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| 1 | 亚洲地区肺炎支原体和肺炎衣原体在成人社区获得性肺炎中的流行病学研究显示文摘目的由Malaya大学医学中心牵头进行的非典型病原在亚洲社区获得性肺炎(CAP)患者中的流行病学研究。结果显示,肺炎支原体和肺炎衣原体分别占成人病原的11.4%和5.8%。本研究将对这2种病原所致感染的临床和实验室资料进一步总结分析。方法亚洲7个国家12个研究中心采用统一的检测方法(DNA检测及血清学方法)和判断标准,对16岁以上的CAP患者进行肺炎支原体和肺炎衣原体的检测。结果在急性肺部感染者中,肺炎支原体和肺炎衣原体肺炎的临床表现与其他病原所致者非常相似,并无特征性。肺炎支原体和肺炎衣原体在男性和女性中检出率相仿,但肺炎支原体感染在16至44岁患者中更为多见(22.2%),而肺炎衣原体感染者重症患者相对较多。88例在病程中血清抗体显著增高的肺炎支原体感染者中,48例(54.5%)患者急性期抗体阴性,如果未检测恢复期血清抗体,上述患者则会漏诊;51例肺炎衣原体感染者中急性期血清抗体阴性则较为少见(21.6%)。肺炎支原体和肺炎衣原体既往感染和(或)病原携带率分别为5.7%和7.9%。结论肺炎支原体肺炎和肺炎衣原体肺炎发病率高,诊断困难,因此在亚洲成人CAP抗感染经验治疗时宜选用对这2种病原亦有效的药物。 | 黄海辉 张婴元 汪复 Mediadora SANIEL Marissa ALEJANDRIA Seung-Chul PARK 刘又宁 Po-Ren HSUEH Ahmad M. AZIAH Wing-Hong SETO Cecilia C. L. NGAN Mangunnegoro HADIARTO Subharee SUWANJUTHA Yun-Fong NGEOW Alsagaff HOOD | 2008 | 中国感染与化疗杂志2008，8，2： | 67 |
| 2 | A community-derived classification for extant lycophytes and ferns显示文摘发展史长通知了蕨类植物分类。当我们推断进化的树的能力改善了,针对认出生来的组的分类变得逐渐地预兆、稳定。这里,我们为 lycophytes 和蕨纲植物提供一个现代、全面分类,在下面,利用一条基于社区的途径类水平。我们 monophyly 用作主要标准让 taxa,而且目的识别保存两个广泛地被接受的存在 taxa 和界限并且与我们蕨类植物发展史的理解一致。总共,这个分类对待一在 337 个类, 51 个家庭, 14 目,和二个班估计了 11 916 种类。这个分类没在 lycophyte 和蕨纲植物上作为最后的词被打算分类,而是当前的假设的概括陈述,源于最好的可得到的数据并且在问题由熟悉植物的那些大多数塑造了。我们希望它将在蕨类植物上为最近的文学的那些想要的参考用作一个资源发展史和分类,为指导未来调查的一个框架,和推进讲话的刺激。 | Eric Schuettpelz Harald Schneider Alan R. Smith Peter Hovenkamp Jefferson Prado Germinal Rouhan Alexandre Salino Michael Sundue Thafs Elias Almeida Barbara Parris Emily B. Sessa Ashley R. Field Andre Luis de Gasper Carl J. Rothfels Michael D. Windham Marcus Lehnert Benjamin Dauphin Atsushi Ebihara Samuli Lehtonen Pedro Bond Schwartsburd Jordan Metzgar Li-Bing Zhang Li-Yaung Kuo Patrick J. Brownsey Masahiro Kato Marcelo Daniel Arana Francine C. Assis Michael S. Barker David S. Barrington Ho-Ming Chang Yi-Han Chang Yi-Shan Chao Cheng-Wei Chen De-Kui Chen Wen-Liang Chiou Vinicius Antonio de Oliveira Dittrich Yi-Fan Duan Jean-Yves Dubuisson Donald R. Farrar Susan Fawcett Jose Maria Gabriel y Galan Luiz Armando de Araujo Goes-Neto Jason R. Grant Amanda L. Grusz Christopher Haufler Warren Hauk Hai He Sabine Hennequin Regina Yoshie Hirai Layne Huiet Michael Kessler Petra Korall Paulo H. Labiak Anders Larsson Blanca Leen Chun-Xiang Li Fay-Wei Li Melanie Link-Perez Hong-Mei Liu Ngan Thi Lu Esteban I. Meza-Torres Xin-Yuan Miao Robbin Moran Claudine Massi Mynssens Nathalie Nagalingum Benjamin Ollgaard Alison M. Paul Jovani B. de S. Pereira Leon R. Perrie Monica Ponce Tom A. Ranker Christian Schulz Wataru Shinohara Alexander Shmakov Erin M. Sigel Filipe Soares de Souza Lana da Silva Sylvestre Weston Testo Luz Amparo Triana-Moreno Chie Tsutsumi Hanna Tuomisto IvAn A. Valdespino Alejandra Vasco Raquel Stauffer Viveros Alan Weakley Ran Wei Stina Weststrand Paul G. Wolf George Yatskievych Xiao-Gang Xu Yue-Hong Yan Liang Zhang Xian-Chun Zhang Xin-Mao Zhou | 2016 | Journal of Systematics and Evolution2016，54，6： | 44 |
| 3 | Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma显示文摘 | Chung-Mau Lo Henry Ngan Wai-Kuen Tso Chi-Leung Liu Chi-Ming Lam Ronnie Tung-Ping Poon Sheung-Tat Fan John Wong | 2002 | Hepatology2002，，5： | 7 |
| 4 | Primary squamous cell carcinoma of the rectum: An update and implications for treatment显示文摘AIM: To provide an update on the aetiology, pathogenesis, diagnosis, staging and management of rectal squamous cell carcinoma(SCC).METHODS: A systematic review was conducted according to the preferred reporting items for Systematic Reviews and Meta-Analyses guidelines. A comprehensive search of Ovid MEDLINE was performed with the reference list of selected articles reviewed to ensure all relevant publications were captured. The search strategy was limited to the English language, spanning from 1946 to 2015. A qualitative analysis was undertaken examining patient demographics, clinical presentation, diagnosis, staging, treatment and outcome. The quantitaive analysis was limited to data extracted on treatment and outcomes including radiological, clinical and pathological complete response where available. The narrative and quantitative review were synthesised in concert.RESULTS: The search identified 487 articles in total with 79 included in the qualitative review. The quantitative analysis involved 63 articles, consisting of 43 case reports and 20 case series with a total of 142 individual cases. The underlying pathogenesis of rectal SCC while unclear, continues to be defined, with increasing evidence of a metaplasia-dysplasia-carcinoma sequence and a possible role for human papilloma virus in this progression. The presentation is similar to rectal adenocarcinoma, with a diagnosis confirmed by endoscopic biopsy. Many presumed rectal SCC's are in fact an extension of an anal SCC, and cytokeratin markers are a useful adjunct in this distinction. Staging is most accurately reflected by the tumour-nodemetastasis classification for rectal adenocarcinoma. It involves examining locoregional disease by way of magnetic resonance imaging and/or endorectal ultrasound, with systemic spread excluded by way of computed tomography. Positron emission tomography is integral in the workup to exclude an external siteof primary SCC with metastasis to the rectum. While the optimal treatment remains as yet undefined, recent studies have demonstrated a global shift away from surgery towards definitive chemoradiotherapy as primary treatment. Pooled overall survival was calculated to be 86% in patients managed with chemoradiation compared with 48% for those treated traditionally with surgery. Furthermore, local recurrence and metastatic rates were 25% vs 10% and 30% vs 13% for the chemoradiation vs conventional treatment cohorts.CONCLUSION: The changing paradigm in the treatment of rectal SCC holds great promise for improved outcomes in this rare disease. | Glen R Guerra Cherng H Kong Satish K Warrier Andrew C Lynch Alexander G Heriot Samuel Y Ngan | 2016 | World Journal of Gastrointestinal Surgery2016，8，3： | 5 |
| 5 | A Prospective Study on Fish Bone Ingestion: Experience of 358 Patients显示文摘 | JOHN H. K. NGAN PETER J. FOK EDWARD C. S. LAI FRANK J. BRANICKI JOHN WONG | 1990 | Annals of Surgery1990，，4： | 3 |
| 6 | 慢性阻塞性肺疾病急性加重住院患者的痰微生物族谱与其一年病死率相关显示文摘背景呼吸系统中的微生态失衡可促进气道炎症、损害局部免疫力,在慢性阻塞性肺疾病(慢阻肺)急性加重的发病机制中发挥重要作用。本研究分析了住院慢阻肺急性加重患者的痰微生物族谱与随访后该群患者的1年病死率的相关性。方法本研究收集慢阻肺急性加重住院患者的痰液样本,通过16S rRNA基因测序对微生物族谱进行了评价,最后根据患者1年的生存情况进行分析,应用Cox比例风险回归模型获得相关的风险比(HR)。 | Leitao Filho FS Alotaihi NM Ngan D 张明强 牟向东 | 2019 | 中华结核和呼吸杂志2019，42，4： | 3 |
| 7 | 未行淋巴清扫的早期卵巢癌81例生存率的回顾性分析显示文摘目的:探讨对于因各种原因而未行淋巴清扫的早期卵巢癌患者,若不行二次分期手术,而是给予辅助化疗,其生存率是否会受影响。方法:收集1992年1月—2002年12月所有在香港玛丽医院妇产科就治的、因各种原因未接受淋巴清扫的、肉眼直视观察肿瘤局限于卵巢的Ⅰ期卵巢癌病例进行回顾性分析。结果:有81例患者被纳为研究对象,其中ⅠA期23例,ⅠB期1例,ⅠC期57例。年龄范围21~81岁,平均年龄47岁。随访时间50~179个月,平均随访时间为110个月。其中有64例(79.0%)患者接受了辅助化疗。总的5年生存率和4年无瘤生存率分别为91.4%和85.2%,与文献报道的行淋巴清扫后的结果相近。结论:对于未行淋巴清扫而病变局限于卵巢的Ⅰ期卵巢癌患者,若辅以适当的化疗,可以使她们获得与行淋巴清扫患者同样的生存率。 | 陈金虹 Karen KL CHAN Kar Fai TAM Hextan YS NGAN | 2008 | 肿瘤2008，28，12： | 3 |
| 8 | Neo- and Paleopolyploidy contribute to the species diversity of Asplenium the most species-rich genus of ferns显示文摘Polyploidy 广泛地在植物的进化被看作一个主要过程,但是多倍体种类差异的累积仍然是争论的。一些最近的研究与他们的双祖先相比在 neopolyploids 建议了增加的扑灭风险。多倍体蕨纲植物的高比例被期望主要被 neopolyploids 形成,而 paleopolyploid 种类被预言在整个染色体复制成立的 clades 被聚类。这里,我们由在导出的蕨纲植物家庭 Aspleniaceae 探索 polyploidy 的进化测试这预言。家庭有全球分布并且在所有蕨纲植物之中显示出多倍体 taxa 的最高的频率。测试假设,我们用代表 292 种类的 883 个标本的叶绿体 DNA 序列获得了全面发展史。所有出版染色体计数被印射到这个种系发生的框架上以便探索多倍体的进化。我们 Aspleniaceae 的历史上为几整个染色体复制恢复了证据。超过 tetraploid 水平的多倍体的种系发生的关系建议那 tetraploid Asplenium 种可能在这个家庭的某 clades 作为主要进化播放器代替了他们的双祖先。 | Harald Schneider Hong-Mei Liu Yan-Fen Chang Daniel Ohlsen Leon R. Perrie Lara Shepherd Michael Kessler Dirk N. Karger Sabine Hennequin Jeannine Marquardt Stephen Russell Stephen Ansell Ngan Thi Lu Peris Kamau Josmaily Loriga Ledis Regalado Jochen Heinrichs Atsushi Ebihara Alan R. Smith Mary Gibby | 2017 | Journal of Systematics and Evolution2017，55，4： | 2 |
| 9 | Coexisting epithelioid trophoblastic tumor and choriocarcinoma of the uterus following a chemoresistant hydatidiform mole 显示文摘 | Shen DH Khoo US Ngan HY | 2003 | Arch Pathol Lab Med2003，127，： | 2 |
| 10 | Arteriovenous shunting in hepatocellular carcinoma: Its prevalence and clinical significance显示文摘 | H. Ngan W.C.G. Peh | 1997 | Clinical Radiology1997，，1： | 2 |
| 11 | 上颌交替式快速扩缩后气道的二维和三维变化显示文摘目的:利用头影测量和CBCT三维重建评估上颌快速扩缩后气道变化。方法:选择上颌发育不足的Ⅲ类儿童43例(男20,女23)。患者扩弓矫治器,并按要求扩缩6周。扩缩前后分别拍摄CBCT和头颅侧位片并进行测量分析,所有结果通过配对t检验和Meta回归进行数据分析。结果:上颌扩缩后,SNA、ANS-TVL、PNS-AD1、AD2-PNS、鼻咽腔直径和PNS-Ba长度改变较为明显(P<0.001),Ba-AD1和Ptm-Ba扩弓前后没有明显变化,腭咽和舌咽体积均有明显增大(P<0.005)。HP、SP和SCV平面的横截面积也明显增大(P<0.005),HP平面上气道横截面积和ANS-TVL长度有相关性(r2=0.78).结论:上颌交替式快速扩缩可促进上颌骨向前发育,增加气道容积,明显改善上颌发育不足的Ⅲ类错畸形患儿的通气状况。 | 邓丽嘉 贺红 Peter Ngan | 2016 | 武汉大学学报(医学版)2016，37，6： | 2 |
| 12 | Molecular authentication of Panax species显示文摘 | Ngan F Shaw I C But P P H | 1999 | phytochemistry1999，50，5： | 1 |
| 13 | Cephalometric and occlusal changes following maxillary expansion and protraction 显示文摘 | Ngan P Yiu C Hu A | 1998 | Eur J Orthod1998，20，： | 1 |
| 14 | ProteinChip array profiling for identification of disease- and chemotherapy-associated biomarkers of nasopharyngeal carcinoma 显示文摘 | Cho WC Yip TF Ngan RK | 2007 | Clin Chem2007，53，2： | 1 |
| 15 | Prokineticin-1 (Prok-1) works coordinately with glial cell line derived neurotrophic factor (GDNF) to mediate proliferation and differentiation of enteric neural crest cells显示文摘 | Ngan E S Shum C K Poon H C Sham M H Garcia-Barcelo M M Lui V C | 2008 | Biochim Biophys Acta2008，1783，： | 1 |
| 16 | Reduction of blocking artifacts in image and video coding显示文摘 | Ngan K N Crebbin G | 1999 | IEEE Transactions on Circuits and Systems for Video Technology1999，9，： | 1 |
| 17 | Application of sequence characterized amplified region(SCAR) analysis to authenticate Panax species and their adulterants显示文摘 | Wang J Ha W Y Ngan F N | 2001 | Planta ivied2001，67，8： | 1 |
| 18 | The effect of amifostine on the in vitro cytotoxicity of chemotherapeutic agents in three epithelial ovarian carcinoma cell lines 显示文摘 | NG T Y NGAN H Y CHENG D K | 1999 | Gynecol Oncol1999，75，2： | 1 |
| 19 | The signifiecance of proliferating cell nuclear antigen in human trophoblastic disease:an immunohistochemical study显示文摘 | Cheung A N Ngan N Y Chen W Z | 1993 | Histopathology1993，22，6： | 1 |
| 20 | Neurotransmitters,cytokins and the control of alveolar bone remodeling in orthodontics显示文摘 | Davidovitch Z Nicolay OF Ngan PW | 1988 | Dent clin N Am1988，32，3： | 1 |
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