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| 1 | Are there new approaches for diagnosis, therapy guidance and outcome prediction of sepsis?显示文摘Beside many efforts to improve outcome, sepsis is still one of the most frequent causes of death in critically ill patients. It is the most common condition with high mortality in intensive care units. The complexity of the septic syndrome comprises immunological aspects- i.e.,sepsis induced immunosuppression- but is not restricted to this fact in modern concepts. So far, exact mechanisms and variables determining outcome and mortality stay unclear. Since there is no typical risk profile, early diagnosis and risk stratification remain difficult, which hinders rapid and effective treatment initiation. Due to the heterogeneous nature of sepsis, potential therapy options should be adapted to the individual. Biomarkers like C-reactive protein and procalcitonin are routinely used as complementary tools in clinical decision-making. Beyond the acute phase proteins, a wide bunch of promising substances and non-laboratory tools with potential diagnostic and prognostic value is under intensive investigation. So far, clinical decision just based on biomarker assessment is not yet feasible. However, biomarkers should be considered as a complementary approach. | Dubravka Kojic Benedikt H Siegler Florian Uhle Christoph Lichtenstern Peter P Nawroth Markus A Weigand Stefan Hofer Thorsten Brenner | 2015 | World Journal of Experimental Medicine2015，5，2： | 14 |
| 2 | 内皮Notch信号的抑制阻碍脂肪酸转运并导致成年心脏的代谢和血管重塑显示文摘营养成分在被肌肉细胞代谢利用之前通过内皮细胞转运。然而,对于内皮运输过程的调节知之甚少。Notch信号传导是发育过程中代谢和血管生成的关键调控因子。在该研究中,Jabs等研究了成年小鼠内皮Notch信号的遗传和药理学调控如何影响内皮脂肪酸转运、心脏血管生成和心脏功能。 | 刘青 叶鹏 Jabs M Rose AJ Lehmann LH Taylor J Moll I Sijmonsma TP Herberich SE Sauer SW Poschet G Federico G Mogler C Weis EM Augustin HG Yan M Gretz N Schmid RM Adams RH Gr9ne HJ Hell R Okun JG Backs J Nawroth PP Herzig S Fischer A | 2018 | 中华高血压杂志2018，26，3： | 6 |
| 3 | Gastric Bypass Leads to Improvement of Diabetic Neuropathy Independent of Glucose Normalization—Results of a Prospective Cohort Study (DiaSurg 1 Study)显示文摘 | Beat P. Müller-Stich Lars Fischer Hannes G. Kenngott Matthias Gondan Jonas Senft Gabriella Clemens Felix Nickel Thomas Fleming Peter P. Nawroth Markus W. Büchler | 2013 | Annals of Surgery2013，，5： | 2 |
| 4 | The AGE/RAGE/NF-κB Pathway May Contribute to the Pathogenesis of Polyneuropathy in Impaired Glucose Tolerance (IGT)显示文摘 | K.-M. Haslbeck E. Schleicher A. Bierhaus P. Nawroth M. Haslbeck B. Neund?rfer D. Heuss | 2005 | Exp Clin Endocrinol Diabetes2005，，05： | 2 |
| 5 | ROLE OF TOLL-LIKE RECEPTORS 2 AND 4, AND THE RECEPTOR FOR ADVANCED GLYCATION END PRODUCTS IN HIGH-MOBILITY GROUP BOX 1-INDUCED INFLAMMATION IN VIVO显示文摘 | Marieke A.D. van Zoelen Huan Yang Sandrine Florquin Joost C.M. Meijers Shizuo Akira Bernd Arnold Peter P. Nawroth Angelika Bierhaus Kevin J. Tracey Tom van der Poll | 2009 | Shock2009，，3： | 2 |
| 6 | The open pulled straw vitrification of ovine GV -oocytes:Positive effect of rapid cooling or rapid thawing or both 显示文摘 | ISACHENKO V ALABART J L NAWROTH F | 2001 | Cryo Letters2001，22，： | 1 |
| 7 | Peritoneal macrophages mediated delivery of chitosan/ siRNA nanoparticle to the lesion site in a murine radiation-induced fibrosis model 显示文摘 | Nawroth I | 2013 | Acta Oncol2013，52，8： | 1 |
| 8 | Extracellular sulfatases, elements of the Wnt signaling pathway, positively regulate growth and tumorigenicity of human pancreatic can- cer cells显示文摘 | Nawroth R van Zante A Cervantes S | 2007 | PLoS One2007，2，4： | 1 |
| 9 | Peritoneal macrophages mediated delivery of chitosan/ siRNA nanoparticle to the lesion site in a murine radiation-induced fibrosis model显示文摘 | Nawroth I | 2013 | Acta Oncol2013，52，8： | 1 |
| 10 | Is there a need for recombinant human luteinizing Hormone (lutropin alfa) supplementation inovarian stimulation for assisted reproduction? 显示文摘 | Nawroth F Ludwig M | 2006 | Womens Health (Lond Engl)2006，2，3： | 1 |
| 11 | The role of oxidative stress in the onset and progression of diabetes and its complication:a summary of a Congress Series sponsored by UNESCOMCBN,the American Diabetes Association,and the German Society显示文摘 | Rosen P Nawroth PP King G | 2001 | Diabetes Metab Res Rev2001，17，： | 1 |
| 12 | Circulating Vascular Cell Adhesion Molecule-1 Correlates with the Extent of Human Atherosclerosis in Contrastto Circulating Intercellular Adhesion Molecule-I, E-selection, Pselectin, and Thrombomodulin 显示文摘 | Peter K Nawroth P Conradt C | 1997 | Arterioscler Thromb Vasc Biol1997，17，3： | 1 |
| 13 | Modulation of endothelial cell hemostatic properties by tumor necrosis factor显示文摘 | Nawroth P P Stem D M | 1986 | J Exp Med1986，163，： | 1 |
| 14 | The Open Fulled Straw Vitrification of Ovine GV-ooeytes: Positive Effect of Rapid Cooling or Rapid Cooling or Rapid Thawing or Both 显示文摘 | Isachenko V Alabart J L Nawroth F Isachenko E Va- jta G Floeh J | 2001 | Cryo Let- ters2001，22，3： | 1 |
| 15 | EMMPRIN regulates the canonical Wnt/beta-catenin signaling pathway,a potential role in accelerating lung tumorigenesis显示文摘 | Sidhu SS Nawroth R Retz M | 2010 | Oncogene2010，29，29： | 1 |
| 16 | Conservative treatment of ectopic pregnancy in a cesarean section scar with methotrexate:a case report显示文摘 | Nawroth F Foth D Wilhelm L | 2001 | Eur J Obstet Gynecol Reprod Biol2001，99，1： | 1 |
| 17 | Conservative treatment ot ectopic pregnancy in a cesarean section scar with methotrexate : a case report 显示文摘 | Nawroth F Foth D Willhelm L | 2001 | Eur J Obstet Gynecol Reprod Biol2001，99，1： | 1 |
| 18 | Poten- tial importance of vitrification in reproductive medicine 显示文摘 | Liebermann J Nawroth F Isachenko V | 2002 | BiolReprod2002，67，6： | 1 |
| 19 | Modulation of endothial cell hemostatic properties bytumor neorosis factor显示文摘 | Nawroth PP Ster n DM | 1986 | J Exp Med1986，163，3： | 1 |
| 20 | Conservative treatment of ectopic pregnancy in a cesarean section scar with methotrexate :a case re- port显示文摘 | Nawroth F Foth D Wilhelm L | 2001 | Eur J Obstet Gynecol Reprod Biol2001，99，1： | 1 |
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