0，，02： | 1 |
| 18 | Multilocular cystic renal cell carcinoma:a series of 12cases and review of the literature显示文摘 | Nassir A Jollimore J Gupta R | 2002 | Urology2002，60，3： | 1 |
| 19 | Conventional vs Islamic bond announcements: the effects on shareholders’ wealth显示文摘 | ASHARI Z CHUN L NASSIRE A | 2009 | International Journal of Business and Management2009，4，6： | 1 |
| 20 | Multilocular cystic renal cell carcinoma:a series of 12 cases and review of the literature显示文摘 | Nassir A Jollimore J Gupta R | | 0，，03： | 1 |
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