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| 1 | Chronic myeloid leukemia-from the Philadelphia chromosome to specific target drugs:A literature review显示文摘Chronic myeloid leukemia(CML)is a myeloproliferative neoplasm and was the first neoplastic disease associated with a well-defined genotypic anomaly―the presence of the Philadelphia chromosome.The advances in cytogenetic and molecular assays are of great importance to the diagnosis,prognosis,treatment,and monitoring of CML.The discovery of the breakpoint cluster region(BCR)-Abelson murine leukemia(ABL)1 fusion oncogene has revolutionized the treatment of CML patients by allowing the development of targeted drugs that inhibit the tyrosine kinase activity of the BCR-ABL oncoprotein.Tyrosine kinase inhibitors(known as TKIs)are the standard therapy for CML and greatly increase the survival rates,despite adverse effects and the odds of residual disease after discontinuation of treatment.As therapeutic alternatives,the subsequent TKIs lead to faster and deeper molecular remissions;however,with the emergence of resistance to these drugs,immunotherapy appears as an alternative,which may have a cure potential in these patients.Against this background,this article aims at providing an overview on CML clinical management and a summary on the main targeted drugs available in that context. | Mariana Miranda Sampaio Maria Luísa Cordeiro Santos Hanna Santos Marques Vinícius Lima de Souza Gonçalves Glauber Rocha Lima Araújo Luana Weber Lopes Jonathan Santos Apolonio Camilo Santana Silva Luana Kauany de SáSantos Beatriz Rocha Cuzzuol Quézia Estéfani Silva Guimarães Mariana Novaes Santos Breno Bittencourt de Brito Filipe Antônio França da Silva Márcio Vasconcelos Oliveira Cláudio Lima Souza Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，2： | 3 |
| 2 | Prostate tumor OVerexpressed-1(PTOV1)down-regulates HES1 and HEY1 notch targets genes and promotes prostate cancer progression显示文摘 | Alaoa L SeséM Cánovas V | 2014 | Mol Cancer2014，13，： | 1 |
| 3 | Viscoelastic properties of reduced-fat and full-fat cheddar cheeses显示文摘 | MA L DRAKE M A BARBOSA-C /NOVAS G V | 1996 | Journal of Food Science1996，61，4： | 1 |
| 4 | Tea polyphenol epigallocatechin-3-gallate inhibits ergosterol synthesis by disturbing folic acid metabolism in Candida albicans显示文摘 | Navarro-Martínez M D García-Cánovas F Rodríguez-López J N | 2006 | Journal of Antimicrobial Chemotherapy2006，57，6： | 1 |
| 5 | The chemistry of the NO/NO2-NH3 'fast' SCR reaction over Fe-ZSM-5 investigated by transient reaction analysis 显示文摘 | GROSSALE A NOVA I TRONCONI E CHATTERJEE D WEIBEL M | 2008 | J Catal2008，256，2： | 1 |
| 6 | Effect of non-surgical periodontal therapy on glycemic control in patients with type 2 diabetes mellitus 显示文摘 | RODRIGUES D C TABA M J NOVAES A B | 2003 | J Periodontal2003，74，9： | 1 |
| 7 | A constitutive model for sand in triaxial compression 显示文摘 | Nova R Wood D M | 1979 | International Journal for Nu- merical and Analytical Methods in Geomechanics1979，，3： | 1 |
| 8 | Modeling ot soil structure mtertace behavior: A comparison between elastoplastic and ratetype laws 显示文摘 | Boulon M Nova R | 1990 | Computers and Geotechnics1990，17，9： | 1 |
| 9 | Advances in dehydration of foods 显示文摘 | VEGA-MERCADO H GO' NGORA-NIETO M M BARBOSA-CA'NOVAS G V | 2001 | Journal of Food Engineering2001，49，： | 1 |
| 10 | On modeling the unloading-reloading behavior of soils显示文摘 | ZYTYNSKI M RANDOLPH M F NOVA R | 1978 | International Journal for Numerical and Analytical Methods in Geomechanics1978，，2： | 1 |
| 11 | Ammonium assimilation and amino acid metabolism in conifers显示文摘 | Cánovas F M Avila C Cantón F R Caňas R A Torre F | 2007 | Journal of Experimental Botany2007，58，9： | 1 |
| 12 | Influence of Implant Microstructure on the Dynamics of Bone Healing Around Immediate Implants Placed into Periodontally Infected Sites显示文摘 | PAPALEXIOU V NOVAES A B GRISE M F M | 2004 | Clinical Oral Implants Research2004，15，1： | 1 |
| 13 | Modeling of soil structure interface behavior:A comparison between elasto plastic and rate type laws显示文摘 | Nova R | 1990 | Computers and Geotechnics1990，17，9： | 1 |
| 14 | Selective activation of the ortho C--F bond in pentafluoropyridine by zerovalent nickel: Reaction via a metallophosphorane intermediate stabilized by neighboring group assistance from the pyridyl nitrogen显示文摘 | Nova A Reinhold M Perutz R N | 2010 | Organometallics2010，29，： | 1 |
| 15 | Stressors inICU : perception of the patient,relatives and health-careteam显示文摘 | Novaes M A Knobel E Bork A M | 1999 | Int Care Med1999，25，12： | 1 |
| 16 | Association between ambient air pollution and birth weight in S? o Paulo, Brazil 显示文摘 | GOUVEIA N BREMNER S A NOVAES H M D | 2004 | J Epidemiol Community Health2004，58，： | 1 |
| 17 | Noise and vibration reduction for small/medium car market segment:an innovative approach for engineering design and manufacturing显示文摘 | NOVA M TAMBURRO A | 1997 | Automotive Vehicle Technologies1997，51，3： | 1 |
| 18 | Design, construction and testing of explosive-driven helical generators显示文摘 | Novae B M Smith I R Stewardson H R | 1995 | J Phys D : Appl Phys1995，28，： | 1 |
| 19 | A constitutive model for sand in triax- ial compression 显示文摘 | Nova R Wood D M | 1979 | International Journal for Numerical Analytical Methods in Geomechanics1979，3，3： | 1 |
| 20 | Elaboration, characterization and study of a new hybrid chitosan/ ceramic membrane for affinity membrane chromatography显示文摘 | NOVA C J M PAOLUCCI-JEANJEAN D BELLEVILLE M P | 2008 | Journal of Membrane Science2008，321，： | 1 |
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