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| 1 | Pharmacogenomics in colorectal cancer: The first step for individualized-therapy显示文摘Interindividual differences in the toxicity and response to anticancer therapies are currently observed in practically all available treatment regimens. A goal of cancer therapy is to predict patient response and toxicity to drugs in order to facilitate the individualization of patient treatment. Identification of subgroups of patients that differ in their prognosis and response to treatment could help to identify the best available drug therapy according the genetic profile. Several mechanisms have been suggested to contribute to chemo-therapeutic drug resistance: amplification or overexpression of membrane transporters, changes in cellular proteins involved in detoxification or in DNA repair, apoptosis and activation of oncogenes or tumor suppressor genes. Colorectal cancer (CRC) is regarded as intrinsically resistant to chemotherapy. Several molecular markers predictive of CRC therapy have been included during the last decade but their results in different studies complicate their application in practical clinical. The simultaneous testing of multiple markers predictive of response could help to identify more accurately the true role of these polymorphisms in CRC therapy. This review analyzes the role of genetic variants in genes involved in the action mechanisms of the drugs used at present in colorectal cancer. | Eva Bandrés Ruth Zárate Natalia Ramirez Ana Abajo Nerea Bitarte Jesus García-Foncillas | 2007 | World Journal of Gastroenterology2007，13，44： | 4 |
| 2 | Moving forward in colorectal cancer research, what proteomics has to tell显示文摘Colorectal cancer is the third most common cancer and is highly fatal. During the last several years, research has been primarily based on the study of expression profiles using microarray technology. But now, investigators are putting into practice proteomic analyses of cancer tissues and cells to identify new diagnostic or therapeutic biomarkers for this cancer. Because the proteome reflects the state of a cell, tissue or organism more accurately, much is expected from proteomics to yield better tumor markers for disease diagnosis and therapy monitoring. This review summarizes the most relevant applications of proteomics the biomarker discovery for colorectal cancer. | Nerea Bitarte Eva Bandrés Ruth Zárate Natalia Ramirez Jesus Garcia-Foncillas | 2007 | World Journal of Gastroenterology2007，13，44： | 3 |
| 3 | University effects on regional innovation 显示文摘 | Robin C Natalia Z | 2013 | Research Policy2013，42，3： | 1 |
| 4 | Cross-Cultural Validation of Fear of Happi- ness Scale Across 14 National Groups显示文摘 | Joshanloo M Lepshokova Z K Panyusheva T Natalia A Poon W C Yeung V W | 2014 | Journal of Cross-Cultural Psychology2014，45，2： | 1 |
| 5 | Universal primer cocktails for fish DNA barcoding 显示文摘 | Natalia V I Tyler S Z Robert H H | 2007 | Molecular Ecology Notes2007，7，4： | 1 |
| 6 | The pollution haven hypothesis: a geographic economy model in comparative study 显示文摘 | NATALIA Z SONIA B K | 2008 | Ssrn Electronic Journal2008，，73： | 1 |
| 7 | The pollution haven hypothesis: a geo- graphic economy model in a comparative study 显示文摘 | SONIA B K NATALIA Z G | 2008 | Working Paper2008，，2： | 1 |
| 8 | Undergraduate medical education in general practice / family medicine throughout Europe -- a descriptive study显示文摘 | Brekke M Francesco C Natalia Z | 2013 | BMC Med Educ2013，13，： | 1 |
| 9 | Comparative 16S rRNA analysis of lake bacterioplankton reveals globally distributed phylogenetic clusters including an abundant group of aetinobacteria显示文摘 | FRANK O G EYGENY Z NATALIA B | 2000 | Applied and Environmental Microbiology2000，66，11： | 1 |
| 10 | The role of medium radiation dose on microbiological safety and shelf-life of some traditional soups显示文摘 | IRAWATI Z NATALIA L NURCAHYA C M | 2007 | Radiation Physics and Chemistry2007，76，1112： | 1 |
| 11 | The influence of desicca- tion, cryopreservation and rehydration on the survival of polyem- bryonic Citrus seeds 显示文摘 | Natalia G Alicia C Noemi Z | 2012 | Cryobiology2012，65，3： | 1 |
| 12 | X-ray topographic study of growth defects of trans-stilbene crystals grown fromsolutions显示文摘 | Helmut K Natalia Z Leslie C | 2015 | Journal of Crystal Growth2015，429，11： | 1 |
| 13 | Cephalometfic measurements from 3D reconstructed images compared with conventional 2D ima- ges显示文摘 | Natalia Z Jose ML Rosa C | 2011 | Angle Orthod2011，81，5： | 1 |
| 14 | Enhanced gas separation performance of dual-layer hollow fiber membranes via substructure resistance reduction using mixed matrix materials显示文摘 | Natalia W Shaohua D Z Tai S C | 2007 | Journal of Membrane Science2007，306，： | 1 |
| 15 | Chronic constipation:Lessons from animal studies显示文摘 | NATALIA Z NICK J SPENCER | | 0，，： | 1 |
| 16 | Device-based neuromodulation for cardiovascular diseases and patient’s age显示文摘The autonomic nervous system plays an important role in the pathogenesis of cardiovascular diseases.With aging,autonomic activity changes,and this impacts the physiological reactions to internal and external signals.Both sympathetic and parasympathetic responses seem to decline,reflecting functional and structural changes in nervous regulation.Although some investigators suggested that both the sympathetic and parasympathetic activities were suppressed,others found that only the parasympathetic activity was suppressed while the sympathetic activity increased.In addition,cardiac innervation progressively diminishes with aging.Therefore,one may suggest that neuromodulation interventions may have different effects,and older age groups can express an attenuated response.This article aims to discuss the effect of device-based neuromodulation in different cardiovascular diseases,depending on the patient’s age.Thus,we cover renal denervation,pulmonary artery denervation,baroreceptor activation therapy,vagus nerve stimulation,spinal cord stimulation,ganglionated plexi ablation for the management of arterial and pulmonary hypertension,heart failure,angina and arrhythmias.The results of many clinical studies appeared to be unconvincing.In view of the low rate of positive findings in clinical studies incorporating neuromodulation approaches,we suggest the underestimation of advanced age as a potential contributing factor to poorer response.Analysis of outcomes between different age groups in clinical trials may shed more light on the true effects of neuromodulation when neutral/ambiguous results are obtained. | Evgeny N Mikhaylov Nigar Z Gasimova Natalia N Belyaeva Heber Ivan Condori Leandro Aleksandr D Vakhrushev Evgeny V Shlyakhto | 2022 | Journal of Geriatric Cardiology2022，19，11： | 0 |
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