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| 1 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 2 | FujiⅦ预防正畸患者釉质脱矿的临床评价显示文摘目的 评价并探讨FujiⅦ预防固定正畸过程中釉质脱矿的有效性.方法 选择于吉林大学口腔医院正畸科就诊并需戴用固定矫治器的患者30例,男10例,女20例,年龄范围11~13岁.采用投币法将所需观察的牙齿随机分为实验侧与对照侧.在正畸托槽粘结后于实验侧的上颌侧切牙、尖牙、第一双尖牙/第二双尖牙托槽周围1.5mm范围处涂布FujiⅦ,对照侧不涂.于初戴、矫治后1、3、6及9个月时应用专业数码相机拍摄口内彩色照片,观察实验侧与对照侧各牙位脱矿的变化,记录每个患者矫治不同时段牙面各区域的釉质脱矿指数(enamel decalcification index,EDI).应用SPSS11.5统计学软件进行统计学分析.结果 对照侧平均EDI在矫治1个月时为0.256,3个月时为0.358,6个月时为0.394,9个月时为0.350;而实验侧平均釉质脱矿指数在矫治1个月时为0.194,3个月时为0.222,6个月时为0.186,9个月时为0.144.以上数据表明实验侧平均釉质脱矿指数在矫治后1、3、6及9个月明显低于对照侧(P<0.05).实验侧发生的釉质脱矿程度轻于对照侧,重度脱矿的出现明显少于对照侧.结论 FujiⅦ对固定正畸过程中患者的釉质脱矿具有一定的积极预防作用,但尚不能完全阻止釉质脱矿的发生发展. | 贾亚梅 Hien C Ngo 徐焱 候旭 孙新华 | 2013 | 中华口腔正畸学杂志2013，20，3： | 5 |
| 3 | Finite element analysis of reinforced concrete beams显示文摘 | Ngo D Scordelis A C | 1967 | ACI1967，64，： | 2 |
| 4 | Skin fold thickness at abdomen:a simple anthropometric measurement may compliment metabolic syndrome definition in patients with normal waist circumference显示文摘Backgroud and Objectives Previous studies have reported that skin fold thickness (SF) strongly correlated with insulin resistance in the metabolic syndrome (MetS). In this study, we developed a MetS definition by SF at A8 point (SFA8) on Erdheim diagram(MetSSFA8) in essential hypertensive patients. Subjects and Methods Medical records of 268 essential hypertensive patients (126males and 122 females) were analyzed, including 210 non-diabetic patients (NDM group) and 58 patients with diabetes (DM group).The mean age was 61.4 ± 9.9 and 59.0 ± 11.0 years, respectively. The control group consisted of 90 non-diabetic, non-hypertensive patients with a mean age of 58.0 ± 11.3 years. The proposed MetSSFA8 definition included SFA8 specific values ( ≥30 mm in female and ≥27 mm in male) and at least two of the following: raised triglyceride levels ( ≥1.7 mmol/L), or specific treatment for this lipid abnormality; raised blood pressure (SBP≥130 mmHg and/or DBP≥85 mmHg), or treatment of previously diagnosed hypertension;reduced HDL-cholesterol (< 1.03 mmol/L in men, <1.29 mmol/L in women), or specific treatment for this lipid abnormality; raised fasting plasma glucose (≥5.6 mmol/l), or previously diagnosed DM. Metabolic Syndrome by the National Cholesterol Education Program and International Diabetes Federation definitions were determined with abdominal obesity defined by Asia-Pacific criteria for waist circumference (NCEPA and IDFA). Results The percentage of MetS as defined by NCEPA, IDFA and MetSSFA8 in NDM group was lower than that of NCEPA, IDFA and MetSSFA8 in DM group [OR=7.7 (95%CI, 2.9-20.2) and 2.5 (95%CI, 1.4-4.8) and 2.7(95%CI, 1.3-5.6), respectively] and higher than that of the control group [OR=53.3 (95%CI, 16.7-170.6), 5.8 (95%CI, 2.6-13.2) and18.8 (95%CI, 7.3-48.7), respectively]. The percentage of MetS by NCEPA, IDFA and MetSSFA8 in males in NDM group was lower than the percentage of MetS by NCEPA, IDFA and MetSSFA8 in females in NDM group (50.8% and 77.9%, P< 0.001; 15,9% and 67.2%, P< 0.001; 60.3% and 73.8%, P <0.05, respectively). In subjects with normal WC or both normal WC and BMI, the percentage of MetS by SFAS was higher than that the percentage of MetS by NCEPA (36.9% and 50.8%, P< 0.05 and 36.0% and 51.0%, P< 0.05).The sensitivity, specificity, false positive rate, positive predictive value, negative predictive value of MetSSFA8 assessed with NCEPA definitions were 0.87, 0.73, 0.27, 0.79 and 0.82, respectively. There was a close agreement between MetSSFA8 and NCEPA (The coefficient of Kapa was 0.60, P< 0.001). Conclusions The MetSSFA8 definition was developed which may be useful in order to define and manage MetS in patients with normal WC or normal weight. | Toan C Nguyen Thai Q Ngo Son V Nguyen Hieu T Luong Khoa TA Pham Cong D Nguyen | 2006 | Journal of Geriatric Cardiology2006，3，2： | 2 |
| 5 | Double-stranded RNAin-duces mRNA degradation in Trypanosoma brucei显示文摘 | Tschudi C Gull K | 1999 | Proc Natl AcadSci USA1999，95，14： | 1 |
| 6 | Finite element analysis of reinforced concrete beam显示文摘 | Scordelis A C | 1967 | American Concrete Institute Journal1967，64，3： | 1 |
| 7 | Apoptosis of T lymphocytes invading glioblastomas multiform:a possible tumor defense mechanism显示文摘 | Didenko VV Ngo HN Minchew C | 2002 | J Neurosurg2002，96，3： | 1 |
| 8 | Structure property relationships in pure and acceptor-doped Ba1-xSrxTiO3 thim films for tunable microwave device applications显示文摘 | Cole M W Hbbart C E Ngo | 2002 | Appl Phys Lett2002，92，1： | 1 |
| 9 | One country many cultures: Or- ganizational cultures of finns of different country ori- gins显示文摘 | Lau C M Ngo H Y | 1996 | International Business Review1996，5，5： | 1 |
| 10 | Interference in determination of ammonia with the hypochlorite-alkaline phenol method of berthelot 显示文摘 | Ngo T T Phan A P H Yam C F | 1982 | Analytical Chemistry1982，54，1： | 1 |
| 11 | The m TOR/AKT inhibitor temsirolimus prevents deep infiltrating endometriosis in mice显示文摘 | Leconte M Nicco C Ngo C | 2011 | Am J Pathol2011，179，2： | 1 |
| 12 | Human resource practices and firm performance of multinational corporations : influences of country origin 显示文摘 | Ngo H Y Turban D Lau C M | 1998 | The International Journal of Human Resource Management1998，9，4： | 1 |
| 13 | Finite element analysis of reinforced eoncrete显示文摘 | NGO D SCORDELIS A C | 1972 | ACI1972，64，12： | 1 |
| 14 | The HR system, organizational cu- lture, and product innovation显示文摘 | Lau C M Ngo H Y | 2004 | International Business Review2004，13，6： | 1 |
| 15 | Dividend Initiations and Long-run IPO Performance 显示文摘 | How J C Ngo Y K’Verhoeven P | 2011 | Australian Journal of Management2011，36，2： | 1 |
| 16 | Histone deacetylase(HDAC) inhibitor activation of p21WAF1 involves changes in promoter- associated proteins,including HDAC1显示文摘 | Gui C Y Ngo L Xu W S | 2004 | PNAS2004，101，5： | 1 |
| 17 | Application of beam simulation to scattering at low grazing angles: methodology and validation 显示文摘 | H D Ngo and C L Rino | 1994 | Radio Science1994，29，6： | 1 |
| 18 | Double-stranded RNA indeuces mRNA degradation in Trypanosoma bruceil显示文摘 | NGO H TSCHUDI C CULL K | 1998 | Proceedings of the National Academy of Sciences USA1998，95，14： | 1 |
| 19 | Organizational Attractiveness of Firms in the People's Republic of China: A Person-Organization Fit Perspective 显示文摘 | TURBAN D B LAAU C M NGO H Y | 2001 | Journal Applied Psychology2001，86，2： | 1 |
| 20 | Anti-inflammatory properties of anthraquinones and their relationship with the regulation ofp-glycoprotein function and expression显示文摘 | Choi R J Ngo C T M Bae K | 2013 | Eur J Pharm Sci2013，48，12： | 1 |
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