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| 1 | 椎间盘器官培养模型的建立及临床意义显示文摘目的建立类似于体内生理环境的椎间盘器官培养模型并评估其临床意义。方法研究材料取自10周龄小鼠的腰椎脊柱功能单位,每个脊柱功能单位由椎间盘和两端的部分椎体组成。将小鼠的腰椎脊柱功能单位在培养液和不同浓度的布比卡因溶液中,经过不同时段的培养,通过组织学染色和MTT方法检测椎间盘的组织学变化和细胞活性。结果小鼠椎间盘的组织学特点和细胞活性在培养液中维持4周无明显变化。0.25%布比卡因中培养1h导致25%椎间盘细胞死亡,而浓度为0.5%相同时间培养死亡细胞比例上升至60%。结论小鼠椎间盘经体外器官培养4周,维持了组织结构和细胞功能的完整性。随着布比卡因作用浓度的增加,椎间盘的细胞活性明显降低。 | 王东 董青 NGO Kevin VO Nam | 2011 | 中华医学杂志2011，91，35： | 2 |
| 2 | Transepithelial leak in Barrett's esophagus patients: The role of proton pump inhibitors显示文摘AIM: To determine if the observed paracellular sucrose leak in Barrett's esophagus patients is due to their proton pump inhibitor (PPI) use. METHODS: The in vivo sucrose permeability test was administered to healthy controls, to Barrett's patients and to non-Barrett's patients on continuous PPI therapy. Degree of leak was tested for correlation with presence of Barrett's, use of PPIs, and length of Barrett's segment and duration of PPI use. RESULTS: Barrett's patients manifested a near 3-fold greater, upper gastrointestinal sucrose leak than healthy controls. A decrease of sucrose leak was observed in Barrett's patients who ceased PPI use for 7 d.Although initial introduction of PPI use (in a PPI-na ve population) results in dramatic increase in sucrose leak, long-term, continuous PPI use manifested a slow spontaneous decline in leak. The sucrose leak observed in Barrett's patients showed no correlation to the amount of Barrett's tissue present in the esophagus. CONCLUSION: Although future research is needed to determine the degree of paracellular leak in actual Barrett's mucosa, the relatively high degree of leak observed with in vivo sucrose permeability measurement of Barrett's patients reflects their PPI use and not their Barrett's tissue per se . | Christopher Farrell Melissa Morgan Owen Tully Kevin Wolov Keith Kearney Benjamin Ngo Giancarlo Mercogliano James J Thornton Mary Carmen Valenzano James M Mullin | 2012 | World Journal of Gastroenterology2012，18，22： | 2 |
| 3 | ISSLS Prize Winner: Inhibition of NF-κB Activity Ameliorates Age-Associated Disc Degeneration in a Mouse Model of Accelerated Aging显示文摘 | Luigi A. Nasto Hyoung-Yeon Seo Andria R. Robinson Jeremy S. Tilstra Cheryl L. Clauson Gwendolyn A. Sowa Kevin Ngo Qing Dong Enrico Pola Joon Y. Lee Laura J. Niedernhofer James D. Kang Paul D. Robbins Nam V. Vo | 2012 | Spine2012，，21： | 1 |
| 4 | Investigating the role of DNA damage in tobacco smoking-induced spine degeneration显示文摘 | Luigi A. Nasto Kevin Ngo Adriana S. Leme Andria R. Robinson Qing Dong Peter Roughley Arvydas Usas Gwendolyn A. Sowa Enrico Pola James Kang Laura J. Niedernhofer Steven Shapiro Nam V. Vo | 2013 | The Spine Journal2013，，： | 1 |
| 5 | 不要等待!显示文摘语篇导读
人生如一重大工程,定有截止期限!每日,每周,每月,每年,你皆有机会发奋拼搏。若有想做的事,请立即行动起来!现在还不晚! | Kevin Ngo 郭玉章 | 2018 | 疯狂英语(新策略)2018，0，9： | 0 |
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