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| 1 | Schistosoma mansoni proteins attenuate gastrointestinal motility disturbances during experimental colitis in mice显示文摘AIM:To investigate the therapeutic effect of Schistosoma mansoni(S.mansoni) soluble worm proteins on gastrointestinal motility disturbances during experimental colitis in mice. METHODS:Colitis was induced by intrarectal injection of trinitrobenzene sulphate(TNBS) and 6 h later,mice were treated ip with S.mansoni proteins.Experiments were performed 5 d after TNBS injection.Inflammationwas quantified using validated inflammation parameters. Gastric emptying and geometric center were measured to assess in vivo gastrointestinal motility.Peristaltic activity of distal colonic segments was studied in vitro using a modified Trendelenburg set-up.Cytokine profiles of T-lymphocytes isolated from the colon were determined by real time reverse transcriptase-polymerase chain reaction. RESULTS:Intracolonic injection of TNBS caused severe colitis.Treatment with S.mansoni proteins significantly ameliorated colonic inflammation after 5 d.TNBS did not affect gastric emptying but significantly decreased the geometric center and impaired colonic peristaltic activity 5 d after the induction of colitis.Treatment with S.mansoni proteins ameliorated these in vivo and in vitro motility disturbances.In addition,TNBS injection caused a downregulation of effector T cell cytokines after 5 d,whereas a S.mansoni protein effect was no longer observed at this time point. CONCLUSION:Treatment with S.mansoni proteins attenuated intestinal inflammation and ameliorated motility disturbances during murine experimental colitis. | Nathalie E Ruyssers Benedicte Y De Winter Joris G De Man Natacha D Ruyssers Ann J Van Gils Alex Loukas Mark S Pearson Joel V Weinstock Paul A Pelckmans Tom G Moreels | 2010 | World Journal of Gastroenterology2010，16，6： | 11 |
| 2 | Contractile apparatus dysfunction early in the pathophysiology of diabetic cardiomyopathy显示文摘Diabetes mellitus significantly increases the risk of cardiovascular disease and heart failure in patients.Independent of hypertension and coronary artery disease,diabetes is associated with a specific cardiomyopathy,known as diabetic cardiomyopathy(DCM).Four decades of research in experimental animal models and advances in clinical imaging techniques suggest that DCM is a progressive disease,beginning early after the onset of type 1 and type 2 diabetes,ahead of left ventricular remodeling and overt diastolic dysfunction.Although the molecular pathogenesis of early DCM still remains largely unclear,activation of protein kinase C appears to be central in driving the oxidative stress dependent and independent pathways in the development of contractile dysfunction.Multiple subcellular alterations to the cardiomyocyte are now being highlighted as critical events in the early changes to the rate of force development,relaxation and stability under pathophysiological stresses.These changes include perturbed calcium handling,suppressed activity of aerobic energy producing enzymes,altered transcriptional and posttranslational modification of membrane and sarcomeric cytoskeletal proteins,reduced actin-myosin cross-bridge cycling and dynamics,and changed myofilament calcium sensitivity.In this review,we will present and discuss novel aspects of the molecular pathogenesis of early DCM,with a special focus on the sarcomeric contractile apparatus. | Mark T Waddingham Amanda J Edgley Hirotsugu Tsuchimochi Darren J Kelly Mikiyasu Shirai James T Pearson | 2015 | World Journal of Diabetes2015，6，7： | 10 |
| 3 | Treatment of relapsing autoimmune pancreatitis with immunomodulators and rituximab: the Mayo Clinic experience显示文摘 | Phil A Hart Mark D Topazian Thomas E Witzig Jonathan E Clain Ferga C Gleeson Robin R Klebig Michael J Levy Randall K Pearson Bret T Petersen Thomas C Smyrk Aravind Sugumar Naoki Takahashi Santhi S Vege Suresh T Chari | 2013 | Gut2013，，11： | 2 |
| 4 | Treatment of relapsing autoimmune pancreatitis with immunomodulators and rituximab: the Mayo Clinic experience显示文摘 | Phil A Hart Mark D Topazian Thomas E Witzig Jonathan E Clain Ferga C Gleeson Robin R Klebig Michael J Levy Randall K Pearson Bret T Petersen Thomas C Smyrk Aravind Sugumar Naoki Takahashi Santhi S Vege Suresh T Chari | 2013 | Gut2013，，11： | 2 |
| 5 | Genotypic differences in the production and partitioning of carbohydrates between roots and shoots of wheat grown under zinc or manganese deficiency显示文摘 | Pearson J N Rengel Z | 1997 | Annals of Botany1997，80，： | 2 |
| 6 | Improved tools for biological sequence comparison 显示文摘 | PEARSON W R LIPMAN D J | 1988 | Proc Natl Acad Sci USA1988，85，： | 2 |
| 7 | Evidence for two rhabdoviruses in taro ( Colocasia esculenta) in the Pacific region显示文摘 | Pearson M N Jackson G V H Saelea J | 1999 | Austral Plant Pathol1999，28，3： | 2 |
| 8 | Active control of helicopter vibration 显示文摘 | Pearson J T Goodall R M Lyndon I | 1994 | Computing & Control Engineering Journal1994，5，6： | 1 |
| 9 | Concrete penetration by eroding projectiles: experiments and analysis 显示文摘 | Gold V M Vrasis G C Pearson J C | 1996 | Journal of Engineering Mechanics1996，122，2： | 1 |
| 10 | The role of the purchasing function: toward team participation显示文摘 | Pearson J N | 1994 | International Journal of Distribution of Purchasing a nd Materials Management1994，29，3： | 1 |
| 11 | Combined histopathological and molecular cytogenetic stratification of medulloblastoma patients 显示文摘 | Lamont J M McManamy C S Pearson A D | 2004 | Clin Cancer Res2004，10，： | 1 |
| 12 | Nanotechnology:awareness and societal concerns显示文摘 | Sheetz T Vidal J Pearson TD | 2005 | Technology in Society2005，27，3： | 1 |
| 13 | Partial discharge diagnostics for gas insulated substation显示文摘 | PEARSON J S FARISH O HAMPTON B F | 1995 | IEEE Transactions on Dielectrics and Electrical Insulation1995，2，5： | 1 |
| 14 | Development of a tool for measuring and analyzing computer user satisfaction 显示文摘 | Bailey J E Pearson S W | 1983 | Management science1983，，53： | 1 |
| 15 | A phase I study of docetaxel as a radio-sensitizer for locally advanced squamous cell cervical cancer显示文摘 | Alvarez E A Wolfson A H Pearson J M | 2009 | Gynecol Oncol2009，113，2： | 1 |
| 16 | Susceptibility testing: accurate and reproducible minimum inhibitory concentration(MIC) and non-inhibitory concentmtion(NIC) values 显示文摘 | Lambert R J Pearson J | 2000 | Journal of Applied Microbiology2000，88，： | 1 |
| 17 | Video-rate image correlation processor显示文摘 | Pearson J J Hines D C Golosman S | | 0，，： | 1 |
| 18 | Distribution and remobilization of Zn and Mn during grain development in wheat显示文摘 | Pearson J N Rengel Z | | 0，，12： | 1 |
| 19 | Predicting species distributions from small numbers of occurrence re- cords:A test case using cryptic geckos in Madagascar 显示文摘 | Pearson R G Raxworthy C J Nakamura M | 2007 | Journal of Biogeography2007，34，1： | 1 |
| 20 | A multiplex qPCR targeting hepato-and neurotoxigenic cyanobacteria of global significance显示文摘 | AL-TEBRINEH J PEARSON L A YASAR S A | 2012 | Harmful Algae2012，15，： | 1 |
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