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| 1 | Effectiveness of royal jelly supplementation in glycemic regulation:A systematic review显示文摘BACKGROUND Royal jelly(RJ)has been observed to have therapeutic properties in diabetic individuals,including the reduction of high blood sugar.This systematic review synthesized existing evidence to investigate the effectiveness of RJ supplementation in managing measures of blood glucose.AIM To determine the effectiveness of RJ supplementation on glycemic responses in healthy and non-insulin dependent diabetic adults,as well as animal models of diabetes.METHODS This was a systematic review employing the PRISMA strategy.Peer-reviewed,published articles were extracted from several databases using key words related to target population,intervention and outcome and hand-selected for inclusion.Included articles proceeded to data extraction phase,where information on target parameters and effectiveness of treatment was summarized.Following this,the risk of bias for each included study was evaluated.Then,the long-term and immediate effectiveness of RJ supplementation in glycemic control were assessed using the Grading of Recommendations,Assessment,Development and Evaluations(GRADE)tool,which rates the quality of evidence.RESULTS Of 168 articles extracted from database searching,eighteen were included for analysis in this systematic review.Across the studies,studied populations,intervention styles and outcome measures were largely heterogeneous.Despite this,the results in studies indicate a general trend of positive effect of RJ in glycemic regulation in vitro and in vivo.Additionally,some dose-dependent glycemic effects were observed,along with some large effect sizes.The risk of bias for human and animal studies is generally low-unclear risk,although lack of blinding is a serious concern in both categories.Overall,as per the GRADE tool,the quality of evidence is low,and very low for long-term and immediate effectiveness of RJ,respectively.A major limitation affecting evidence quality is the heterogeneity among included studies.Fasting blood glucose and glucose clearance appear to be most affected by RJ supplementation.CONCLUSION Quality of evidence suggesting that RJ is an effective modulator of glycemic regulation is low for long-term effects of RJ,and very low for immediate effects. | Kamel Omer Maxwell J Gelkopf Genevieve Newton | 2019 | World Journal of Diabetes2019，10，2： | 3 |
| 2 | Effective- ness of Grass Strips to Filter Catfish Pond Effluent 显示文摘 | Ghate S R Gary J Burtle George Vellidis G Larry Newton | 1997 | Aquacultural Engineering1997，16，： | 2 |
| 3 | Effect of two breathing exercises(Buteyko and pranayama) in asthma:a randomised controlledtrial显示文摘 | COOPER S OBORNE J NEWTON S | 2003 | Thorax2003，58，： | 1 |
| 4 | Cyclosporine-associated chronic nephropathy显示文摘 | Myers BD Ross J Newton LN | 1984 | N Engl J Med1984，311，： | 1 |
| 5 | Magnetic field and shock effects and remanent magnetization in a hypervelocity impact experiment显示文摘 | Srnka L J Martelli G Newton G | 1979 | Earth and Planetary Science Letters1979，42，1： | 1 |
| 6 | Tourism Destination Competitiveness : A Quantitative Approach 显示文摘 | Enright M J Newton J | 2004 | Tourism Management2004，25，6： | 1 |
| 7 | Heat transfer measurements from a smooth NACA0012 airfoil 显示文摘 | Poinsatte P E Van Fossen G J Newton J E | 1991 | Journal of Aircraft1991，28，12： | 1 |
| 8 | Maternal and neonataltetanus显示文摘 | ThwaitesC L Beeching N J Newton C R | 2015 | Lancet2015，385，9965： | 1 |
| 9 | A guide to the natural history of freshwater lake bacteria显示文摘 | NEWTON R J JONES S E EILER A | 2011 | Microbiology and Molecular Biology Reviews2011，75，1： | 1 |
| 10 | Effect of HPMC-E15 LV premiumPolymer on release profile and compression characteristics of chitosan/pectin colon targeted mesalamine matrix tablets and in vitro study on effect of pH impact on the drug release profile 显示文摘 | Newton A M J Prabakaran Lakshmanan | 2014 | Recent Patents on Drug Delivery & Formulation2014，8，： | 1 |
| 11 | Heart rate and blood pressure changes during gastroscopy in healthy older subjects显示文摘 | NEWTON J L | 2004 | Gerontology2004，50，3： | 1 |
| 12 | A practical vision for optical transport networking 显示文摘 | Alferness Rod C Bonenfant Paul A Newton Curtis J | 1999 | Bell Labs Technical Journal1999，4，1： | 1 |
| 13 | Minimizing adverse effects on pa-tients of involuntary relocation from long-stay wards to community resi-dences显示文摘 | Farhall J Trauer T Newton R | 2003 | Psychiatr Serv2003，54，7： | 1 |
| 14 | Long-term use of cholesterol-lowering drugs and cancer incidence in a large united states cohort显示文摘 | Jacobs E J Newton C C Thun M J | 2011 | Cancer Res2011，71，5： | 1 |
| 15 | Multiehromophorie f6rster resonance energy transfer from B800 to B850 in the light harvesting complex2 evidence for subtle energetic optimization by purple bacteria显示文摘 | JANG S NEWTON M SILBEY J | 2007 | The Journal of Physical Chemistry B2007，111，24： | 1 |
| 16 | Adenosine protected against pulmonary edema through transporter and receptor A2-mediated endothelial barrier enhancement显示文摘 | Lu Q Harrington EO Newton J | 2010 | Am J Physiol Lung Cell Mol Physiol2010，298，6： | 1 |
| 17 | The role of psychological factors in response to treatment in neurocardiogenic (vasovagal) syncope 显示文摘 | Gracie J Newton JL Norton M | 2006 | Europace2006，8，8： | 1 |
| 18 | The end Triassic massextinction record of Williston Lake, British Columbia 显示文摘 | Wignall P B Zonneveld J P Newton R J Amor K Sephton M A Hartley S | 2007 | Palaeogeogr Palaeoclimatol Palaeoecol2007，253，34： | 1 |
| 19 | A novel method for the visualization of the in situ mucus layer in rat and man显示文摘 | Jordan N Newton J Pearson J | 1998 | Clin Sci (Lond)1998，95，1： | 1 |
| 20 | Quantitative determination of an extremely polar compound allantoin in human urine by LC-MS/MS based on the separation on a polymeric amino column显示文摘 | Berthemy A Newton J Wu D | 1999 | J Pharm Biomed Anal1999，19，34： | 1 |
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