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	题名	作者	年代	出处	被引量
1	Activity and bioavailability of tepotinib for leptomeningeal metastasis of NSCLC with MET exon 14 skipping mutation显示文摘Tepotinib is a key drug for cancer patients with mesenchymal-epithelial transition receptor tyrosine kinase proto-oncogene(MET)exon 14 skipping mutation.However,its bioavailability in the cerebrospinal fluid(CSF)in humans has not been fully elucidated.Moreover,information about the efficacy of tepotinib in patients with leptomeningeal metastasis is limited.Here,we present the case of a 56-year-old man who was diagnosed with lung adenocarcinoma with MET exon 14 skipping mutation.He was urgently hospitalized due to leptomeningeal metastasis.We administered tepotinib 500 mg/day as the second-line therapy and observed improvement in leptomeningeal metastasis and performance status.The tepotinib concentrations reached 1,648 ng/mL in the plasma and 30.6 ng/mL in the CSF,with a penetration rate(CSF/plasma)of 1.83%.These demonstrate tepotinib could achieve a high rate of central nervous system transition and could be effective against leptomeningeal metastasis.	Hisashi Tanaka Kageaki Taima Tomonori Makiguchi Junichi Nakagawa Takenori Niioka Sadatomo Tasaka	2021	Cancer Communications2021，41，1：	4
2	Absolute bioavailability and metabolism of omeprazole in relation to CYP2C19 genotypes following single intravenoos and oral administrations 显示文摘	Uno T Niioka T Hayakari M	2007	Eur J Clin Pharmacol2007，63，2：	1
3	Sensitive determination of omeprazole and its two main metabolites in human plasma by column-switching high-performance liquid chromatography: application to pharmacokinetic study in relation to CYP2C19 genotypes 显示文摘	SHIMIZU M UNO T NIIOKA T	2006	J Chromatogr B Analyt Technol Riomed Life Sci2006，832，2：	1
4	Gene expression of interstitial collagenase in both progressive and recovery phase of rat liver fibrosis induced by carbon tetrachloride 显示文摘	Watanabe T Niioka M Hozawa S	2000	J Hepatol2000，33，2：	1
5	Butyrate-producing pro- biotics reduce nonalcoholic fatty liver disease progression in rats: new insight into the probiotics for the gut-liver axis显示文摘	Endo H Niioka M Kobayashi N	2013	PLoS One2013，8，63：	1
6	Absolute bioavailability and metabolism of omeprazole in rela- tion to CYP2C19 genotypes following single intra- venous and oral administrations显示文摘	Uno T Niioka T Hayakari M	2007	Eur J Clin Pharmacol2007，63，2：	1
7	Flame stabilization characteristics of a strut divided into two parts in supersonic airflow显示文摘	Niioka T Terada K H Kobayashi S	1995	Journal of Propulsion and Power1995，11，1：	1
8	Dynamic change of cells expressing MMP-2 mRNA and MTl一MMP mRNA in the recovery from liver fibrosis in the rat显示文摘	WATANABE T NIIOKA M ISHIKAWA A et a1	2001	J Hepatol2001，35，：	1
9	Radiation extinction limit of counterflow premixed lean methane2air flames显示文摘	GUO H Y MARUTA K NIIOKA T		0，，：	1
10	The Effect of Radiation Reabsorption on NO For- mation in CH4/Air Counterflow Diffusion FI- ames 显示文摘	JINGFU WANG TAKASHI NIIOKA	2001	Theory and Modeling2001，15，3：	1
11	Different effects of the selective serotonin reuptake inhibitors fluvoxam- ine, paroxetine, and sertraline on the pharmacokinetics of fexo- fenadine in healthy volunteers显示文摘	Saruwatari J Yasui Furukori N Niioka T	2012	J Clin Psychopharmacol2012，32，2：	1
12	Reduced kinetic mechanism of ignitionfor nonpremixed hydrogen/air in a supersonic mixinglayer 显示文摘	JU Y NIIOKA T	1994	Combust Flame1994，99，2：	1
13	Gene expression of interstitial collagenase in both progressive and recovery phase of rat liver fibrosis induced by carbon tetrachloride显示文摘	Tetsu Watanabe Maki Niioka Shigenari Hozawa Kaori Kameyama Tatsuhiko Hayashi Masao Arai Akiko Ishikawa Katsuya Maruyama Isao Okazaki	2000	Journal of Hepatology2000，，2：	1
14	Gene expression of interstitial collagenase in both progressive and recovery phase of rat liver fibrosis induced by carbon tetrachloride显示文摘	Watanabe T Niioka M Hozawa S	2000	J Hepatol2000，33，：	1
15	Dynamic-change of cells expressin MMP-2 mRNA and MT1-MMP mRNA in the recovery from liver fibrosis in the rat显示文摘	WALANABE T NIIOKA M ISHIKAWA A	2001	J Hepatol2001，35，：	1
16	Dynamic change of cells expressing MMP - 2 mRNA and MTI - MMP mRNA in the recovery from liver fibrosis in the rat显示文摘	Watanabe T Niioka M Ishikawa A	2001	J Hepatol2001，35，4：	1
17	Gene expression of interstitial collagenase in both progressive and recovery phase of rat liver fibrosis induced by carbon tetrachloride显示文摘	Watanabe T Niioka M Hozawa S	2000	J Hepatol2000，33，2：	1
18	Effect of itraconazole on pharmacokinetics of paroxetine,the role of gut transporters显示文摘	Yasui-Furukori N Saito M Niioka T	2007	Ther Drug Monit2007，29，1：	1
19	Limited sampling strategy for simultaneous estimation of the area under the concentration-time curve of tacrolimus and mycophenolic acid in adult renal transplant recipients 显示文摘	Miura M Satoh S Niioka T	2008	Ther Drug Monit2008，30，：	1
20	Differences in mediator of nonadrenergic, noncholinergic relaxation of the distal colon between Wista-ST and Sprague-Dawley strains of rats显示文摘	Okishio Y Niioka S Takeuchi T Nishio H Hata F Takatsuji K	2000	Eur J Pharmacol2000，388，1：	1

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