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| 1 | Parameters of a severe disease course in ulcerative colitis显示文摘AIM:To detect high risk patients with a progressive disease course of ulcerative colitis(UC) requiring immunosuppressive therapy(IT).METHODS:A retrospective,multicenter analysis of 262 UC patients from eight German tertiary inflammatory bowel disease centres was performed.Patients were divided into two groups depending on the patients need to initiate immunosuppressive therapy in the disease course.A comparison between the two groups was made with regard to demographics,clinical and laboratory parameters obtained within three months after UC diagnosis and the response to first medical therapy.Using this data,a prognostic model was established to predict the individual patients probability of requiring an immunosuppressive therapy.RESULTS:In 104(39.7%) out of 262 patients,UC therapy required an immunosuppressive treatment.Patients in this group were significantly younger at time of diagnosis(HR = 0.981 ± 0.014 per year,P = 0.009),and required significantly more often a hospitalisation(HR = 2.5 ± 1.0,P < 0.001) and a systemic corticosteroid therapy at disease onset(HR = 2.4 ± 0.8,P < 0.001),respectively.Response to steroid treatment was significantly different between the two groups of patients(HR = 5.2 ± 3.9 to 50.8 ± 35.6 compared to no steroids,P = 0.016 to P < 0.001).Furthermore,in the IT group an extended disease(HR = 3.5 ± 2.4 to 6.1 ± 4.0 compared to proctitis,P = 0.007 to P = 0.001),anemia(HR = 2.2 ± 0.8,P < 0.001),thrombocytosis(HR = 1.9 ± 1.8,P = 0.009),elevated C-reactive protein(CRP)(HR = 2.1 ± 0.9,P < 0.001),and extraintestinal manifestations in the course of disease(HR = 2.6 ± 1.1,P = 0.004) were observed.Six simple clinical items were used to establish a prognostic model to predict the individual risk requiring an IT.This probability ranges from less than 2% up to 100% after 5 years.Using this,the necessity of an immunosuppressive therapy can be predicted in 60% of patients.Our model can determine the need for an immunosuppressive drug therapy or if a 'watch and wait' approach is reasonable already early in the treatment course of UC.CONCLUSION:Using six simple clinical parameters,we can estimate the patients individual risk of developing a progressive disease course. | Andreas Stallmach Luisa Nickel Thomas Lehmann Bernd Bokemeyer Martin Bürger Dietrich Hüppe Wolfgang Kruis Susanna Nikolaus Jan C Preiss Andreas Sturm Niels Teich Carsten Schmidt | 2014 | World Journal of Gastroenterology2014，20，35： | 2 |
| 2 | Gastric Bypass Leads to Improvement of Diabetic Neuropathy Independent of Glucose Normalization—Results of a Prospective Cohort Study (DiaSurg 1 Study)显示文摘 | Beat P. Müller-Stich Lars Fischer Hannes G. Kenngott Matthias Gondan Jonas Senft Gabriella Clemens Felix Nickel Thomas Fleming Peter P. Nawroth Markus W. Büchler | 2013 | Annals of Surgery2013，，5： | 2 |
| 3 | Sequence analysis of the capsid protein gene of an isolate of Apple stem grooving virus, and its survey in Southern Brazil显示文摘 | NICKEL O FAJARDO T V M JELKMANN W KUHN G B | 2001 | Fitopatologia Brasileira2001，26，3： | 1 |
| 4 | Predictors of patient responseto antibiotic therapy for the chronic prostatitis/chronic pelvic pain sy-ndrome A prospective multicenter clinical trial显示文摘 | Nickel JC Downey J Johnston B | 2001 | J Urol2001，165，5： | 1 |
| 5 | D-24851,a novel synthetic microtubule inhibitor,exerts curative antitumoral activity in vivo,shows eficacy toward muhidrug-resistant tumor cells,and lacks neurotoxicity显示文摘 | Bacher G Nickel B Emig P | 2001 | Cancer Res2001，61，1： | 1 |
| 6 | Predictors of patient response to antibiotic therapy for the chronic prostatitis/chronic pelvic pain syndrome : a prospective multicenter clinical trial 显示文摘 | Nickel JC Downey J Johnston B | 2001 | J Urol2001，165，5： | 1 |
| 7 | Human chorionic somatomammotropin and growth hormone gene expression in rat pituitary tumour cells is dependent on proximal promoter sequences 显示文摘 | Nachigal M W Nickel B E Klassen M E | 1989 | Nucl Acids Res1989，17，： | 1 |
| 8 | Real-time image guidance in laparoscopic liver surgery: first clinical experience with a guidance system based on intraoperative CT imaging显示文摘 | Hannes G. Kenngott Martin Wagner Matthias Gondan Felix Nickel Marco Nolden Andreas Fetzer Jürgen Weitz Lars Fischer Stefanie Speidel Hans-Peter Meinzer Dittmar B?ckler Markus W. Büchler Beat P. Müller-Stich | 2014 | Surgical Endoscopy2014，，3： | 1 |
| 9 | Effects of pre-treatment on the growth rate and morphology of hard anodic films on aluminium (EN AW-6082)显示文摘 | Wielage B Nickel D Alisch G | 2007 | Surface & Coatings Technology2007，202，： | 1 |
| 10 | Flashless precision forging of a two-cylinder-crankshaft 显示文摘 | BEHRENS B A NICKEL R MI~LLER S | 2009 | Production Engineering2009，3，45： | 1 |
| 11 | Chronic prostatitis/chronic pelvic pain syndrome and male interstitial cystitis:enigmas and opportunities显示文摘 | Forrest J B Nickel J C Moldwin R M | 2007 | Urology2007，69，4： | 1 |
| 12 | Predictors of patient response to antibiotic therapy for the chronic prostatitis/chronic pelvic pain syndrome: a pro- spective multicenter clinical trial显示文摘 | Nickel JC Downey J Johnston B | 2001 | J Urol2001，165，： | 1 |
| 13 | Message from the German muhicentre allergy study 显示文摘 | Nickel K Lau S Niggemann B | 2002 | Pediatr Allergy Immunol2002，17，15： | 1 |
| 14 | Introduction into the electron beam welding of austenitic 321-type stainless steel 显示文摘 | Yilbas B S Sami M Nickel J | 1998 | Journal of Materials Processing Technology1998，82，： | 1 |
| 15 | Identification of complement receptor type I-related proteins on primate eruthrocytes显示文摘 | SUBRAMANNIAN V B | 1995 | J Immunol1995，154，6： | 1 |
| 16 | Predictors of patient response to antibiotic therapy for the chronic prostatitis/chronic pelvic pain syndrome:a prospective multicenter clinical trial显示文摘 | Nickel J C Downey J Johnston B | 2001 | J Urol2001，165，： | 1 |
| 17 | Thermal stress and deposi- tion patterns in layered manufacturing 显示文摘 | Nickel A H Barnett D M Prinz F B | 2001 | Materials Science and Engineering A2001，317，12： | 1 |
| 18 | Analysis of the friction welding process in relation to the welding of copper and steel bars 显示文摘 | SAHIN A Z YIBAS B S AHMED M NICKEL J | 1998 | J Mater Process Teehnol1998，82，13： | 1 |
| 19 | Adaptive beamforming algorithms with robustness against jammer motion显示文摘 | Gershman A B Nickel U Bohme J F | 1997 | IEEE Transactions on Signal Processing1997，，45： | 1 |
| 20 | Occurrence of apple stem grooving capillovirus in Santa Catarina, Brazil, detected by RT-PCR 显示文摘 | NICKEL O JELKMANN W KUHN G B | 1999 | Fitopatologia Brasileira1999，24，3： | 1 |
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